Pineal indols and testosterone affect exploratory activity of male rats

Rodrı́guez, Manuel; Sosa, Jennifer; Hernández, Guadalberto; Mas, Manuel

doi:10.1007/bf01952573

Cited by 17 publications

(4 citation statements)

References 17 publications

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“…One study showed that T administration to male rats did not affect open field activity (Bitran et al, 1993), whereas other studies showed that T concentrations were inversely related to activity in the open field, with higher T levels associated with less activity (Lambadjieva, 1998;Rodriguez, Sosa, Hernandez, & Mas, 1984). The rats in the present study received a sustained amount of T from the implants, which produced supraphysiological concentrations of androgens and may have been sufficient to produce modest changes in motor behavior.…”

Section: Discussionmentioning

confidence: 52%

Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats

Frye

Seliga

2001

Cognitive, Affective, & Behavioral Neuroscience

210

128

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Section: Discussionmentioning

confidence: 52%

Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats

Frye

Seliga

2001

Cognitive, Affective, & Behavioral Neuroscience

210

128

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“…Melatonin, a pineal secretory product, reportedly plays a role in the modulation of arterial blood pressure [1–4], locomotion [5, 6], and body temperature [7, 8]. For example, systemic administration of melatonin induces arterial hypotension, hypo‐locomotion and hypothermia in animals.…”

Section: Introductionmentioning

confidence: 99%

Melatonin potentiates 5‐HT_1A receptor activation in rat hypothalamus and results in hypothermia

Lin

Chuang

2002

Journal of Pineal Research

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Therapeutic hypothermia is widely applied as a neuroprotective measure on intracerebral hemorrhage (ICH). However, several clinical trials regarding physical hypothermia encountered successive failures because of its side-effects in recent years. Increasing evidences indicate that chemical hypothermia that targets hypothalamic 5-HT1a has potential to down-regulate temperature set point without major side-effects. Thus, this study examined the efficacy and safety of 5-HT1a stimulation in PO/AH area for treating ICH rats. First, the relationship between head temperature and clinical outcomes was investigated in ICH patients and rat models, respectively. Second, the expression and distribution of 5-HT1a receptor in PO/AH area was explored by using whole-cell patch and confocal microscopy. In the meantime, the whole-cell patch was subsequently applied to investigate the involvement of 5-HT1a receptors in temperature regulation. Third, we compared the efficacy between traditional PH and 5-HT1a activation-induced hypothermia for ICH rats. Our data showed that more severe perihematomal edema (PHE) and neurological deficits was associated with increased head temperature following ICH. 5-HT1a receptor was located on warm-sensitive neurons in PO/AH area and 8-OH-DPAT (5-HT1a receptor agonist) significantly enhanced the firing rate of warm-sensitive neurons. 8-OH-DPAT treatment provided a steadier reduction in brain temperature without a withdrawal rebound, which also exhibited a superior neuroprotective effect on ICH-induced neurological dysfunction, white matter injury and BBB damage compared with physical hypothermia. These findings suggest that chemical hypothermia targeting 5-HT1a receptor in PO/AH area could act as a novel therapeutic manner against ICH, which may provide a breakthrough for therapeutic hypothermia.

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“…Melatonin, which is synthesized in the pineal gland, may play an important role in modulation of locomotor activity [Data and King, 1980;Rodriguez et a]., 19841. Systemic or intracerebral administration of melatonin to animals decreased spontaneous locomotor activity [Kovacs et al, 1974;Golus and King, 1981;Sugden 1983; Gaffori and Van Ree, 19851.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological effects of melatonin treatment on both locomotor activity and brain serotonin release in rats

Chuang

Lin

1994

Journal of Pineal Research

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The effects of intraperitoneal administration of pharmacological doses of melatonin (60 mg/kg) on both locomotor activity and brain monoamine release were assessed in rats. The spontaneous levels of either horizontal motion, vertical motion, or total distance traveled were decreased following melatonin injection. On the other hand, the spontaneous levels of postural freezing increased after treatment. External heat exposure (36 degrees C) produced increases in locomotion (including horizontal motion, vertical motion, and total distance traveled) as well as decreases of postural freezing in rats. The heat-induced increases of horizontal motion and total distance traveled as well as decreases of postural freezing were attenuated by melatonin treatment. In addition, cold exposure (4 degrees C) produced increases of vertical motion as well as decreases of postural freezing. Again, the cold-induced behavioral responses were attenuated by melatonin treatment. Biochemical data revealed that the serum levels of melatonin were decreased by both heat and cold exposure in rats. Furthermore, voltammetric data revealed that intraperitoneal administration of melatonin (60 mg/kg) decreased serotonin, but not the dopamine, release in the hypothalamus, the corpus striatum or nucleus accumbens of rat brain. Neither the locomotor activity responses to thermal stress nor brain monoamine release was affected by a smaller dose of melatonin (30 mg/kg, i.p.). The results suggest that systemic administration of melatonin, at pharmacological doses, inhibits brain serotonin release and results in a reduction in both the spontaneous locomotion and the thermal stress-induced locomotor activity responses in rats.

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Pineal indols and testosterone affect exploratory activity of male rats

Cited by 17 publications

References 17 publications

Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats

Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats

Melatonin potentiates 5‐HT_1A receptor activation in rat hypothalamus and results in hypothermia

Pharmacological effects of melatonin treatment on both locomotor activity and brain serotonin release in rats

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Pineal indols and testosterone affect exploratory activity of male rats

Cited by 17 publications

References 17 publications

Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats

Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats

Melatonin potentiates 5‐HT1A receptor activation in rat hypothalamus and results in hypothermia

Pharmacological effects of melatonin treatment on both locomotor activity and brain serotonin release in rats

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Product

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Melatonin potentiates 5‐HT_1A receptor activation in rat hypothalamus and results in hypothermia