2024
DOI: 10.1111/acer.15300
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Pioglitazone reverses alcohol‐induced alterations in alveolar macrophage mitochondrial phenotype

Kathryn M. Crotty,
Shayaan A. Kabir,
Sarah S. Chang
et al.

Abstract: BackgroundPeople with alcohol use disorder (AUD) have an increased risk of developing pneumonia and pulmonary diseases. Alveolar macrophages (AMs) are immune cells of the lower respiratory tract that are necessary for clearance of pathogens. However, alcohol causes AM oxidative stress, mitochondrial damage and dysfunction, and diminished phagocytic capacity, leading to lung injury and immune suppression.MethodsAMs were isolated by bronchoalveolar lavage from people with AUD and male and female C57BL/6J mice gi… Show more

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