Piperine inhibits the growth and motility of triple-negative breast cancer cells

Greenshields, Anna L.; Doucette, Carolyn D.; Sutton, Kimberly M.; Madera, Laurence; Annan, Henry George; Yaffe, Paul B.; Knickle, Allison; Dong, Zhibao; Hoskin, David W.

doi:10.1016/j.canlet.2014.11.017

Cited by 170 publications

(135 citation statements)

References 51 publications

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“…Paclitaxel may have different mechanism of cell apoptosis but earlier studies demonstrated reduced cytotoxicity in HER2 (human epidermal growth factor receptor 2) overexpressing breast cancer cells [38]. Recent studies demonstrated that piperine inhibited the growth of breast cancer cell lines in triple negative breast cancer [39], as well as those with estrogen receptorpositive breast cancer, via an antiproliferative effect and induction of caspase-dependent apoptosis [40]. Based on the above data and results, we hypothize that the mechanism of synergy interaction of the combinations of piperine and paclitaxel may involve an EGFR (epidermal growth factor receptor) signaling blockade.…”

Section: Discussionmentioning

confidence: 98%

Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

Motiwala

Rangari

2015

Synergy

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Section: Discussionmentioning

confidence: 98%

Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

Motiwala

Rangari

2015

Synergy

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“…A combination of piperine and γ radiation exerted more cytotoxicity for triple negative breast cancer cells than γ radiation alone. Piperine inhibited the growth of triple negative breast cancer xenografts in immune-deficient mice [189]. …”

Section: Black Pepper and Piperinementioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin. The main mechanisms of action include inducing apoptosis, inhibiting proliferation, migration and invasion of tumors, and sensitizing tumors to radiotherapy and chemotherapy. This review summarized recent studies on some spices for prevention and treatment of cancers, and special attention was paid to bioactive components and mechanisms of action.

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“…Recently, Zhang et al [25] demonstrated the chemopreventive abilities of piperine against two osteosarcoma cell lines (HOS and U-2OS) metastasis and Greenshields et al [40] demonstrated its protective properties against cancer cell migration in vitro through the inhibition of matrix metalloproteinase-2 and -9 expression.…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1

Cardoso

Vermelho

Lima

et al. 2016

Toxins

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Piperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic potential of feed-added piperine on broiler chickens experimentally intoxicated with AFB1, using micronucleus and comet assays. The antigenotoxicity assessment of 9-day-old chicks was performed on a total of 60 chickens divided into four groups of 15 broilers each: (C) control, (P) 60 mg·piperine kg−1 feed, (A) 0.5 mg·AFB1·kg−1 body weight, (daily by oral route), and (P + A) co-treatment with piperine and AFB1. The experiment was conducted for 26 days. Chicks intoxicated with AFB1 showed significant genotoxic effects in the first 24 h post intoxication, and the effects remained in the other periods analyzed (48, 72, and 96 h and 26 days of treatment). The DNA damage in peripheral blood cells, the number of erythrocytes with micronuclei, and polychromatic-to-normochromatic erythrocyte ratio were significantly reduced or absent in the piperine/AFB1 group. No significant differences were observed between the group piperine/AFB1 and the control and piperine-alone groups. The addition 60 mg·kg−1 of piperine to the diet of the broiler chicks was safe, promoting beneficial effects in poultry health with respect to the toxic effects 0.5 mg·AFB1·kg−1 body weight.

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Piperine inhibits the growth and motility of triple-negative breast cancer cells

Cited by 170 publications

References 51 publications

Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

Spices for Prevention and Treatment of Cancers

Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1

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