Pinpoint papular variant of polymorphous light eruption: clinical and pathological correlation

Bansal, Itisha; Kerr, Holly; Janiga, JJ; Qureshi, HS; Chaffins, Marsha; Lim, Hyun Sook; Ormsby, Adrian H.

doi:10.1111/j.1468-3083.2006.01482.x

Cited by 31 publications

(16 citation statements)

References 6 publications

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“…Overlying epidermal atrophy, exocytosis and a superficial perivascular lymphocytic infiltrate was also observed. These cases resembled the histo-pathology of pin point variant of PMLE described by Bansal [27].…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

A Clinico-Pathological Study of Poly Morphous Light Eruption

Pullabatla¹,

Kaliyaperumal²,

Sidhu³

2012

JCDSA

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The prevalence of PMLE varies from 5% to 15% in various studies across the world. PMLE is noticed in the first three decades of life. The mean age in females is 33 years whereas in males it is 35 years. Females are more often affected than males. PMLE appears to be an immunologically mediated response possibly a delayed hypersensitivity phenomenon to a photo antigen induced or up regulated in the skin after sun exposure. One hundred new PMLE cases were included in a two year period from 2006-2008. All patients, who had been on treatment and with concomitant dermatoses were excluded. On histo-pathological examination 68% showed diagnostic features, 20% showed grade-II features and 12% grade-III features. Histo-pathological grading also varied with the duration of the disease. Early lesions showed only grade-II and III picture whereas the diagnostic picture was evident with the longer duration of the disease. In the plaque type, 14 cases showed characteristic histology after three to four months. In conclusion, PMLE is commonly observed in females between 21 -30 years of age. Pruritus is the chief complaint and the time required for the development of rash increases with time of sun exposure. Most common morphological type is papule on the forearm. Papules and plaque type of lesions of PMLE of longer duration clinched the histo-pathological diagnosis.

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Section: Discussionmentioning

confidence: 95%

“…Several authors have speculated that PMLE is inherited as an autosomal dominant gene with reduced penetrance [27] but recent studies have shown a polygenic inheritance [13,14]. We recorded family history in 4% of patients.…”

Section: Discussionmentioning

confidence: 99%

A Clinico-Pathological Study of Poly Morphous Light Eruption

Pullabatla¹,

Kaliyaperumal²,

Sidhu³

2012

JCDSA

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“…For example, photoallergy often demonstrates spongiosis, an inflammatory intercellular edema of the epidermis. Phototoxicity may demonstrate spongiosis and epidermal keratinocyte necrosis (Bansal et al, 2006;Bolognia et al, 2007), whereas spongiosis and atypical mononuclear cells in the dermis and epidermis are suggestive of the reticuloid variant of chronic actinic dermatitis (Yashar and Lim, 2003). Finally, cutaneous porphyrias have dermatopathology features such as cell-poor subepidermal blisters and immunoglobulins and complement at the dermoepidermal junction and perivascular areas (Yashar and Lim, 2003).…”

Section: Histologymentioning

confidence: 96%

Photocontact Dermatitis

Langner

Maibach

Maier

2010

Hayes' Handbook of Pesticide Toxicology

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“…[4,5] A pinpoint papular variant of polymorphous light eruption in African Americans, in Singaporean patients of Asian origin and a micropapular light eruption in Japanese patients have also been described and appear to represent the same entity. [6][7][8][9][10] These reports have included small numbers of patients and biopsies, ranging from 1 to 25. We describe the clinicopathological features of the condition in 72 Indian patients seen in our hospital.…”

Section: Introductionmentioning

confidence: 99%