2020
DOI: 10.1101/2020.03.06.980706
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PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells

Abstract: StatementThis study reveals a novel mechanism underlying myogenesis defects in human rhabdomyosarcoma cells involving PIP3, whose depletion with PTEN rescues myoblast fusion defects.3 Abstract Myoblast fusion is required for myotube formation during myogenesis, and defects in myoblast differentiation and fusion have been implicated in a number of diseases, including human rhabdomyosarcoma. While the transcriptional regulation of the myogenic program has been studied extensively, the mechanisms controlling myob… Show more

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Cited by 3 publications
(2 citation statements)
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“…The approaches developed here have powerful applications beyond probing diffusion mechanisms. Chemically inducible dimerization systems have been widely used to spatiotemporally manipulate cellular architecture and signaling by recruiting proteins of interest (Rs of ≤ 5.8 nm) onto target sites in cells (Lin et al , 2013a ; Leyton‐Puig et al , 2016 ; Fan et al , 2017 ; Hong et al , 2018 ; Lian et al , 2020 ). The current study has established a new system that enables rapid recruitment of proteins of interest onto the centriolar lumen, pericentriolar matrix, or centriolar satellites within seconds.…”
Section: Discussionmentioning
confidence: 99%
“…The approaches developed here have powerful applications beyond probing diffusion mechanisms. Chemically inducible dimerization systems have been widely used to spatiotemporally manipulate cellular architecture and signaling by recruiting proteins of interest (Rs of ≤ 5.8 nm) onto target sites in cells (Lin et al , 2013a ; Leyton‐Puig et al , 2016 ; Fan et al , 2017 ; Hong et al , 2018 ; Lian et al , 2020 ). The current study has established a new system that enables rapid recruitment of proteins of interest onto the centriolar lumen, pericentriolar matrix, or centriolar satellites within seconds.…”
Section: Discussionmentioning
confidence: 99%
“…The approaches developed here have powerful applications beyond probing diffusion mechanisms. Chemically inducible dimerization systems have been widely used to spatiotemporally manipulate cellular architecture and signaling by recruiting proteins of interest (Rs of ≤ 5.1 nm) onto target sites in cells (18,(59)(60)(61). The current study has established a new system that enables rapid recruitment of proteins of interest onto the centrioles, pericentriolar matrix, or centriolar satellites within seconds.…”
Section: Discussionmentioning
confidence: 99%