Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

“…Piperazine is an important scaffold associated with several biological activities (Shaquiquzzaman et al ., 2015; Singh et al ., 2015). Many synthetic piperazine derivatives have been reported to exhibit promising antifungal activity by causing the death of fungal cells (Moraca et al ., 2014; Thamban et al ., 2017).…”

Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer’s disease

“…Indandiones and their derivatives are an important class of bioactive molecules which possesses a broad spectrum biological activities such as anticoagulants, anti-microbial, analgesic, anticancer as well as antiviral activity. [15][16] On the other hand the piperazine scaffold is widely used to develop numerous biologically active agents such as antidepressants, anxiolytic, anticonvulsant, neuroprotective, antioxidant and anti-Alzheimer's. 17 To proceed with our goal, we have rationally designed a series of 2-(4-(4-substituted piperazin-1-yl)benzylidene)-1H-indene-1,3(2H)-diones which consists of indanone moiety, curcumin fragment as well as piperazine moiety inside one frame as shown in Figure 2.…”

“…Thereafter, the reaction mixture was poured into ice cold water and the precipitate that appeared was filtered and dried to accomplish formyl derivatives (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) in a yield of 80-90%.…”

The Synthesis and Singlet Oxygen Generation Study of 13(1)-N-Piperazinyl Chlorin e6-15(2),17(3)-Dimethyl Ester

“…[6] Thus, in this work we present the results of our efforts devoted to synthesis and the spectroscopic study of a new chlorin e 6 derivative containing a fragment of piperazine (Pz), which is a structural component of a number of antispasmodic, vermicidal and antitumor drugs. [13] It is reasonable to expect that double photodynamic and possible antimicrobial action of this conjugate (13(1)-N-piperazinyl chlorin e 6 15(2),17(3)-dimethyl ester, 1), which is structurally similar to famous PC based on the chlorin e 6 trimethyl ester platform (2), may be useful for clinical application at PDT. [7,10] …”