Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities

Sun, Xiaolei; Chen, Wenhua; Dai, Wei; Xin, Hailiang; Rahmand, Khalid; Wang, Yan; Zhang, Jiabao; Zhang, Shiyao; Xu, Lisha; Han, Ting

doi:10.1016/j.jep.2020.112897

Cited by 36 publications

(38 citation statements)

References 79 publications

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“…In other works, a study reported by Chieng et al (2008) proved that the myristicine isolated from P. sarmentosum leaves oil has significant inhibitory activity against subterranean termite namely Coptotermes sp. Additionally, the finding of methyleugenol in this study was validated by the reviews done by Sanusi et al (2017) and Sun et al (2020).…”

Section: Discussionsupporting

confidence: 84%

“…The presence of gallic acid, tannic acid, quercetin and naringenin in this study was supported the previous report by Rahman et al (2014b) and through RP-HPLC analysis. In addition, the reviews by Azelan et al (2020) and Sun et al (2020) also cited the presence of naringenin and quercetin in P. sarmentosum extract. According to several authors, P. sarmentosum is reported to contain the isolation of a number of amides and phenylpropanoids (Likhitwitayawuid et al, 1987;Masuda et al, 1991;Parmar et al, 1997;Stöhr et al, 1999;.…”

Section: Discussionmentioning

confidence: 99%

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Anti-acanthamoebic activity of methanolic extract of Piper sarmentosum leaves

Mustafa¹,

Ghazali²,

Mohamad³

et al. 2021

MJM

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Aims: Piper sarmentosum or locally known as Kaduk, is a tropical herb plant that was investigated for its phenolic content by previous researchers. The present study aimed at the analysis of crude methanolic extract of P. sarmentosum leaves for phenolic compounds identification and its anti-amoebic properties against pathogenic Acanthamoeba castellanii. Methodology and results: Folin-Ciocalteu assay was used to determine P. sarmentosum leaves methanolic extract (PSLME)'s total phenolic content (TPC). The extract was further characterized by using gas chromatography-mass spectrometry (GC-MS), reverse phase-high performance liquid chromatography (RP-HPLC) and liquid chromatographymass spectrometry (LC-MS) analyses to determine the chemical constituents in methanolic PSLME extract. The cytotoxicity of the extract was evaluated through the determination of inhibition concentration for half of cell population (IC50) of pathogenic A. castellanii followed by cell morphological analysis using inverted light and scanning electron microscopies. Acridine-orange/Propidium iodide (AOPI) staining was also conducted to determine the integrity of cell membrane for quantitative analysis. The results demonstrated that the TPC from PSLME was 142.72 mg [GAE]/g with a total of 33 phenolic compounds identified. The IC50 value obtained for A. castellanii was low (74.64 μg/mL) which indicates promising anti-acanthamoebic activity. Microscopy analyses showed that the plant extract caused cells encystment, in which exhibited by distinctive morphological changes on the cells shape and organelle, as well as shortening of acanthopodia. The dual staining and its quantitative analysis prove compromised membrane integrity in the treated amoeba. Conclusion, significance and impact of study: This finding provides the evidence that PSLME contains active phenolic compounds contributing to the anti-acanthamoebic activity on pathogenic Acanthamoeba species.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Anti-acanthamoebic activity of methanolic extract of Piper sarmentosum leaves

Mustafa¹,

Ghazali²,

Mohamad³

et al. 2021

MJM

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“…(Piperaceae), a low-growing perennial herb, has a long history of use as a source of potential herbal medicines and traditional cuisines. The plant is cultivated in America (Panama and North America), China (especially in southeast coastal areas), and Southeast Asian countries [1,2]. The whole plants, or specific parts of P. sarmentosum, such as roots, dry aerial parts, fruits, and leaves, have been used for medicine and human nutrition.…”

Section: Introductionmentioning

confidence: 99%

“…Its edible leaves possess an aromatic odor and pungent taste. Over the past three decades, P. sarmentosum has gained increasing research interest to assess its medicinal value in treating human health issues [2]. Furthermore, numerous studies have reported that P. sarmentosum leaves exhibit pharmacological Therefore, the selection of drying methods should be carefully considered to ensure that the precision and selectivity of the proposed analytical method are sufficient to detect significant changes in the tested plant material.…”

Section: Introductionmentioning

confidence: 99%

Development of a Simple High-Performance Liquid Chromatography-Based Method to Quantify Synergistic Compounds and Their Composition in Dried Leaf Extracts of Piper Sarmentosum Roxb.

Purba

Paengkoum

2021

Separations

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There is a growing demand to enhance pharmaceutical and food safety using synergistic compounds from Piper sarmentosum Roxb., such as polyphenols and water-soluble vitamins. However, information on standardized analytical methods to identify and quantify these compounds of interest is limited. A reversed-phase high-performance liquid chromatography with diode-array detection (HPLC-DAD)-based method was developed to simultaneously detect and quantify the amounts of tannin, flavonoid, cinnamic acid, essential oil, and vitamins extracted from P. sarmentosum leaves using methanol, chloroform, and hexane. Commercially and non-commercially-cultivated P. sarmentosum leaves were subjected to seven different drying treatments (shade; sun; air oven at 40 °C, 60 °C, 80 °C, and 100 °C; and freeze-drying) for three consecutive months. Most compounds were detected most efficiently at a detection wavelength of 272 nm. The developed method displayed good detection limits (LOD, 0.026–0.789 µg/mL; LOQ, 0.078–2.392 µg/mL), linearity (R2 > 0.999), precision (%RSD, <1.00), and excellent accuracy (96–102%). All P. sarmentosum leaf extracts were simultaneously tested and analytically compared without time-consuming fractionation. Methanolic plant extracts showed better peak area and retention time splits compared to chloroformic and hexanoic extracts. Differences in synergistic compound composition were dependent on the type of drying treatment but not on cultivation site and time of sampling. Flavonoid was identified as the dominant phytochemical component in P. sarmentosum leaves, followed by the essential oil, cinnamic acid, ascorbic acid, and tannin. Overall, we present a simple and reproducible chromatographic method that can be applied to identify different plant compounds.

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“…Low contents of this compound are described for the Piper, for example, in the P. sarmentosum Roxb. species, widely used in Asia for the treatment of cough, cold, fever, rheumatism, arthralgia, diarrhea, dysentery, postpartum swelling in the feet, stomach pain, toothache, diabetes, and traumatic injuries (Qin et al, 2010;Sun et al, 2020). It is worth noting that this compound is widely found in high contents in the roots of medicinal species of basal angiosperms, such as Asian Acorus calamus L. (25.4%) (Veteläinen et al, 2008) and in the stems of Aniba hostmanniana (Nees) Mez (98.6%) (Lauraceae) from tropical America (Gottlieb and Rocha, 1972).…”

Section: Discussionmentioning

confidence: 99%

Piper multinodum C.DC. (Piperaceae) essential oils chemical variation and biological activity against Mycobacterium tuberculosis

Ramos¹,

Costa-Oliveira²,

Fonseca³

et al. 2021

J. Med. Plants Res.

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Piper multinodum C.DC. belongs to the Piperaceae family, and is known as "Jaborandi-manso". This species has no reported botanical, chemical, pharmacological and/or toxicological scientific studies, and has restricted occurrence in degraded Brazilian biomes. The Piper genus is known to be aromatic, the essential oils (EO) obtained from different organs have demonstrated significant biological activities, and can be an important tool for chemophenetic and ecological definitions. The present study aimed to characterize the chemical profile of the EO from different parts of P. multinodum and their activity against Mycobacterium tuberculosis H 37 Rv (ATCC, 25618). The EO were obtained by hydrodistillation and characterized by GC-MS and GC-FID. Chemical composition of the volatile mixture showed a great diversity of compounds that diverged between the vegetative and reproductive parts. The α-pinene compound was identified as being the most predominant in the leaves, infructescences and inflorescences (32.49, 67.23 and 40.23%, respectively). The branches (secondary stem) showed to be rich in sesquiterpenes and monoterpenes: α-copaene (13.24%), E-caryophyllene (12.32%), α-pinene (20.34%), and myrcene (11.23%). The chemical profile of stems and roots showed a low percentage of monoterpenes and sesquiterpenes, but a high percentage of arylpropanoids, with E-methyl-isoeugenol (77.58%) registered in the stems and euasarone (81.34%) in the root. The antimycobacterial activity showed the highest activities recorded for the EO from roots (78.51 µg/mL) and infructescences (85.91 µg/mL). In addition to the findings related to biological activity, the determination of chemical diversification between the different parts of P. multinodum may help to understand the ecological issues of the Piperaceae family as well as to improve the chemotaxonomic knowledge of the genus Piper.

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Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities

Cited by 36 publications

References 79 publications

Anti-acanthamoebic activity of methanolic extract of Piper sarmentosum leaves

Anti-acanthamoebic activity of methanolic extract of Piper sarmentosum leaves

Development of a Simple High-Performance Liquid Chromatography-Based Method to Quantify Synergistic Compounds and Their Composition in Dried Leaf Extracts of Piper Sarmentosum Roxb.

Piper multinodum C.DC. (Piperaceae) essential oils chemical variation and biological activity against Mycobacterium tuberculosis

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