Piperacillin/Tazobactam (ZOSYN)

Culver, Stephanie M.; Martens, Mark G.

doi:10.1155/s1064744996000506

Infectious Diseases in Obstetrics and Gynecology

1996

DOI: 10.1155/s1064744996000506

|View full text |Cite

Piperacillin/Tazobactam (ZOSYN)

Stephanie M. Culver

Mark G. Martens

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2010

2016

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 11 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

Efficacy, pharmacokinetic and pharmacodynamic profile of ceftolozane + tazobactam in the treatment of complicated urinary tract infections

Wagenlehner

Alidjanov

2016

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

In vivo and vitro studies demonstrated high activity of ceftolozane+tazobactam in the combination of 2:1 against a variety of uropathogens, including ESBL-producers. Phase II and Phase III studies performed in patients with complicated UTIs showed good tolerability and safety of ceftolozane+tazobactam when prescribed intravenously 1.5 g every 8 h for 7 days and at least non-inferiority to a high dose (750 mg) of levofloxacin. The pharmacokinetics of ceftolozane+tazobactam makes it a worthy alternative to carbapenems in cases of complicated UTIs, also caused by multidrug resistant uropathogens.

show abstract

Efficacy, pharmacokinetic and pharmacodynamic profile of ceftolozane + tazobactam in the treatment of complicated urinary tract infections

Wagenlehner

Alidjanov

2016

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

show abstract

Structure, evolution and virtual screening of NDM-1 strain from Kolkata

Sahoo

Rani

Ansari

et al. 2014

IJBRA

View full text Add to dashboard Cite

β-lactam antibiotics are utilised to treat bacterial infection. β-lactamase enzymes (EC 3.5.2.6) are produced by several bacteria and are responsible for their resistance to β-lactam antibiotics like penicillin, cephamycins and carbapenems. New Delhi Metallo-β-lactamase (NDM-1) is a gene that makes bacteria resistant to β-lactam antibiotics. Preparing a compound against NDM-1 will require additional investment and development by drug manufacturers as the current antibiotics will not treat patients with NDM-1 resistance. NDM-1 of Kolkata showed convergent-type evolution with other NDM-1 producing strains. The modelled structure exhibited α-β-α barrel-type domain along with Zn metallo-β-lactamase N-terminal domain. Compounds belonging to cephalosporins (relatively resistant to β-lactamase) and other antibiotics ceftaroline, ceftobiprole, piperacillin, penamecillin, azidocillin, cefonicid, tigecycline and colistin have exhibited better binding affinity with the modelled NDM-1.

show abstract

Pharmacokinetic evaluation of piperacillin-tazobactam

Hayashi

Roberts

Paterson

et al. 2010

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Piperacillin/Tazobactam (ZOSYN)

Cited by 3 publications

References 11 publications

Efficacy, pharmacokinetic and pharmacodynamic profile of ceftolozane + tazobactam in the treatment of complicated urinary tract infections

Efficacy, pharmacokinetic and pharmacodynamic profile of ceftolozane + tazobactam in the treatment of complicated urinary tract infections

Structure, evolution and virtual screening of NDM-1 strain from Kolkata

Pharmacokinetic evaluation of piperacillin-tazobactam

Contact Info

Product

Resources

About