Pinch-off droplet generator using microscale gigahertz acoustics

Zhou, Yangchao; He, Meihang; Zhang, Haitao; Liu, Bohua; Sun, Chongling; Han, Ziyu; Duan, Xuexin

doi:10.1039/d3lc00515a

Cited by 6 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, acoustic waves induced by the piezoelectric effect have been employed to drive liquids and manipulate particles in a wide range of miniaturized systems (especially microfluidic systems) [ 57 – 67 ]. These piezoelectric chips fabricated via advanced microelectromechanical system techniques [ 68 , 69 ] enable acoustofluidic micropumps (AFMPs) with great portability (simple and small structures, low power consumption, and low working voltage), high biocompatibility, a fast response time, and fair extensibility [ 23 , 50 – 54 ], which theoretically meets the requirements of a portable system as an ideal micropump.…”

Section: Introductionmentioning

confidence: 99%

“…However, the existing AFMPs have unsatisfactory pumping performance due to their limited energy transduction efficiency (Table S2 ). Recently, gigahertz (GHz) bulk acoustic waves (BAWs) have been demonstrated to induce intense acoustic streaming in a very small area due to the focused acoustic wave and rapid dissipation at the device–liquid interface, which have been applied for different applications, including solution mixing, droplet dispensing, and bioparticle manipulation [ 59 , 62 , 66 , 67 , 70 , 71 ]. However, for pumping applications, the GHz acoustic streaming tends to be vortical in nature, which prevents the formation of unidirectional flow.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Miniaturized Wireless Micropump Enabled by Confined Acoustic Streaming

You,

Fan,

Wang

et al. 2024

Research

Self Cite

View full text Add to dashboard Cite

Miniaturization of health care, biomedical, and chemical systems is highly desirable for developing point-of-care testing (POCT) technologies. In system miniaturization, micropumps represent one of the major bottlenecks due to their undesirable pumping performance at such small sizes. Here, we developed a microelectromechanical system fabricated acoustic micropump based on an ultrahigh-frequency bulk acoustic wave resonator. The concept of an inner-boundary-confined acoustic jet was introduced to facilitate unidirectional flow. Benefitting from the high resonant frequency and confined acoustic streaming, the micropump reaches 32.620 kPa/cm 3 (pressure/size) and 11.800 ml/min∙cm 3 (flow rate/size), showing a 2-order-of-magnitude improvement in the energy transduction efficiency compared with the existing acoustic micropumps. As a proof of concept, the micropump was constructed as a wearable and wirelessly powered integrated drug delivery system with a size of only 9×9×9 mm 3 and a weight of 1.16 g. It was demonstrated for ocular disease treatment through animal experimentation and a human pilot test. With superior pumping performance, miniaturized pump size, ultralow power consumption, and complementary metal–oxide–semiconductor compatibility, we expect it to be readily applied to various POCT applications including clinical diagnosis, prognosis, and drug delivery systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Miniaturized Wireless Micropump Enabled by Confined Acoustic Streaming

You,

Fan,

Wang

et al. 2024

Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…BAWs have a lower energy density compared with SAWs, and researchers used high-frequency BAWs (MHz – GHz) to realize various functions, like mixing and droplet generation. 10–12 However, the low-frequency (kHz) BAWs' effect in a plain microchannel or a microchamber without special structures is usually neglected. Generally, micro solids like sharp edges or microbubbles are involved in micro space to obtain a strong response to low-frequency BAWs.…”

Section: Introductionmentioning

confidence: 99%

Acoustophoresis-driven particle focusing and separation with standard/inverse Chladni patterns

Zhao,

Hao

2024

Lab Chip

View full text Add to dashboard Cite

show abstract

A Miniaturized Device for Ultrafast On‐Demand Drug Release Based on a Gigahertz Ultrasonic Resonator

Zhou,

Jeong,

Zhang

et al. 2024

Adv Eng Mater

Self Cite

View full text Add to dashboard Cite

On‐demand controlled drug delivery is essential for the treatment of a wide range of chronic diseases. As the drug is released at the time when required, its efficacy is boosted and the side effects are minimized. However, so far, drug delivery devices often rely on the passive diffusion process for a sustained release, which is slow and uncontrollable. Herein, a miniaturized microfluidic device for wirelessly controlled ultrafast active drug delivery is presented, driven by an oscillating solid–liquid interface. The oscillation generates acoustic streaming in the drug reservoir, which opens an elastic valve to deliver the drug. High‐speed microscopy reveals the fast response of the valve on the order of 1 ms, which is more than three orders of magnitude faster than the start‐of‐the‐art. The amount of the released drug exhibits a linear relationship with the working time and the electric power applied to the ultrasonic resonator. The trigger of the release is wirelessly controlled via a magnetic field, and the system shows stable output in a continuous experiment for two weeks. The integrated system shows great promise as a long‐term controlled drug delivery implant for chronic diseases.

show abstract

Pinch-off droplet generator using microscale gigahertz acoustics

Abstract: The generation and dispensation of microdroplets is a vital process in various fields such as biomedicine, medical diagnosis and chemistry. However, most methods still require the structures of nozzles or...

Cited by 6 publications

References 47 publications

A Miniaturized Wireless Micropump Enabled by Confined Acoustic Streaming

A Miniaturized Wireless Micropump Enabled by Confined Acoustic Streaming

Acoustophoresis-driven particle focusing and separation with standard/inverse Chladni patterns

A Miniaturized Device for Ultrafast On‐Demand Drug Release Based on a Gigahertz Ultrasonic Resonator

Contact Info

Product

Resources

About