Piperine inhibits cytokine production by human peripheral blood mononuclear cells

Chuchawankul, Siriporn; Khorana, Nantaka; Poovorawan, Yong

doi:10.4238/2012.march.14.5

Cited by 37 publications

(16 citation statements)

References 22 publications

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“…For example, it has been shown that dietary curcumin in mice suppresses CD4 + T cell proliferation and IL-2 production [43] while in vitro curcumin supplementation inhibits T cell activation [44], human peripheral blood mononuclear cell proliferation and IL-2 production [40,42], and IL-2 synthesis as well as IL-2 signaling in mouse CD4+ T cells [41]. Although little information is available for piperine in this regard, some studies have indeed suggested that piperine may inhibit T cell-related functions [19,45]. …”

Section: Discussionmentioning

confidence: 99%

Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit

Wang

Vanegas

et al. 2013

Nutr Metab (Lond)

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BackgroundObesity is associated with low-grade inflammation and impaired immune response. Caloric restriction (CR) has been shown to inhibit inflammatory response and enhance cell-mediated immune function. Curcumin, the bioactive phenolic component of turmeric spice, is proposed to have anti-obesity and anti-inflammation properties while piperine, another bioactive phenolic compound present in pepper spice, can enhance the bioavailability and efficacy of curcumin. This study sought to determine if curcumin could potentiate CR’s beneficial effect on immune and inflammatory responses in obesity developed in mice by feeding high-fat diet (HFD).MethodsMice were fed a HFD for 22 wk and then randomized into 5 groups: one group remained on HFD ad libitum and the remaining 4 groups were fed a 10% CR (reduced intake of HFD by 10% but maintaining the same levels of micronutrients) in the presence or absence of curcumin and/or piperine for 5 wk, after which CR was increased to 20% for an additional 33 wk. At the end of the study, mice were sacrificed, and spleen cells were isolated. Cells were stimulated with T cell mitogens, anti-CD3/CD28 antibodies, or lipopolysaccharide to determine T cell proliferation, cytokine production, and CD4+ T cell subpopulations.ResultsCompared to HFD control group, all CR mice, regardless of the presence of curcumin and/or piperine, had lower body weight and fat mass, lower levels of blood glucose and insulin, and fewer total spleen cells but a higher percentage of CD4+ T cells. Additionally, they demonstrated lower production of pro-inflammatory cytokines IL-1β and TNF-α, a trend toward lower IL-6, and lower production of PGE2, a lipid molecule with pro-inflammatory and T cell-suppressive properties. Mice with CR alone had higher splenocyte proliferation and IL-2 production, but this effect of CR was diminished by spice supplementation. CR alone or in combination with spice supplementation had no effect on production of cytokines IL-4, IL-10, IFN-γ, and IL-17, or the proportion of different CD4+ T cell subsets.ConclusionCR on an HFD favorably impacts both metabolic and immune/inflammatory profiles; however, the presence of curcumin and/or piperine does not amplify CR’s beneficial effects.

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Section: Discussionmentioning

confidence: 99%

Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit

Wang

Vanegas

et al. 2013

Nutr Metab (Lond)

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“…Silver nanoparticles strongly inhibited cytokine production, of INF-γ, IL-6, IL-8, IL-11, TNF-α and more weakly IL-5. The mechanism of anti inflammatory effect is due to cellular cytotoxicity a higher doses and also nano-silver was found to strongly effect the production of Th1cells that secrete the inflammatory cytokines IL-2, INF-γ which are involved in cellular immunity, and in chronic inflammatory disorders [17].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract

S¹

2015

J Nanomed Nanotechnol

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Introduction: Nanotechnology has emerged as an exciting approach in the drug development process and among the various nanoparticles, silver nanoparticles have been explored for its variety of medical applications. Phyto assisted synthesis of silver nanoparticles is an eco-friendly and cost effective method for the development of silver nanoparticles with additional properties conferred by the capping phytochemicals.

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“…Similarly, Wang-Sheng et al [30] reported that piperine inhibits LPS-induced TNF-α, IL-6, IL-1β, and prostaglandin E2 (PGE-2) production in BV2 microglial cells. In the human peripheral blood mononuclear cells (PBMCs), piperine was found to inhibit IL-2 and interferon gamma (IFN-È) [31]. Piperine inhibits the production of PGE2 and NO induced by LPS while decreasing TNF-α, inducible NO synthase (iNOS) and cyclooxigenase-2 (COX-2) in RAW264.7 cells, resulting in anti-inflammatory activity [32].…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

et al. 2019

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Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs.

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Piperine inhibits cytokine production by human peripheral blood mononuclear cells

Cited by 37 publications

References 22 publications

Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit

Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit

Evaluation of In-vitro Anti-Inflammatory Activity of Silver Nanoparticles Synthesised using Piper Nigrum Extract

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

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