Pipeline of Novel Antifungals for Invasive Fungal Disease in Transplant Recipients: A Pediatric Perspective
Alice Jenh Hsu,
Benjamin R Hanisch,
Brian T Fisher
et al.
Abstract:Invasive fungal disease (IFD) remains a significant cause of morbidity and mortality in children undergoing transplantation. There is a growing armamentarium of novel antifungal agents recently approved for use or in late stages of clinical development. The overarching goal of this review is to discuss the mechanisms of action, spectrum of activity, stage of development, and pediatric-specific data for the following agents: encochleated amphotericin B deoxycholate, fosmanogepix, ibrexafungerp, isavuconazole, o… Show more
Heterocyclic scaffolds, particularly pyridine-containing azaheterocycles, enjoy the legacy of being part of most of the approved drugs in the past decade. In the present perspective, we have explored the pyridine...
Heterocyclic scaffolds, particularly pyridine-containing azaheterocycles, enjoy the legacy of being part of most of the approved drugs in the past decade. In the present perspective, we have explored the pyridine...
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