Pin75 Estimation of Patients With Antiretroviral Therapy Potentially Used for Hiv Prevention (Post-Exposure Prophylaxis, Mother-to-Child Transmission Prophylaxis) in Germany

Tomeczkowski, Jörg; Guthoff-Hagen, S; Biteeva, I; Kruppert, Silvia; Stoll, Matthias

doi:10.1016/s1098-3015(11)72873-x

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“…Analysis of data from German health insurance companies potentially underestimates the cost impact of cART in PLWHA. Insurance databases include a significant proportion of single prescriptions of antiretroviral drugs, presumably for post-exposure prophylaxis [18] . This underlines the impact of treatment cohort data for the calculation of lump sums such as the Morbi-RSA in the future.…”

Section: Discussionmentioning

confidence: 99%

Calculation of Direct Antiretroviral Treatment Costs and Potential Cost Savings by Using Generics in the German HIV ClinSurv Cohort

et al. 2011

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Background/Aim of the StudyThe study aimed to determine the cost impacts of antiretroviral drugs by analysing a long-term follow-up of direct costs for combined antiretroviral therapy, cART,-regimens in the nationwide long-term observational multi-centre German HIV ClinSurv Cohort. The second aim was to develop potential cost saving strategies by modelling different treatment scenarios.MethodsAntiretroviral regimens (ART) from 10,190 HIV-infected patients from 11 participating ClinSurv study centres have been investigated since 1996. Biannual data cART,-initiation, cART-changes, surrogate markers, clinical events and the Centre of Disease Control- (CDC)-stage of HIV disease are reported. Treatment duration was calculated on a daily basis via the documented dates for the beginning and end of each antiretroviral drug treatment. Prices were calculated for each individual regimen based on actual office sales prices of the branded pharmaceuticals distributed by the license holder including German taxes.ResultsDuring the 13-year follow-up period, 21,387,427 treatment days were covered. Cumulative direct costs for antiretroviral drugs of €812,877,356 were determined according to an average of €42.08 per day (€7.52 to € 217.70). Since cART is widely used in Germany, the costs for an entire regimen increased by 13.5%. Regimens are more expensive in the advanced stages of HIV disease. The potential for cost savings was calculated using non-nucleotide-reverse-transcriptase-inhibitor, NNRTI, more frequently instead of ritonavir-boosted protease inhibitor, PI/r, in first line therapy. This calculation revealed cumulative savings of 10.9% to 19.8% of daily treatment costs (50% and 90% substitution of PI/r, respectively). Substituting certain branded drugs by generic drugs showed potential cost savings of between 1.6% and 31.8%.ConclusionsAnalysis of the data of this nationwide study reflects disease-specific health services research and will give insights into the cost impacts of antiretroviral therapy, and might allow a more rational allocation of resources within the German health care system.

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Section: Discussionmentioning

confidence: 99%