Pipeline Spatial Data Model

Li, Zhenpei

doi:10.1007/978-3-030-24240-4_3

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…We also compared in vivo prenatal and organoid hair follicle cells with scRNA-seq data of adult hair follicles 14 . Our data can be explored interactively through our web portal which leverages WebAtlas 17 for intuitive visualisation and query (cell type and gene expression) of our single-cell, spatial and integrated datasets (https://developmental.cellatlas.io/fetal-skin; password: fs2023). The analysis software for this study is archived at Zenodo (https://doi.org/10.5281/zenodo.8164271).…”

Section: Resultsmentioning

confidence: 99%

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

Gopee,

Huang,

Olabi

et al. 2023

Preprint

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Human prenatal skin is populated by innate immune cells including macrophages, and whether they act solely in immunity or have additional functions in morphogenesis is unclear. We assembled the first comprehensive multi-omic reference atlas of prenatal human skin (7-16 post-conception weeks), combining single cell and spatial transcriptomic data, to characterise the skin's microenvironmental cellular organisation. This revealed that crosstalk between non-immune and immune cells underpins formation of hair follicles, has implications for scarless wound healing, and is critical for skin angiogenesis. We benchmarked a skin organoid model, derived from human embryonic stem (ES) and induced pluripotent stem (iPS) cells, against prenatal and adult skin, demonstrating close recapitulation of the epidermal and dermal skin components during hair follicle development. Notably, the skin organoid lacked immune cells and had markedly diminished endothelial cell heterogeneity and quantity. From our in vivo skin cell atlas data, we found that macrophages and macrophage-derived growth factors play a key role in driving endothelial development prenatally. Indeed, vascular network formation was enhanced following transfer of autologous iPS-derived macrophages into both endothelial cell angiogenesis assays and skin organoid cultures. In summary, innate immune cells moonlight as key players in skin morphogenesis beyond their conventional immune roles, a function they achieve via extensive crosstalk with non-immune cells. Finally, we leveraged our human prenatal skin cell atlas to further our understanding of the pathogenesis of genetic hair and skin disorders.

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Section: Resultsmentioning

confidence: 99%

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

Gopee,

Huang,

Olabi

et al. 2023

Preprint

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Justification of the Architecture a Promising Automated System for Monitoring Radiation, Chemical and Biological Environment Using Artificial Intelligence

Sharov,

Batinov,

Osipov

et al. 2024

jour

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The most progressive direction for identifying and assessing the chemical warfare situation is the introduction of technologies based on artificial intelligence. The goal of the work is to develop the architecture of a promising system for monitoring the radiation, chemical and biological situation using artificial intelligence. Research information base. Publications on the use of mathematical models in artificial intelligence (AI), available via the Internet. The research method is analytical, from general to specific. We considered the features of using artificial intelligence in automated control systems. Results and discussion. Confrontations with Ukraine and NATO are multivariate and spatial in nature, and require constant monitoring in the face of a lack of specific information about attacks being prepared and already carried out. The use of AI technologies will allow us to go beyond simply displaying the current situation, providing tools for predicting the development of events. The proposed architecture of a promising system involves the creation of a single database filled with verified information from open sources. The developed structure of the web application, which is an interactive interface for analyzing and responding to changes in the chemical warfare situation, will allow flexible switching between information layers and obtaining data in real time. Conclusion. The use of neural network technologies by NBC protection troops will make it possible to search according to specified parameters and conduct retrospective data analysis, which will significantly simplify monitoring of NBC threats for the troops and population of the Russian Federation.

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Pipeline Spatial Data Model

Cited by 2 publications

References 3 publications

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

Justification of the Architecture a Promising Automated System for Monitoring Radiation, Chemical and Biological Environment Using Artificial Intelligence

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