2020
DOI: 10.1186/s10020-020-00179-x
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Pinocembrin mitigates depressive-like behaviors induced by chronic unpredictable mild stress through ameliorating neuroinflammation and apoptosis

Abstract: Background The majority of patients with chronic fatigue have a risk of comorbidity with depression. Pinocembrin (PB) is a kind of flavonoid molecule isolated from honey and propolis and has antimicrobial, anti-inflammatory, antioxidant, and anticancer function. The purpose of the current study was to determine the possible function of PB on treatment of depression. Methods A chronic unpredictable mild stress (CUMS) mouse model was established to m… Show more

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Cited by 40 publications
(31 citation statements)
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“…The levels of ROS in the hippocampus were measured by DCFDA, as previously described, with minor modifications. 20 Brain slides were incubated with DCFDA (20 μM) and dissolved with 0.1mol/L phosphate buffer solution (PBS, pH7.2) at 37 °C for 30 minutes in a dark environment. Fluorescent imaging was performed with a fluorescence microscope.…”
Section: Measurement Of Rosmentioning
confidence: 99%
“…The levels of ROS in the hippocampus were measured by DCFDA, as previously described, with minor modifications. 20 Brain slides were incubated with DCFDA (20 μM) and dissolved with 0.1mol/L phosphate buffer solution (PBS, pH7.2) at 37 °C for 30 minutes in a dark environment. Fluorescent imaging was performed with a fluorescence microscope.…”
Section: Measurement Of Rosmentioning
confidence: 99%
“…Also, pinocembrin inhibited cell apoptosis and regulated inflammatory factors expression such as interlukin-10, transforming growth factor-β in the hippocampus of CUMS animals. Moreover, CUMS inhibited the Nrf2/HO-1 signaling pathway and activated the phosphorylation of NF-κB which were converted by pinocembrin (Wang et al, 2020). Therefore, the antidepressant-like effect of honey administration in the current study might be due to the regulation of above mentioned neurochemical factors.…”
Section: Discussionmentioning
confidence: 61%
“…Flavanone pinocembrin ( 10 ) ( Figure 4 ) has many similarities with the aforementioned compounds; for a review, see [ 56 , 57 , 58 ]. It increases the levels of superoxide dismutase (SOD) and glutathione, but decreases the levels malondialdehyde (MDA), myeloperoxidase (MPO) and ROS, nitric oxide, neuronal nitric oxide synthase (nNOS) as well as inducible NOS (iNOS) [ 59 , 60 ]. It downregulates PI3K/AKT, and NF-κB signaling pathways [ 61 ], ERK1/2 and Rho-associated protein kinase (ROCK) signaling pathways and Ca 2+ concentration, and protects the mitochondria through ERK1/2-Nrf2 axis [ 62 ].…”
Section: Propolis Types Key Molecules and Their Biological Activitiesmentioning
confidence: 99%