2019
DOI: 10.1007/s12031-019-01385-x
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PINK1 Silencing Modifies Dendritic Spine Dynamics of Mouse Hippocampal Neurons

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Cited by 18 publications
(22 citation statements)
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“…In the present study, we observed that PINK1 expression induces changes in the dendrite density of C4da sensory neurons, suggesting that PINK1 modulates the dynamic plasticity of sensory neurons. Recent studies have also shown that PINK1 regulates dendrite morphogenesis and neuronal plasticity [41,42]. Thus, the results from our group and others suggest that PINK1 is an important regulator of dendrite plasticity.…”
Section: Discussionsupporting
confidence: 73%
“…In the present study, we observed that PINK1 expression induces changes in the dendrite density of C4da sensory neurons, suggesting that PINK1 modulates the dynamic plasticity of sensory neurons. Recent studies have also shown that PINK1 regulates dendrite morphogenesis and neuronal plasticity [41,42]. Thus, the results from our group and others suggest that PINK1 is an important regulator of dendrite plasticity.…”
Section: Discussionsupporting
confidence: 73%
“…Like primary neurons expressing mutant LRRK2 , Pink1 knockout mice exhibit reduced dendritic arbors in midbrain, cortical and hippocampal neurons [ 81 , 105 , 106 ]. Older, but not young (6-month vs 2-month) Pink1 knockout mice exhibit increased excitatory neurotransmission, accompanied by increased neurotransmitter release on KCl stimulation without changes in protein expression of synaptic vesicle proteins syntaxin1a, Munc-18 or SNAP25 [ 107 ].…”
Section: Mitochondrial Calcium Dysregulation In Neurodegenerative Diseasesmentioning
confidence: 99%
“…Interestingly, the authors found changes in actin regulatory proteins RhoGAP29 and ROCK2 which were concurrent with changes in spine morphology. The changes in dendritic spines, showing increased thin density spines and reduced head size of stubby spines, may be a sign of presymptomatic changes that lead to neurodegeneration in PD [ 149 ]. In comparison, a Pink1 KO rat model showed nigral neurodegeneration with 50% dopaminergic cell loss, an increase in striatal dopamine and serotonin content and significant motor deficits [ 136 ].…”
Section: Pink1/parkin In Neurodegenerationmentioning
confidence: 99%