Piperidine Increase in the Brain of Dormant Mice

Stepita-Klauco, Matej; Doležalová, Hana; Fairweather, Robert B.

doi:10.1126/science.183.4124.536

Cited by 36 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally there are up to ten fold increases in the levels ofpiperidine in the brains of dormant, behaviourally asleep mice compared with awake animals (Stepita-Klauco et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

“…Piperidine has been shown to exert a tranquillizing effect in schizophrenia (Tasher et al, 1960) and to cause a prolongation of barbiturate-induced sleep (Kase et al, 1967). Additionally there are up to ten fold increases in the levels ofpiperidine in the brains of dormant, behaviourally asleep mice compared with awake animals (Stepita-Klauco et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A microiontophoretic study of the actions of the putative sleep factor, piperidine, in the rat brainstem

Horton

Logan

Wolstencroft

1985

British J Pharmacology

View full text Add to dashboard Cite

“…Additionally there are up to ten fold increases in the levels ofpiperidine in the brains of dormant, behaviourally asleep mice compared with awake animals (Stepita-Klauco et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A microiontophoretic study of the actions of the putative sleep factor, piperidine, in the rat brainstem

Horton

Logan

Wolstencroft

1985

British J Pharmacology

View full text Add to dashboard Cite

“…Piperidine (Pip) is a normal constituent of brain (1,2,3,4,5,6,7), skin (8,9) and urine (3,10) of mammals, and of the brain (11), cerebrospinal fluid (12), and urine (3,10,13) of humans, and of cerebral ganglia of molluscs (14). Pip shows potent nicotine-like actions on the peripheral (15,16,17) and central nervous systems (CNS) (18,19).…”

mentioning

confidence: 99%

Metabolites of Piperidine in Rat Urine

Okano

Miyata

Hung

et al. 1978

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

Abstracts-Piperidine is one of pharmacologically active biogenic amines While two pathways for piperidine production have been reported, little is known about me tabolism of the compound.In the present study, piperidine and its hydroxylated, conjugated and unknown metabolites were detected in rat urine by radiochromato graphic analysis. Using GC-MS technique, it was confirmed that 3-hydroxypiperidine and 4-hydroxypiperidine are major metabolites of piperidine of either exogenous or endogenous origin. The findings substantiate the existence of a mechanism which inactivates piperidine in the living body, since both metabolites lack the potent phar macological activities as those induced by piperidine.

show abstract

Quantitative Massenspektrometrie in Biochemie und Medizin

Lehmann

Schulten

1978

Angew. Chem.

View full text Add to dashboard Cite

Der vorliegende Aufsatz gibt einen uberblick iiber den Stand der quantitativen Analyse mit dem Massenspektrometer in Biochemie und Medizin. Die Grundlagen dafur, die gekoppelte Anwendung chromatographischer und massenspektrometrischer Methoden, die Entwicklung empfindlicher, genauer und iiberdies spezifischer massenspektrometrischer Nachweismethoden sowie das Prinzip der Verdiinnung mit stabilen Isotopen werden an Beispielen erlautert. Die wichtigsten Anwendungsgebiete sind die Verfolgung der Pharmakokinetik von Arzneimitteln und aktiven Metaboliten, die Erforschung von Stoffwechselwegen, die Unterstiitzung und Spezifizierung medizinischer Diagnosen und schlieI3lich die Qualitatskontrolle einfacherer quantitativer Verfahren der klinischen Chemie.

show abstract

Piperidine Increase in the Brain of Dormant Mice

Abstract: During a 2-hour period of dormancy (sleep), piperidine is accumulated in the mouse brain.

Cited by 36 publications

References 18 publications

A microiontophoretic study of the actions of the putative sleep factor, piperidine, in the rat brainstem

A microiontophoretic study of the actions of the putative sleep factor, piperidine, in the rat brainstem

Metabolites of Piperidine in Rat Urine

Quantitative Massenspektrometrie in Biochemie und Medizin

Contact Info

Product

Resources

About