PINCH-1 promotes Δ1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma

Cui, Chunhong; Wang, Jiaxin; Guo, Ling; Wu, Chuanyue

doi:10.1007/s00726-021-03050-3

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Depletion of Kindlin 2 reduces PYCR1 levels, increases ROS production and abolishes ECM stiffening-induced increase of proline synthesis and cell proliferation. Pinch-1, a cell-extracellular adhesion protein, promotes proline biosynthesis by increasing the expression of P5CS (Cui et al 2021 ). Interestingly, SIRT3 regulates proline synthesis by deacetylation of PYCR1 enzyme protein and increasing proline synthesis (Chen et al 2019 ), and knockdown of PYCR1 in lung adenocarcinoma inhibits the proliferation and invasion by modulating JAK/STAT (Gao et al 2020 ).…”

Section: Proline Metabolism and Cancermentioning

confidence: 99%

Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis

Phang

2021

Amino Acids

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In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases. In addition, the multi-layered connections of the proline cycle and the role of proline and hydroxyproline in collagen provide an important regulatory link between the extracellular matrix and metabolism.

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Section: Proline Metabolism and Cancermentioning

confidence: 99%

Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis

Phang

2021

Amino Acids

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“…Proline synthesis is a classic metabolic axis that is closely related to mechanotransduction from the ECM. On stiffer ECM, kindlin2 enhances the structural stability and activity of PYCR1, thereby increasing PYCR1 levels and proline synthesis [102]. This mechanism explains the high level of PYCR1 in Aging and Disease • advanced lung adenocarcinomas characterized by a stiffer tumor stroma [102].…”

Section: Cytoskeleton and Mitochondrial Dynamicsmentioning

confidence: 99%

“…On stiffer ECM, kindlin2 enhances the structural stability and activity of PYCR1, thereby increasing PYCR1 levels and proline synthesis [ 102 ]. This mechanism explains the high level of PYCR1 in advanced lung adenocarcinomas characterized by a stiffer tumor stroma [ 102 ]. In addition, proline plays a significant role in collagen synthesis, which indicates a potential interrelationship between mitochondrial kindlin2 and collagen.…”

Section: Cytoskeletal System and Mitochondriamentioning

confidence: 99%

Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction

et al. 2023

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Cells are constantly exposed to various mechanical environments; therefore, it is important that they are able to sense and adapt to changes. It is known that the cytoskeleton plays a critical role in mediating and generating extra-and intracellular forces and that mitochondrial dynamics are crucial for maintaining energy homeostasis. Nevertheless, the mechanisms by which cells integrate mechanosensing, mechanotransduction, and metabolic reprogramming remain poorly understood. In this review, we first discuss the interaction between mitochondrial dynamics and cytoskeletal components, followed by the annotation of membranous organelles intimately related to mitochondrial dynamic events. Finally, we discuss the evidence supporting the participation of mitochondria in mechanotransduction and corresponding alterations in cellular energy conditions. Notable advances in bioenergetics and biomechanics suggest that the mechanotransduction system composed of mitochondria, the cytoskeletal system, and membranous organelles is regulated through mitochondrial dynamics, which may be a promising target for further investigation and precision therapies.

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Transcriptomic Analysis of Cardiac Tissues in a Rodent Model of Coronary Microembolization

Jiang,

Lu,

Gao

et al. 2024

JIR

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PINCH-1 promotes Δ1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma

Cited by 3 publications

References 41 publications

Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis

Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis

Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction

Transcriptomic Analysis of Cardiac Tissues in a Rodent Model of Coronary Microembolization

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