Piper nigrum: Therapeutic Potential of Leaves Extract in HNSCC

de Sousa, Stefanie Oliveira; Cardoso, Luana Pereira; Gusson-Zanetoni, Juliana Prado; Henrique, Tiago; Tajara, Eloiza Helena; Laurentiz, Rosangela Silva; Oliani, Sonia Maria; Rodrigues-Lisoni, Flávia Cristina

doi:10.29011/2574-710x.10150

Cited by 1 publication

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“…In order to better understand the mechanisms of cancer progression, some mediators (PTGS2 and PTGER4), which have been extensively studied by our research group previously, have been verified [ 34 , 35 ]. In addition, tumorigenic cells have a characteristic of uncontrolled growth, and it is known that as arachidonic acid derivatives participate in inflammation and are also closely linked to tumor development, with PTGS2 being highly expressed in hyperplastic tissues, the study of the genes of this inflammatory pathway is necessary in head and neck cancer [ 36 ]. Our results on gene expression indicate that piperine significantly reduced PTGS2 levels in the cells studied.…”

Section: Discussionmentioning

confidence: 99%

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Gusson-Zanetoni,

Cardoso,

de Sousa

et al. 2024

IJMS

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Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in the G2/M and S phases. A decrease in cell migration was also observed, and there was decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN-γ and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer.

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Section: Discussionmentioning

confidence: 99%