Pineal volume reduction as the neural correlate of very late-onset schizophrenia-like psychosis

Matsuoka, Teruyuki; Imai, Ayu; Narumoto, Jin

doi:10.1016/j.ajp.2022.103251

Cited by 1 publication

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“…A previous study reported apathy, hallucinations, and sleep disturbance to be more common in prodromal DLB than in prodromal AD, whereas no predominant NPSs were observed in prodromal AD. 30 Very late-onset schizophrenia-like psychosis might be a common symptom in prodromal AD 39 and prodromal DLB. 40,41 Therefore, similarities and differences in the NPSs could exist between preclinical/prodromal AD and prodromal PDD/DLB.…”

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confidence: 99%

Contribution of amyloid and putative Lewy body pathologies in neuropsychiatric symptoms

Matsuoka,

Narumoto,

Morii‐Kitani

et al. 2023

Int J Geriat Psychiatry

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ObjectivesNeuropsychiatric symptom could be useful for detecting patients with prodromal dementia. Similarities and differences in the NPSs between preclinical/prodromal Alzheimer's disease (AD) and prodromal Parkinson's disease dementia (PDD)/Dementia with Lewy bodies (DLB) may exist. This study aimed to compare the NPSs between preclinical/prodromal AD and prodromal PDD/DLB.MethodsOne hundred and three participants without dementia aged ≥50 years were included in this study. The mild behavioral impairment (MBI) total score and the MBI scores for each domain were calculated using the neuropsychiatric inventory questionnaire score. Participants were divided into five groups based on the clinical diagnosis by neurologists or psychiatrists in each institution based on the results of the amyloid positron emission tomography and dopamine transporter single photon emission computed tomography (DAT‐SPECT): Group 1: amyloid‐positive and abnormal DAT‐SPECT, Group 2: amyloid‐negative and abnormal DAT‐SPECT, Group 3: amyloid‐positive and normal DAT‐SPECT, Group 4: mild cognitive impairment unlikely due to AD with normal DAT‐SPECT, and Group 5: cognitively normal with amyloid‐negative and normal DAT‐SPECT.ResultsThe MBI abnormal perception or thought content scores were significantly higher in Group 1 than Group 5 (Bonferroni‐corrected p = 0.012). The MBI total score (Bonferroni‐corrected p = 0.011) and MBI impulse dyscontrol score (Bonferroni‐corrected p = 0.033) in Group 4 were significantly higher than those in Group 5.ConclusionThe presence of both amyloid and putative Lewy body pathologies may be associated with psychotic symptoms.

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