Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism

Yao, Liyuan; Chen, Rui; He, Jiacai; Lin, Tingting; Qiu, Silin; Chen, Guohua; Chen, Hongfeng; Qiu, Shaofu

doi:10.1016/j.antiviral.2023.105570

Cited by 12 publications

(8 citation statements)

References 41 publications

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“…Several studies indicate that inflammatory response as well as immunity are modulated by AhR, emphasizing its involvement in the host response to alpha and beta-CoVs as well as to no-CoVs (Zika and Dengue). For example, the pharmacological block of AhR by chemicals (CH223191, FICZ) as well as by natural products (fungal SMs, bioflavonoids) that causes anti-CoVs activity in vitro , proves the relevance of AhR in CoVs infection, as well as indicates AhR as a druggable target for introducing new antivirals [ 14 , 17 , 22 , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] ]. Hypothetically, due to the chemical structure of 6 PP ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

Cerracchio,

Del Sorbo,

Serra

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

Cerracchio,

Del Sorbo,

Serra

et al. 2024

Heliyon

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“…Inhibition of the AhR has been found to reduce the proliferation of both HCoV-229E (human Corona Virus 229E, a type of Corona Virus that is less pathogenic and usually causes respiratory symptoms) and SARS-CoV-2, suggesting that AhR activation serves as a mechanism for coronaviruses to evade the immune response and promote viral replication (3). The bioflavonoid dihydroxyflavone pinostrobin (PSB) functions as a negative modulator in the AhR/CYP1A1 signaling pathway by influencing the catabolic pathways of linoleic and arachidonic acid, thereby exhibiting antiviral effects (19). It has been observed that various coronaviruses can activate AhR signaling in hosts, leading to an increase in the expression of AhR-pathway genes in patients infected with SARS-CoV-122 (4).…”

Section: Ahr and Coronavirus Infectionsmentioning

confidence: 99%

Role of aryl hydrocarbon receptors in infection and inflammation

Xu,

Lin,

Xie

et al. 2024

Front. Immunol.

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The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various ligands, including pollutants, microorganisms, and metabolic substances. It is expressed extensively in pulmonary and intestinal epithelial cells, where it contributes to barrier defense. The expression of AhR is pivotal in regulating the inflammatory response to microorganisms. However, dysregulated AhR expression can result in endocrine disorders, leading to immunotoxicity and potentially promoting the development of carcinoma. This review focuses on the crucial role of the AhR in facilitating and limiting the proliferation of pathogens, specifically in relation to the host cell type and the species of etiological agents involved in microbial pathogen infections. The activation of AhR is enhanced through the IDO1-AhR-IDO1 positive feedback loop, which is manipulated by viruses. AhR primarily promotes the infection of SARS-CoV-2 by inducing the expression of angiotensin-converting enzyme 2 (ACE2) and the secretion of pro-inflammatory cytokines. AhR also plays a significant role in regulating various types of T-cells, including CD4+ T cells and CD8+ T cells, in the context of pulmonary infections. The AhR pathway plays a crucial role in regulating immune responses within the respiratory and intestinal barriers when they are invaded by viruses, bacteria, parasites, and fungi. Additionally, we propose that targeting the agonist and antagonist of AhR signaling pathways could serve as a promising therapeutic approach for combating pathogen infections, especially in light of the growing prevalence of drug resistance to multiple antibiotics.

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“…14 Pinostrobin inhibits the proliferation of HCoV-OC 43 in human ileocecal colorectal adenocarcinoma cells by inhibiting the AHR/CYP1A1 pathway and increasing prostaglandin E2 (PGE2) levels. 21…”

Section: Antiviral Effectsmentioning

confidence: 99%

“…Pinostrobin alters lipid metabolomics, especially folate and arachidonic acid metabolism, in HRT-18 cells. 21 It reduces triglyceride (TG) levels in C3H10T1/2 mouse embryonic mesenchymal stem cells and inhibits adipogenic differentiation. Peroxisome proliferator-activated receptor-γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) are the most important transcription factors associated with adipogenesis and play a decisive role in adipogenic differentiation.…”

Section: Effects On Lipid Metabolismmentioning

confidence: 99%

Research Progress on the Pharmacological Effects and Molecular Mechanisms of Pinostrobin

Wang,

Zhao,

Chen

et al. 2023

Natural Product Communications

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Pinostrobin (5-hydroxy-7-methoxyflavanone) is an active flavonoid substance. It is widely present in many traditional Chinese herbs, including Carya cathayensis leaves, Boesenbergia rotunda and propolis. Pinostrobin possesses many pharmacological activities without significant toxicity. In addition to anti-inflammatory and antioxidant effects, pinostrobin also exerts antitumor effects. Pinostrobin is able to protect against infection by several viruses, bacteria, fungi, and parasites. Pinostrobin reduces the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), which is a promising target of lipid-lowering drugs. It also reduces high uric acid levels while not affecting the normal uric acid levels. Furthermore, it has protective effects on the liver, kidney, bone, skin, reproductive system, stomach and nerves. Due to its multifunctional effects and safety, pinostrobin has advantages for development as a novel drug for clinical application. Based on this, this current article summarized the research progress on the pharmacological effects and mechanisms of pinostrobin, to provide a reference for further development.

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Pinostrobin from plants and propolis against human coronavirus HCoV-OC43 by modulating host AHR/CYP1A1 pathway and lipid metabolism

Cited by 12 publications

References 41 publications

Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

Role of aryl hydrocarbon receptors in infection and inflammation

Research Progress on the Pharmacological Effects and Molecular Mechanisms of Pinostrobin

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