Piperlongumine inhibits proliferation and oncogenic MYCN expression in chemoresistant metastatic retinoblastoma cells directly and through extracellular vesicles

Shi, Cui; Huang, Kunhui; Soto, John; Sankaran, Renuka P.; Kalia, Vandana; Onwumere, Onyekwere; Young, Michael; Einbond, Linda Saxe; Redenti, Stephen

doi:10.1016/j.biopha.2023.114554

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…Piperlongumine is well-known for its function as a senolytic substance, along with well-documented bioactivities, such as anti-inflammatory, antioxidant, and anticancer effects and anti-diabetic, anti-obesity, and neuroprotective properties (Go et al 2018 ; Henrique et al 2020 ; Dong et al 2021 ). Piperlongumine has been shown to regulate various cellular processes, including cell proliferation, differentiation, apoptosis, and autophagy (Chen et al 2019 ; Shi et al 2023 ). In addition, piperlongumine reportedly participates in regulating various signaling pathways, such as the MAPK, PI3 K/Akt, and NF-κB pathways, suggesting its potential as a therapeutic agent for various diseases (Chen et al 2015 ; Kumar and Agnihotri 2019 ; Kumar and Agnihotri 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells

Lee,

Kang,

Kim

et al. 2024

Animal Cells and Systems

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Section: Discussionmentioning

confidence: 99%

Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells

Lee,

Kang,

Kim

et al. 2024

Animal Cells and Systems

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Role of MYCN in Retinoblastoma: A Review of Current Literature

Vempuluru,

Maniar,

Bakal

et al. 2024

Survey of Ophthalmology

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Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives

Li,

Wang,

Zhao

et al. 2024

IJN

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Plant-derived exosome-like nanovesicles (PELNs) from edible plants, isolated by ultracentrifugation, size exclusion chromatography or other methods, were proved to contain a variety of biologically active and therapeutically specific components. Recently, investigations in the field of PELN-based biomedicine have been conducted, which positioned those nanovesicles as promising tools for prevention and treatment of several diseases, with their natural origin potentially offering superior biocompatibility and bioavailability. However, the inadequate targeting and limited therapeutic effects constrain the utility and clinical translation of PELNs. Thus, strategies aiming at bridging the gap by engineering natural PELNs have been of great interest. Those approaches include membrane hybridization, physical and chemical surface functionalization and encapsulation of therapeutic payloads. Herein, we provide a comprehensive overview of the biogenesis and composition, isolation and purification methods and characterization of PELNs, as well as their therapeutic functions. Current knowledge on the construction strategies and biomedical application of engineered PELNs were reviewed. Additionally, future directions and perspectives in this field were discussed in order to further enrich and expand the prospects for the application of engineered PELNs.

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Piperlongumine inhibits proliferation and oncogenic MYCN expression in chemoresistant metastatic retinoblastoma cells directly and through extracellular vesicles

Cited by 3 publications

References 76 publications

Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells

Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells

Role of MYCN in Retinoblastoma: A Review of Current Literature

Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives

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