Pioglitazone HCl Levels and Its Pharmacokinetic Application in Presence of Sucralose in Animals Serum by HPLC Method

Tamimi, Lina; Dayyih, Wael Abu; Qinna, Nidal A.; Mallah, Eyad; Arafat, Tawfiq

doi:10.4172/2153-2435.1000318

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Recently published data have proven that using plant extracts or plant-based beverages with medications has been shown to inhibit biochemical processes in the intestine, leading to altered pharmacokinetics and pharmacodynamics outcomes. [13] Liquorice (LIQ, Glycyrrhiza glabra of the Leguminosae Family) is a well-known and most widely consumed traditional drink, particularly in the Middle East region [14]. Most of the beneficial effects of LIQ come from its roots and rhizomes, which have been used alone or in combination with other herbs to treat a wide variety of conditions, including those related to the digestive system (such as stomach ulcers, flatulence, hyperdipsia, and colic) and the respiratory system (tonsillitis, asthma, coughs, sore throat, and jaundice) [15][16][17][18].…”

Section: Esmo Bis(5-methoxy-2-[(s)-[(4-methoxy-35dimethyl-2-pyridinyl...mentioning

confidence: 99%

Effects of Liquorice Juice on the Pharmacokinetics of Esomeprazole

2023

JPTCP

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The HPLC-MS technique was tested and verified in this work to quantify esomeprazole in rat plasma samples. A rat investigation demonstrated that co-administration of a single dosage of liquorice juice had no effect on the pharmacokinetic characteristics of esomeprazole, however successive doses of liquorice juice raised the t1/2 and area under the curve of esomeprazole. After introducing liquorice juice into the stomach, the pharmacokinetics of esomeprazole was determined simultaneously by HPLC-MS. The absorption of esomeprazole was rapid; esomeprazole was detected in plasma from the first blood sampling time, and the peak plasma concentration for the esomeprazole-treated group with multiple doses of liquorice was reached one hour after oral administration. At the same time, peak plasma concentration was reached 30 min after oral administration for the esomeprazole-treated group with a single dose of liquorice or distilled water. The plasma concentrations of esomeprazole in the esomeprazole-treated group with single-dose liquorice were comparable to those with single-dose distilled water. The plasma concentrations of esomeprazole were higher in the esomeprazole treated group with multiple doses of liquorice than in the esomeprazole treated group with single-dose distilled water, resulting in a significantly higher AUC, 2.5 times, in the esomeprazole treated group with multiple doses of liquorice. This could be due to decreased metabolism of esomeprazole by multiple doses of liquorice. Since esomeprazole is metabolized in the liver mainly by CYP2C19 and liquorice is a moderate inhibitor of CYP2C19 in humans there was an inhibition of CYP2C19 at multiple doses of liquorice. The inhibited metabolism of esomeprazole by liquorice resulted in a significantly higher Cmax, 1.5 times, and a significantly longer terminal half-life, 1.45 times, than in the control group. Therefore, multiple administration of liquorice could increase the esomeprazole effect since a single dose did not affect esomeprazole metabolism.

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Section: Esmo Bis(5-methoxy-2-[(s)-[(4-methoxy-35dimethyl-2-pyridinyl...mentioning

confidence: 99%

Effects of Liquorice Juice on the Pharmacokinetics of Esomeprazole

2023

JPTCP

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“…The separation was under the following conditions: flow rate: 1.0 mL per min, column: ACE C18 (250 mm × 4.6 mm), 5 µm, detector wavelength: 230 nm, column temperature: 25 O C, injection volume: 10 µL, run time: 5.0 min, diluent: mobile phase: 30 : 70 (buffer: acetonitrile) The retention time under these conditions was equal to 2.14 which give a sharp peak with good symmetry for Metformin, Alogliptin: 3.22 and Pioglitazone: 3.57 (7).…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

A Stability Indicating RP-HPLC Method Development for Simultaneous Estimation of Alogliptin, Pioglitazone, and Metformin in Finished Pharmaceutical Formulations

Habash¹,

Al-Shdefat²,

Hailat³

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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Alogliptin, dipeptidyl peptidase-4 (DPP-4) inhibitor, Pioglitazone, thiazolidinediones (TZDs) and Metformin, biguanides are antidiabetic drugs that usually used in the management of type 2 diabetes that can be used solely or as combinations. In this article, a selective, simple, economical, precise, and stability-indicating RP-HPLC method has been developed and validated for assessing Alogliptin, Pioglitazone, and Metformin inside the bulk drug and tablet pharmaceutical dosage form. The mobile phase that used to separate the drug was consists of acetonitrile: buffer (potassium dihydrogen phosphate), (30 : 70 v/v) on an ACE C18 ñ (250 mm × 4.6 mm), 5 µm column at a flow rate of 1.0 mL/min at 25 O C and detection was at 230 nm. The linearity of the detector was established in concentrations ranging from 20-250 ppm; the regression coefficient was 0.9998. The ICH guidelines were followed to evaluate stability, where the API is stressed by acid, base, neutral, oxidation, and sunlight. Several parameters were used for validation, including linearity, precision, accuracy, the limit of detection, and limit of quantification. The results were fulfilling expectations based on ICH guidelines. Robustness of the method was verified in terms of changes in pH of the mobile phase, detector wavelength, mobile phase composition, and temperature. Also, the method results in low relative standard deviation and high recovery value, that ensure the convenience applicability of the method for routine analysis of tablet containing Alogliptin, Pioglitazone, and Metformin.

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Influence of Energy Drinks on Pharmacokinetic Parameters of Sildenafil in Rats

Abdulla

Mallah

Dayyih

et al. 2018

Biomed. Pharmacol. J.

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Both sildenafil and RED BULL®(energy drink) are claimed to boost up energy.RED BULL®, one of the most commonly used energy drinks and its easily and widely available for daily use, the idea of this research work had arisen from observations about the concomitant use of sildenafil with RED BULL® by men seeking for better sexual performance. To study the effect of RED BULL® on the pharmacokinetic profile of sildenafil by using HPLC.The pharmacokinetic parameters (Cmax, Tmax and AUC) were determined in 10 rats following oral administration of 0.57 mg/ml sildenafil with and without RED BULL® in crossover design, to achieve this purpose,simple, rapid and accurate method for validation and determination of sildenafil in rat plasma in the presence of RED BULL® has been developed. This was performed using High-Performance Liquid Chromatography- Ultra Violet (HPLC-UV). The pharmacokinetic data showed that sildenafil plasma level was lower when combined with RED BULL® According to the results obtained, maximum concentration (Cmax) for sildenafil alone was (162.05 ng/ml) after 0.5 hours of administration. The Cmax decreased to (44.68 ng/ml) after 0.5 hoursof administration RED BULL® concomitantly with sildenafil which showed a significant effect on sildenafil plasma level (P<0.001). The area under the curve (AUC) decreased significantly from (370.53 ng/ml*hr) for sildenafil alone to (87.74 ng/ml*hr) when combined with RED BULL®. RED BULL® can alter sildenafil pharmacokinetic if they were taken together.

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Pioglitazone HCl Levels and Its Pharmacokinetic Application in Presence of Sucralose in Animals Serum by HPLC Method

Cited by 4 publications

References 19 publications

Effects of Liquorice Juice on the Pharmacokinetics of Esomeprazole

Effects of Liquorice Juice on the Pharmacokinetics of Esomeprazole

A Stability Indicating RP-HPLC Method Development for Simultaneous Estimation of Alogliptin, Pioglitazone, and Metformin in Finished Pharmaceutical Formulations

Influence of Energy Drinks on Pharmacokinetic Parameters of Sildenafil in Rats

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