Pink Noise of Ionic Conductance through Single Artificial Nanopores Revisited

Tasserit, Christophe; Koutsioubas, Alexandros; Lairez, D.; Zalczer, G.; Clochard, Marie-Claude

doi:10.1103/physrevlett.105.260602

Cited by 74 publications

(80 citation statements)

References 39 publications

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“…Doing so, conical nanopores are obtained with a narrow size distribution, large opening radius B ≃ 200 nm (measured by scanning electron microscopy see Fig. 2) and small opening radius b ≃ 2 nm (estimated from the relation between this size, the conductivity of the electrolyte, and the measured conductance26). …”

Section: Methodsmentioning

confidence: 98%

The concept of entropic rectifier facing experiments

Lairez

Clochard

Wegrowe

2016

Sci Rep

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The transport of molecules in confined media is subject to entropic barriers. So theoretically, asymmetry of the confinement length may lead to molecular ratchets with entropy as the only driving force for the biased transport. We address experimentally this question by performing alternative ionic current measurements on electrolytes confined in neutral conical nanopores. In case anions and cations widely differ in size, we show that rectification of ionic current can be obtained that depends on ions size and cycle frequency, consistently with the entropic ratchet mechanism.

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Section: Methodsmentioning

confidence: 98%

The concept of entropic rectifier facing experiments

Lairez

Clochard

Wegrowe

2016

Sci Rep

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“…36). Self-organization of certain ionic liquids can be further exploited to reduce 1/f noise in single nanopores, as shown by Tasserit and co-authors 37 . Figure 3 presents the translocation traces of short DNA homopolymers for periods of 0.5 and 0.1 s, respectively.…”

Section: Differentiation Of 30-mer Dna Homopolymermentioning

confidence: 99%

Identification of single nucleotides in MoS2 nanopores

et al. 2015

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The size of the sensing region in solid-state nanopores is determined by the size of the pore and the thickness of the pore membrane, so ultrathin membranes such as graphene and single-layer molybdenum disulphide could potentially offer the necessary spatial resolution for nanopore DNA sequencing. However, the fast translocation speeds (3,000-50,000 nt ms -1 ) of DNA molecules moving across such membranes limit their usability. Here, we show that a viscosity gradient system based on room-temperature ionic liquids can be used to control the dynamics of DNA translocation through MoS 2 nanopores. The approach can be used to statistically detect all four types of nucleotide, which are identified according to current signatures recorded during their transient residence in the narrow orifice of the atomically thin MoS 2 nanopore. Our technique, which exploits the high viscosity of room-temperature ionic liquids, provides optimal single nucleotide translocation speeds for DNA sequencing, while maintaining a signal-to-noise ratio higher than 10. Single nucleotide identification 1,2 and DNA sequencing 3 have already been demonstrated with biological nanopores. However, the fragility of such pores, together with difficulties related to measuring their pA-range ionic currents and their dependence on biochemical reagents, means that solid-state nanopores remain an attractive alternative 4 . In contrast to biological pores, solid-state nanopores can operate in various liquid media and pH conditions, their production is scalable and compatible with nanofabrication techniques 5 , and they do not require the excessive use of biochemical reagents. These advantages are expected to make solid-state nanopore sequencing cheaper than sequencing with biological pores.The basic sensing principle in sold-state nanopores is the same as in biological pores. A DNA molecule is threaded through a nanometre-sized pore under an applied potential and, ideally, the sequence of nucleotides is read by monitoring small changes in the ionic current flowing through the pore that are caused by individual nucleotides temporarily residing within the pore 6 . However, solid-state nanopores also allow a transverse detection scheme, which is based on detecting changes in the electrical conductivity of a thin semiconducting channel 4 . In both biological and solid-state nanopores, achieving an optimal translocation speed remains a significant challenge , ref. 8) and are also limited by their use of enzymes. Therefore, to achieve genome sequencing, thousands-or even millons-of biological pores need to be integrated into one sequencer. In solid-state nanopores, translocation speeds are on the order of 3,000-50,000 nt ms , the large range being a result of factors such as the pore size (1.5-25 nm) and the applied potential (100-800 mV) 9 . These fast speeds limit the ability of solid-state nanopores to reach single-nucleotide resolution, and are a major obstacle to the use of solid-state nanopores in the sequencing of DNA.Solid-state nanopores also face proble...

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“…17 These results are in contrast to the recently reported system of single conically shaped nanopores in polymer films which rectified current and exhibited non-equilibrium 1/f noise: the normalized noise magnitude at 1 Hz, S(1Hz)/<I> 2 , increased with voltage in an exponential manner. 18,19,20 Polymer nanopores also showed a counter-intuitive result:…”

Section: Introductionmentioning

confidence: 99%

Noise Properties of Rectifying Nanopores

Powell

Davenport

et al. 2011

J. Phys. Chem. C

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Ion currents through three types of rectifying nanoporous structures are studied and compared for the first time: conically shaped polymer nanopores, glass nanopipettes, and silicon nitride nanopores. Time signals of ion currents are analyzed by power spectrum. We focus on the low-frequency range where the power spectrum magnitude scales with frequency, f, as 1/f. Glass nanopipettes and polymer nanopores exhibit non-equilibrium 1/f noise, thus the normalized power spectrum depends on the voltage polarity and magnitude. In contrast, 1/f noise in rectifying silicon nitride nanopores is of equilibrium character. Various mechanisms underlying the voltagedependent 1/f noise are explored and discussed, including intrinsic pore wall dynamics, and formation of vortices and non-linear flow patterns in the pore. Experimental data are supported by modeling of ion currents based on the coupled Poisson-Nernst-Planck and Navier Stokes equations. We conclude that the voltage-dependent 1/f noise observed in polymer and glass asymmetric nanopores might result from high and asymmetric electric fields inducing secondary effects in the pore such as enhanced water dissociation.2

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Pink Noise of Ionic Conductance through Single Artificial Nanopores Revisited

Cited by 74 publications

References 39 publications

The concept of entropic rectifier facing experiments

The concept of entropic rectifier facing experiments

Identification of single nucleotides in MoS2 nanopores

Noise Properties of Rectifying Nanopores

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