Piperine Promotes Glucose Uptake through ROS‐Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle

Maeda, Akiko; Shirao, Takeshi; Shirasaya, Daishi; Yoshioka, Yasukiyo; Yamashita, Yoko; Akagawa, Mitsugu; Ashida, Hitoshi

doi:10.1002/mnfr.201800086

Cited by 43 publications

(31 citation statements)

References 46 publications

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“…In addition, recent research findings showed evidence that suggests the ability of some alkaloids to mediate in the insulin‐signal transduction pathway, reverse molecular defects resulting in insulin resistance and glucose intolerance, and improve disease complications, in vitro and in vivo (Christodoulou et al, 2019). In this context, piperine promotes glucose uptake in skeletal muscles via ROS‐dependent activation of CAMMK/AMPK signaling pathway (Maeda et al, 2018). Treatment of diabetic rats with piperine caused a significant decrease in the concentration of blood sugar and increased insulin secretion (Kaur et al, 2016).…”

Section: Health Perspectivesmentioning

confidence: 99%

Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

234

106

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Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice, P. nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

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Section: Health Perspectivesmentioning

confidence: 99%

Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

234

106

View full text Add to dashboard Cite

show abstract

“…Piperine activates PPARγ, leading to inhibition of AKT/GSK3β and reduction of cardiac fibrosis [105]. As piperine phosphorylates AMP-activated protein kinase, facilitates glucose transporter 4 to enter the plasma membrane, increase the intracellular Ca2+ level and activation of Ca2+/calmodulin-dependent protein kinase kinase-beta, it also possesses hyperglycemia-preventing effect [106]. Piperine may act as a novel therapeutic agent for melanoma, as it increases the ratio of Bax and Bcl-2, upregulates the expression of apoptosis-inducing factor, and reduces UVB-induced p-glycoprotein activity in B16F10 mouse melanoma cells [73].…”

Section: Miscellaneous Activity-kinase Inflammation Diabetesmentioning

confidence: 99%

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

et al. 2019

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Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs.

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“…One member of this class in particular—CaMKK2—is able to phosphorylate Thr172 and may be activated by increase of Ca 2+ and ROS concentrations inside the cell [ 25 , 26 ]. It is found that presence of the piperine—an alkaloid widely present in food, can contribute to an increase of Ca 2+ and ROS concentrations inside the cell, hence activation of CaMKKβ [ 5 ].…”

Section: Structure and Activation Of Ampkmentioning

confidence: 99%

“…Reduced sensitivity to insulin and impaired glucose uptake leads to an increased level of total blood glucose. Since IR primarily affects skeletal muscle, liver and adipose tissue, it has a significant impact on energy-consuming metabolic pathways [1,3,5]. Many of existing biochemical pathways involved in human energy generation and consumption are proved to be modulated by AMPK (AMP-activated protein kinase)-key molecular target in treatment of metabolic syndrome and related abnormalities [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The role of AMPK in metabolism and its influence on DNA damage repair

et al. 2020

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One of the most complex health disproportions in the human body is the metabolic syndrome (MetS). It can result in serious health consequences such as type 2 diabetes mellitus, atherosclerosis or insulin resistance. The center of energy regulation in human is AMP-activated protein kinase (AMPK), which modulates cells’ metabolic pathways and protects them against negative effects of metabolic stress, e.g. reactive oxygen species. Moreover, recent studies show the relationship between the AMPK activity and the regulation of DNA damage repair such as base excision repair (BER) system, which is presented in relation to the influence of MetS on human genome. Hence, AMPK is studied not only in the field of counteracting MetS but also prevention of genetic alterations and cancer development. Through understanding AMPK pathways and its role in cells with damaged DNA it might be possible to improve cell’s repair processes and develop new therapies. This review presents AMPK role in eukaryotic cells and focuses on the relationship between AMPK activity and the regulation of BER system through its main component—8-oxoguanine glycosylase (OGG1).

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Piperine Promotes Glucose Uptake through ROS‐Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle

Abstract: Piperine in pepper prevents hyperglycemia by GLUT4 translocation through CaMKKβ/AMPK signaling via TRPV1-dependent increase in the intracellular Ca level and ROS generation.

Cited by 43 publications

References 46 publications

Piperine: A review of its biological effects

Piperine: A review of its biological effects

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

The role of AMPK in metabolism and its influence on DNA damage repair

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