Antimicrob Agents Chemother
 2022
DOI: 10.1128/aac.01135-22
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Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy

Michaël Thy
1
,
Saı̈k Urien
2
,
Frantz Foissac
3
et al.

Abstract: We aimed to develop a piperacillin population pharmacokinetic (PK) model in critically ill children receiving continuous renal replacement therapy (CRRT) and to optimize dosing regimens. The piperacillin plasma concentration was quantified by high-performance liquid chromatography.

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