Pink1/Parkin deficiency alters circulating lymphocyte populations and increases platelet-T cell aggregates in rats
Jane E. Manganaro,
Katy Emanuel,
Benjamin G. Lamberty
et al.
Abstract:Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder and results from the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Pink1 and Parkin are proteins that function together in mitochondrial quality control, and when they carry loss-of-function mutations lead to familial forms of PD. While much research has focused on central nervous system alterations in PD, peripheral contributions to PD pathogenesis are increasingly appreciated. We report… Show more
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