Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression

Cheng, Xiaoli; Tian, Pan; Zheng, Wengzhong; Yan, Xuetao

doi:10.1002/cam4.3043

Cited by 16 publications

(14 citation statements)

References 34 publications

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“…Overexpression of circ-100338 promotes the proliferation of HCC through the miR-141-3p/ZEB1 axis. However, piplartine decreases expression of circ-100338, resulting in attenuated HCC proliferation ( 149 ). Si et al.…”

Section: Novel Implications Of Circrna In Hccmentioning

confidence: 99%

Review of novel functions and implications of circular RNAs in hepatocellular carcinoma

et al. 2023

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Hepatocellular carcinoma (HCC) is one of the most frequent malignancies, with high incidence and mortality. As the majority of HCC patients are diagnosed at an advanced stage and die of recurrence and metastasis, its pathology and new biomarkers are needed. Circular RNAs (circRNAs) are a large subclass of long non-coding RNAs (lncRNAs) with covalently closed loop structures and abundant, conserved, stable, tissue-specific expression in mammalian cells. CircRNAs exert multiple functions in HCC initiation, growth and progression, serving as promising biomarkers for diagnosis, prognosis and therapeutic targets for this disease. This review briefly describes the biogenesis and biological functions of circRNAs and elucidates the roles of circRNAs in the development and progression of HCC, especially regarding epithelial-mesenchymal transition (EMT), drug resistance and interactions with epigenetic modifications. In addition, this review highlights the implications of circRNAs as potential biomarkers and therapeutic targets for HCC. We hope to provide novel insight into the roles of circRNAs in HCC.

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Section: Novel Implications Of Circrna In Hccmentioning

confidence: 99%

Review of novel functions and implications of circular RNAs in hepatocellular carcinoma

et al. 2023

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“…Additionally, circRNAs have been proven and proposed to be related to several kinds of tumors. One research group revealed that high expression of circ-100338 could promote the proliferation of hepatocellular carcinoma cells [ 38 ]. In another study, Pang et al determined that circ_0072309 could retard the progression of NSCLC by inhibiting the expression of miR-580-3p [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group

Zhang

et al. 2021

Disease Markers

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Objective. Intracranial aneurysm (IA) is a fatal disease owing to vascular rupture and subarachnoid hemorrhage. Much attention has been given to circular RNAs (circRNAs) because they may be potential biomarkers for many diseases, but their mechanism in the formation of IA remains unknown. Methods. circRNA expression profile analysis of blood samples was conducted between patients with IA and controls. Overall, 235 differentially expressed circRNAs were confirmed between IA patients and the control group. The reliability of the microarray results was demonstrated by quantitative real-time polymerase chain reaction (qRT-PCR). Results. Of 235 differentially expressed genes, 150 were upregulated, while the other 85 were downregulated. Five miRNAs matched to every differential expression of circRNAs, and related MREs were predicted. We performed gene ontology (GO) analysis to identify the functions of their targeted genes, with the terms “Homophilic cell adhesion via plasma membrane adhesion molecules” and “Positive regulation of cellular process” showing the highest fold enrichment. Conclusions. This study demonstrated the role of circRNA expression profiling in the formation of IA and revealed that the mTOR pathway can be a latent therapeutic strategy for IA.

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“…circSHKBP1 is highly expressed in the serum of patients with gastric cancer, which is also correlated with the prognosis of patients with gastric cancer (111). The abnormal expression of hsa_circ_0051443 (115), hsa_circ_100338 (116), circ-ZEB1.33 (117) in the serum of HCC patients is related to the prognosis of HCC patients. The abnormal expression of hsa_circ_0000370 in the blood of CRC patients is associated with the prognosis of CRC patients (118).…”

Section: Clinical Application the Diagnostic And Prognostic Roles Of Circrnas In Gi Tumorsmentioning

confidence: 98%

Research Progress of Circular RNA in Gastrointestinal Tumors

Fang

Ding

et al. 2021

Front. Oncol.

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circular RNA (circRNA) is a closed ring structure formed by cyclic covalent bonds connecting the 5’-end and 3’-end of pre-mRNA. circRNA is widely distributed in eukaryotic cells. Recent studies have shown that circRNA is involved in the pathogenesis and development of multiple types of diseases, including tumors. circRNA is specifically expressed in tissues. And the stability of circRNA is higher than that of linear RNA, which can play biological roles through sponge adsorption of miRNA, interaction with RNA binding protein, regulation of gene transcription, the mRNA and protein translation brake, and translation of protein and peptides. These characteristics render circRNAs as biomarkers and therapeutic targets of tumors. Gastrointestinal tumors are common malignancies worldwide, which seriously threaten human health. In this review, we summarize the generation and biological characteristics of circRNA, molecular regulation mechanism and related effects of circRNA in gastrointestinal tumors.

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Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression

Cited by 16 publications

References 34 publications

Review of novel functions and implications of circular RNAs in hepatocellular carcinoma

Review of novel functions and implications of circular RNAs in hepatocellular carcinoma

Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group

Research Progress of Circular RNA in Gastrointestinal Tumors

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