Piperidine nucleus in the field of drug discovery

Abstract

Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several important pharmacophoric features and are being utilized in different therapeutic applications. Main text Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents. Conclusions This review article sheds a light on the most recent studies proving the importance of piperidine nucleus in the field of drug discovery.

Efficient amine oxidation using metal–organic framework photocatalysts for aminoalkyl radical-mediated halogen-atom transfer

“…70,71 The reaction can also be carried out using Boc-protected azetidine and piperidine ( 27–28 ), which are important motifs in drug discovery. 72–74…”

Synthesis of Quinolones and Zwitterionic Quinolonate Derivatives with Broad-Spectrum Antibiotic Activity

“…These reagents were selected because they include piperidine and piperazine rings while barely altering the reactivity of the pyridine’s nitrogen. Piperidine and piperazine scaffolds are included in many drug structures [ 27 , 28 ].…”

“…These reagents were selected because they include piperidine and piperazine rings while barely altering the reactivity of the pyridine's nitrogen. Piperidine and piperazine scaffolds are included in many drug structures [27,28]. To know if this reaction was extensible to imidazolic derivatives, DMAP was substituted with 1-methylimidazole to obtain compound 13 following the same procedure.…”

Synthesis, spectroscopic, topological, hirshfeld surface analysis, and anti-covid-19 molecular docking investigation of isopropyl 1-benzoyl-4-(benzoyloxy)-2,6-diphenyl-1,2,5,6-tetrahydropyridine-3-carboxylate

“…Its compounds show a variety of biological activities viz; anticancer, antimicrobial, analgesic and anti-inflammatory agents. Piperidine and pyridine components are the most common heterocyclic fragments present in FDA approved drugs [ 7 ]. Instead of having a secondary amine group in the piperidine ring, the ring nitrogen substituted by alkyl, aryl, and carbonyl groups [ 8 ], acetyl or benzoyl group possesses more biological activity 9 , 10 .…”