Pioglitazone, an activator of PPAR-gamma, reduces the expression of kB nuclear factor and inhibits apoptosis in mononuclear cells of peripheral blood in vitro

Kutsenko, NL; Vesnina, L. E.; Кайдашев, І П

doi:10.15407/fz58.02.033

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Therefore, it is highly important to draw the attention of future medical professionals to the Latin terms and expressions that are used in case reports most frequently. It is our belief that the use of Latin in MCRs requires further examination in other scholarly journals that are registered in PubMed and other databases [ 41 – 44 ], which will consequently enable the conduct of comparative studies of different academic periodicals and provide a deeper understanding of the role of Latin in modern medical discourse.…”

Section: Discussionmentioning

confidence: 99%

The use of Latin terminology in medical case reports: quantitative, structural, and thematic analysis

Бєляєва

2018

J Med Case Reports

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BackgroundThis paper focuses on the prevalence of Latin terms and terminological collocations in the issues of Journal of Medical Case Reports (February 2007–August 2017) and discusses the role of Latin terminology in the contemporary process of writing medical case reports.MethodsThe objective of the research is to study the frequency of using Latin terminology in English-language medical case reports, thus providing relevant guidelines for medical professionals who deal with this genre and drawing their attention to the peculiarities of using Latin in case reports. The selected medical case reports are considered, using methods of quantitative examination and structural, narrative, and contextual analyses.ResultsWe developed structural and thematic typologies of Latin terms and expressions, and we conducted a quantitative analysis that enabled us to observe the tendencies in using these lexical units in medical case reports. The research revealed that the use of Latin fully complies with the communicative strategies of medical case reports as a genre. Owing to the fact that Latin medical lexis is internationally adopted and understood worldwide, it promotes the conciseness of medical case reports, as well as contributes to their narrative style and educational intentions.ConclusionsThe adequate use of Latin terms in medical case reports is an essential prerequisite of effective sharing of one’s clinical findings with fellow researchers from all over the world. Therefore, it is highly important to draw students’ attention to Latin terms and expressions that are used in medical case reports most frequently. Hence, the analysis of structural, thematic, and contextual features of Latin terms in case reports should be an integral part of curricula at medical universities.

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Section: Discussionmentioning

confidence: 99%

The use of Latin terminology in medical case reports: quantitative, structural, and thematic analysis

Бєляєва

2018

J Med Case Reports

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“…In addition, harmful neuroinflammatory reactions can be exacerbated by the activation of TLR4 (26). Moreover, the expression of NF-κB can be positively regulated by TLR4, but negatively regulated by PPAR-γ (27,28). The present results suggested that inflammatory factors were inhibited by PPAR-γ via mTOR suppression; thus, the relationship between TLR4 and mTOR may be crucial in the regulation of neuroinflammation.…”

Section: Discussionmentioning

confidence: 58%

Expression of TNF‑α and IL‑β can be suppressed via the PPAR‑γ/mTOR signaling pathway in BV‑2 microglia: A potential anti‑inflammation mechanism

et al. 2020

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currently, microglia are considered as crucial factors in suppressing inflammatory reactions, but the specific molecular mechanism remains unknown. To elucidate whether peroxisome proliferator-activated receptor-γ (PPar-γ) can inhibit neuroinflammatory cytokine expression via the mTOR signal pathway, the BV-2 cell line was incubated with lipopolysaccharide (10 mM/ml) to induce an inflammatory injury. PPAR-γ was activated by rosiglitazone, and was inhibited by GW9662. The mTOR signal pathway was activated by phosphatidic acid (P.A.), while it was inhibited by rapamycin. Western blotting and reverse transcription-quantitative PCR were used to evaluate the expression levels of PPAR-γ/mTor signal pathway related proteins and neuroinflammatory cytokines, including NF-κB, tumor necrosis factor (TNF)-α and interleukin (IL)-1β. When treated with P.A., the expression levels of phosphorylated (p)mTOR and p-ribosomal protein S6 kinase (pS6K) were significantly increased and the expression levels of TNF-α and il-1β were significantly lower. However, the expression of PPAR-γ was similar in P.A. treated cells and cells treated with rapamycin. When PPAR-γ was activated, pmTOR and pS6K protein expression levels were significantly decreased, and the mRNA expression levels of TNF-α and il-1β were significantly reduced, but this inhibition could be alleviated by administrating GW9662. Collectively, it was indicated that the mTOR signal pathway may be located downstream of PPar-γ. Furthermore, neuroinflammatory reactions could be inhibited via the activation of PPAR-γ by suppressing the mTOR signal pathway in microglia.

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“…Pioglitazone can reduce TLR2 and TLR4 expression in human monocytes, blocking NF-κB activation and cytokine production ( Dasu et al., 2009 ; Kutsenko et al., 2012 ). To investigate whether pioglitazone affects SLA-stimulated PBMCs through PPAR-γ, we blocked PPAR-γ signaling with a selective and irreversible inhibitor and later stimulated these cells with SLA and pioglitazone ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

Pioglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Downregulates the Inflammatory Response in Cutaneous Leishmaniasis Patients Without Interfering in Leishmania braziliensis Killing by Monocytes

Nascimento

Cordeiro

Abreu

et al. 2022

Front. Cell. Infect. Microbiol.

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Patients with cutaneous leishmaniasis (CL) due to Leishmania braziliensis infection have an exacerbated inflammatory response associated with tissue damage and ulcer development. An increase in the rate of patients who fail therapy with pentavalent antimony has been documented. An adjuvant therapy with an anti-inflammatory drug with the potential of Leishmania killing would benefit CL patients. The aim of the present study was to investigate the contribution of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation by pioglitazone in the regulation of the inflammatory response and L. braziliensis killing by monocytes. Pioglitazone is an oral drug used in the treatment of diabetes, and its main mechanism of action is through the activation of PPAR-γ, which is expressed in many cell types of the immune response. We found that activation of PPAR-γ by pioglitazone decreases the inflammatory response in CL patients without affecting L. braziliensis killing by monocytes. Our data suggest that pioglitazone may serve as an adjunctive treatment for CL caused by L. braziliensis.

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Pioglitazone, an activator of PPAR-gamma, reduces the expression of kB nuclear factor and inhibits apoptosis in mononuclear cells of peripheral blood in vitro

Cited by 8 publications

References 15 publications

The use of Latin terminology in medical case reports: quantitative, structural, and thematic analysis

The use of Latin terminology in medical case reports: quantitative, structural, and thematic analysis

Expression of TNF‑α and IL‑β can be suppressed via the PPAR‑γ/mTOR signaling pathway in BV‑2 microglia: A potential anti‑inflammation mechanism

Pioglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Downregulates the Inflammatory Response in Cutaneous Leishmaniasis Patients Without Interfering in Leishmania braziliensis Killing by Monocytes

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