Pirenoxine prevents oxidative effects of argon fluoride excimer laser irradiation in rabbit corneas: biochemical, histological and cytofluorimetric evaluations

Cantore, Miriam; Siano, Salvatore; Coronnello, Marcella; Mazzetti, Luca; Franchi‐Micheli, S.; Boldrini, E.; Ciuffi, Mario; Failli, Paola

doi:10.1016/j.jphotobiol.2004.09.005

Cited by 9 publications

(10 citation statements)

References 34 publications

(38 reference statements)

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“…Reactive species‐mediated cellular damage instigates lipid peroxidation and apoptosis throughout the cornea . Moreover, the detachment of epithelial cells from one another and their basement membrane in addition to alterations to the thickness of the epithelial layer may disrupt the integrity of this permeability barrier . Nuclear fragmentation is perceptible and mitochondrial DNA damage may diminish mitochondrial and subsequently cell viability by lowering the efficiency of oxidative phosphorylation, intensifying reactive oxygen species formation .…”

Section: Reactive Species Antioxidants and Oxidative Stress In The Nmentioning

confidence: 99%

“…95,[99][100][101][102] Moreover, the detachment of epithelial cells from one another and their basement membrane in addition to alterations to the thickness of the epithelial layer may disrupt the integrity of this permeability barrier. 83,103,104 Nuclear fragmentation is perceptible and mitochondrial DNA damage may diminish mitochondrial and subsequently cell viability by lowering the efficiency of oxidative phosphorylation, intensifying reactive oxygen species formation. [104][105][106] Stromal scarring manifests from a reparative response and causes haze from light scattering, 107,108 while covalent bonding disruptions in stromal matrix collagen and proteoglycan molecules may precede disorganisation and aggregation of the collagen fibres.…”

Section: Oxidative Stress and The Effects Of Antioxidantsmentioning

confidence: 99%

“…Aldehyde dehydrogenase decreases light scattering by precluding the aggregation of photolabile proteins, 118 while keratocyte apoptosis is averted by vitamin E. 121 Pirenoxine, a radical scavenger, attenuates reactive oxygen species overproduction and extracellular vacuolisation in the stroma and preserves stromal morphology and cell and mitochondrial viability. 103,122 Polymorphonuclear cell influx and myeloperoxidase activity is diminished by ascorbic acid, reducing inflammatory damage. 99,123 The quantity of the endogenous antioxidants glutathione peroxidase and superoxide dismutase are induced by a-lipoic acid.…”

Section: Oxidative Stress and The Effects Of Antioxidantsmentioning

confidence: 99%

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A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species‐associated processes

Cheung

McGhee

Sherwin

2013

Clinical and Experimental Optometry

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Severe loss of vision manifests from the corneal protrusion, thinning and distortion that characterises keratoconus, which in its most severe form is still treated primarily by lamellar or penetrating keratoplasty. Unfortunately, alternative therapeutic options targeting the underlying pathobiology remain limited, attributable to an incomplete understanding of the biological mechanisms instigating stromal deterioration and other disease processes. We postulate that underlying abnormalities in stromal repair and reactive species-linked activities and the interaction between these phenomena are implicated in the development of keratoconus. This revised interpretation of the pathophysiology may, with further investigation, advance our knowledge and the clinical management of this prevalent ectatic disorder.

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Section: Reactive Species Antioxidants and Oxidative Stress In The Nmentioning

confidence: 99%

Section: Oxidative Stress and The Effects Of Antioxidantsmentioning

confidence: 99%

Section: Oxidative Stress and The Effects Of Antioxidantsmentioning

confidence: 99%

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A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species‐associated processes

Cheung

McGhee

Sherwin

2013

Clinical and Experimental Optometry

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“…After liquid-phase separation (centrifugation at 2000 g for 10 min), the absorbance of the pink organic phase was spectrophotometrically evaluated at 532 nm and TBARS was expressed as nmoles of malondialdehyde (MDA)/10 mg of rat brain tissue (wet weight), using a curve with 1,1,3,3-tetramethoxypropane as the standard reference. 54 Computational Chemistry. Molecular modeling and graphics manipulations were performed using the SYBYL 55 and UCSF CHIMERA software packages, 56 running them on a Silicon Graphics Tezro R16000 workstation.…”

Section: General Procedures For the Synthesis Of 2-phenylpyrido[12-a]mentioning

confidence: 99%

Pyrido[1,2-a]pyrimidin-4-one Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors Exhibiting Antioxidant Activity

et al. 2007

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pyrimidin-4-one derivatives bearing a phenol or a catechol moiety in position 2 were tested as aldose reductase (ALR2) inhibitors and exhibited activity levels in the micromolar/submicromolar range. Introduction of a hydroxy group in position 6 or 9 gave an enhancement of the inhibitory potency (compare 18, 19, 28, and 29 vs 13 and 14). Lengthening of the 2-side chain to benzyl determined a general reduction in activity. The lack or the methylation of the phenol or catechol hydroxyls gave inactive (10-12, 21, 22, 25-27) or scarcely active (15, 17, 20) compounds, thus demonstrating that the phenol or catechol hydroxyls are involved in the enzyme pharmacophoric recognition. Moreover, all the pyridopyrimidinones displayed significant antioxidant properties, with the best activity shown by the catechol derivatives. The theoretical binding mode of the most active compounds obtained by docking simulations into the ALR2 crystal structure was fully consistent with the structure-activity relationships in the pyrido[1,2-a]pyrimidin-4-one series.

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“…Известно, что противокатарактальное действие пиреноксина включает в себя следующие основные механизмы: ингибирование действия хиноновых соединений (продуктов нарушенного метаболизма ароматических аминокислот в хрусталике) и замедление процесса денатурации (перехода растворимого белка хрусталика в нерастворимую форму); нормализацию обмена глюкозы в хрусталике и препятствие отложению сорбита; стабилизацию клеточных мембран [9][10][11][12]. Кроме того, ряд публикаций указывает на антиоксидантные свойства пиреноксина, связанные с его способностью ингибировать перекисное окисление липидов (в том числе в хрусталике млекопитающих), что обусловливает возможность его использования для профилактики катарактогенеза у пациентов после витрэктомии [11,12]. Вышеуказанные исследования проводились на лабораторных животных, однако в доступной научной литературе нам не удалось обнаружить данные о возможности использования пиреноксина в профилактике развития катаракты у пациентов после витрэктомии и удаления ЭРМ.…”

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Effectiveness of the Cataract Prevention in Patients with Epiretinal Membrane after Vitrectomy

Dashina¹,

Porhanov²,

Малышев

et al. 2020

Oftalʹmologiâ

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Purpose: tо evaluate effectiveness of cataractogenesis prophylaxis in patients with epiretinal membrane (ERM) after vitrectomy based on the pirenoxin use.Patients and мethods. The study included 72 patients (64.5 ± 6.4 years old; 31 men, 41 women) with ERM before and after 25G microinvasive vitrectomy with removal of ERM. The 1-st group patients (36 eyes) received pirenoxin instillation (Catalin®; 3 times a day, 6 months) in addition to the standard pharmacological support. The 2-nd group patients received only standard therapy. All patients underwent: standard ophthalmologic examination; lens state photoregistration with an assessment of lens opacities intensity (LOCS-III classification) with the calculation of the cataract development index (CDI). These were control points: examination before vitrectomy and 5 months after surgery. At control points, the incidence of lens opacities in the observation groups was also evaluated. Statistical analysis included: calculation of the mean and its standard deviation (M ± s); assessment of the significance of differences in control points with each group (Wilcoxon's T-test) and between groups (Mann—Whitney U-test); Pearson xi-square test.Results: In the 1-st group (pirenoxin instillation), 6 months after vitrectomy and ERM removal, the following indicators were noted: the initial cataract incidence was 5.6 %; CDI — 0.36 ± 0.03 points, increasing the maximum corrected visual acuity (MCVA) from 0.31 ± 0.03 to 0.6 ± 0.05. In the 2-nd group similar indicators significantly differed from the 1-st group data: the initial cataract incidence was 36.1 % (Pearson xi-square test > 3; p < 0.05); CDI — 3.1 ± 0.3 points (p < 0.01); the MCVA increase from 0.3 ± 0.05 to 0.43 ± 0.1 (p < 0.05).Conclusion. Pirenoxin (Catalin®) has demonstrated quite high efficacy in the cataract prevention in patients after vitrectomy with ERM removal.

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Pirenoxine prevents oxidative effects of argon fluoride excimer laser irradiation in rabbit corneas: biochemical, histological and cytofluorimetric evaluations

Cited by 9 publications

References 34 publications

A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species‐associated processes

A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species‐associated processes

Pyrido[1,2-a]pyrimidin-4-one Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors Exhibiting Antioxidant Activity

Effectiveness of the Cataract Prevention in Patients with Epiretinal Membrane after Vitrectomy

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