Pionefrosis por Lelliottia amnigena

Guerra, Javier Miguel Martín; Asenjo, Miguel Martín; Gutiérrez, Carlos

doi:10.1016/j.medcli.2018.01.011

Cited by 6 publications

(5 citation statements)

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“…Members of the genus Lelliottia are rod-shaped, motile and facultative anaerobic Gram-negative bacilli ( Liu and Tang, 2016 ). L. amnigena was suspected to be pathogenic in humans since it was first isolated in nature, which was confirmed when it was isolated in samples from at least four patients whose clinical laboratory results indicated ( Martin Guerra et al, 2018 ). Lelliottia amnigena can be isolated from a variety of environmental sources (e.g., soil, river/lake; Rd et al, 1985 ), food (e.g., milk, mushrooms, artisanal raw cheeses) ( Yuk et al, 2018 ) and human clinical samples (e.g., respiratory tract, wound, blood, and stool samples).…”

Section: Introductionmentioning

confidence: 93%

Characterization and identification of a novel chromosomal class C β-lactamase, LAQ-1, and comparative genomic analysis of a multidrug resistance plasmid in Lelliottia amnigena P13

Yan

Zhang

et al. 2022

Front. Microbiol.

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IntroductionLelliottia amnigena, a bacterium usually isolated from natural environments, may cause human infections and has been suggested to be naturally resistant to second- and third-generation cephalosporins.MethodsIn this study, we determined the whole-genome sequence of an isolate, L. Amnigena P13, isolated from animal farm sewage. On the basis of genome sequence analysis, susceptibility testing, molecular cloning, and enzyme kinetic parameter analysis, we identified a novel chromosome-encoded AmpC β-lactamase, LAQ-1.Results and DiscussionblaLAQ-1 is resistant to penicillin G, ampicillin, and several first- to fourth-generation cephalosporins, such as cefazolin, cefoxitin and cefepime. The MIC levels of some β-lactams, such as cefoxitin, cefepime, aztreonam and cefazolin, for the recombinant clone (pUCP24-blaLAQ-1/DH5α) increased by approximately 4- to 64-fold compared with those of the control strain (pUCP24/DH5α). The kinetic properties of LAQ-1, with the highest catalytic activity observed toward piperacillin, were basically the same as those of typical class C β-lactamases, and avibactam had a strong inhibitory effect on its hydrolytic activity. The genetic background of blaLAQ-1 was relatively conserved, and no mobile genetic element (MGE) was found around it. The plasmid pP13-67 of L. amnigena P13 harbored 12 resistance genes [qnrS1, aph(6)-Id, aadA2, sul1, sul2,blaTEM-1, qacEΔ1, dfrA12, tetA and floR] related to different mobile genetic elements within an ~22 kb multidrug resistance region. The multidrug resistance region shared the highest nucleotide sequence similarities with those of the chromosomes or plasmids of different bacterial species, indicating the possibility of horizontal transfer of these resistance genes among different bacterial species.

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Section: Introductionmentioning

confidence: 93%

Characterization and identification of a novel chromosomal class C β-lactamase, LAQ-1, and comparative genomic analysis of a multidrug resistance plasmid in Lelliottia amnigena P13

Yan

Zhang

et al. 2022

Front. Microbiol.

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“…L. amnigena , as previously mentioned, was reported in a few case reports of infections in humans, e.g., unilateral posttraumatic endophthalmitis in an immunocompetent patient [ 4 ], which was a case of urinary tract infection in a patient immunosuppressed known to have prostatic and colorectal adenocarcinoma, with obesity, nephrolithiasis, and nephrostomy [ 5 ]; a case of pyonephrosis [ 6 ], involving an infection in a heart transplant recipient [ 12 ]; and sepsis in a case report from Ethiopia [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lelliottia amnigena , originally named Enterobacter amnigenus in 1981 [ 1 ], subsequently from 2013 known as L. amnigena after Brady et al [ 2 ], is a Gram-negative, facultative anaerobic bacillus identified from water sources and later from food (onions, cream, unpasteurized milk, and Spanish pork sausages) [ 3 ], which, under certain circumstances, can cause infections in humans. Few cases of human infections have been reported in the literature, such as endophthalmitis [ 4 ], urinary tract infection [ 5 ], pyonephrosis [ 6 ], and sepsis [ 7 ], which occur particularly in immunocompromised patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Lelliottia amnigena and Pseudomonas putida Coinfection Associated with a Critical SARS-CoV-2 Infection: A Case Report

Birlutiu,

Dobritoiu

2023

Microorganisms

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Lelliottia amnigena is a Gram-negative facultative anaerobic bacillus identified from water sources and later from food (onions, cream, unpasteurized milk, and Spanish pork sausages), which, under certain circumstances, can cause infections in humans, especially in immunocompromised patients. Few cases of human infections have been reported in the literature, such as endophthalmitis, urinary tract infection, pyonephrosis, and sepsis. We describe the case of a 69-year-old Caucasian male patient who lives in an urban environment and presents himself to the emergency department with chills, fever, myalgias, marked physical asthenia, dry cough, dyspnea, symptoms for which he is tested and confirmed with SARS-CoV-2 infection using real-time reverse transcriptase–polymerase chain reaction (RT-PCR) from nasal and pharyngeal swabs, after being admitted the same day (25 May 2023) to the Infectious Diseases Clinic from the County Clinical Emergency Hospital Sibiu, Romania. At the time of admission, a pulmonary computerized tomography (CT) scan was performed, which revealed a severity score of 10 out of 25. In the second week of the disease, the patient presents with hemoptysis, from which bacteriological examinations are carried out, and Pseudomonas putida and Lelliottia amnigena are identified. The evolution was slowly favorable under antiviral treatment, corticotherapy, antibiotic therapy (in the absence of the identified etiology, initially meropenem was administered in association with linezolid, and then ceftazidime-avibactam), voriconazole, anakinra, salbutamol inhaler, inhalation corticosteroids, with slow reduction in oxygen requirement, the patient continued oxygen therapy at home after discharge with a flow rate of 5 L/minute. During the third harvesting of sputum samples, P. putida was isolated along with L. amnigena, both strains of low-virulence species, and maintained susceptibility to antibiotics. In the context of an immunosuppressed patient with previous pulmonary surgery for actinomycosis, chronic obstructive pulmonary disease, and bronchiectasis, all these conditions are favorable for biofilm formation. L. amnigena remains a pathogen rarely isolated in human pathology, but we should pay more attention, especially in the immunosuppressed patient, where it can be responsible for an extremely serious clinical picture.

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“…Interest in L. amnigena is increasing as this bacterium has been associated with soft rot of economically important plant crops such as onion and potato [20]. Only rarely have L. amnigena and L. nimipressuralis been associated with opportunistic disease in humans [21][22][23][24]. There are few reports in the literature of the carriage of antimicrobial resistance (AMR) genes by Lelliottia spp., though a new chromosomally encoded AmpC β-lactamase, bla LAQ-1 , conferring resistance to ampicillin and several cephalosporins was recently described for an L. amnigena strain isolated from animal farm sewage in PR China [25,26].…”

Section: Introductionmentioning

confidence: 99%

Lelliottia amnigena recovered from the lung of a harbour porpoise, and comparative analyses with Lelliottia spp.

Negus,

Foster,

Hoyles

2023

Access Microbiology

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Strain M1325/93/1 (herein referred to by our laboratory identifier, GFKo1) of Lelliottia amnigena was isolated from the lung of a harbour porpoise in 1993. The genome sequence and antimicrobial resistance profile (genomic, phenotypic) of the strain were generated, with the genomic data compared with those from closely related bacteria. We demonstrate that the recently described chromosomally encoded AmpC β-lactamase bla LAQ is a core gene of L. amnigena , and suggest that new variants of this class of lactamase are encoded by other members of the genus Lelliottia . Although presence of bla LAQ is ubiquitous across the currently sequenced members of L. amnigena , we highlight that strain GFKo1 is sensitive to ampicillin and cephalosporins. These data suggest that bla LAQ may act as a useful genetic marker for identification of L. amnigena strains, but its presence may not correlate with expected phenotypic resistances. Further studies are required to determine the regulatory mechanisms of bla LAQ in L. amnigena .

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Pionefrosis por Lelliottia amnigena

Cited by 6 publications

References 4 publications

Characterization and identification of a novel chromosomal class C β-lactamase, LAQ-1, and comparative genomic analysis of a multidrug resistance plasmid in Lelliottia amnigena P13

Characterization and identification of a novel chromosomal class C β-lactamase, LAQ-1, and comparative genomic analysis of a multidrug resistance plasmid in Lelliottia amnigena P13

Lelliottia amnigena and Pseudomonas putida Coinfection Associated with a Critical SARS-CoV-2 Infection: A Case Report

Lelliottia amnigena recovered from the lung of a harbour porpoise, and comparative analyses with Lelliottia spp.

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