Pirfenidone as a potential antifibrotic injectable for Dupuytren’s disease

Panigrahi, Suchitra D.; Barry, Amanda; Multner, Scott; Kasting, Gerald B.; Figueroa, Julio Alberto Landero; Satish, Latha; Kumari, Harshita

doi:10.1080/10837450.2022.2038201

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…To obtain the drug release profiles, the loaded samples were placed into vials containing phosphate-buffered saline (PBS) at 37 °C and subjected to agitation on a horizontal shaker (100 rpm) (NB-2005LN Biotek, Winooski, VT, USA). The released molecules in the withdrawn bulk PBS were analyzed at predetermined time intervals by UV-Vis spectrophotometry (Evolution 220 model, Thermo Scientific, Waltham, MA, USA) at 310 nm for PFD [ 25 ], 545 nm for RB [ 17 ], and 208 nm for KR-12 [ 26 ].…”

Section: Materials and Methodsmentioning

confidence: 99%

Unraveling Drug Delivery from Cyclodextrin Polymer-Coated Breast Implants: Integrating a Unidirectional Diffusion Mathematical Model with COMSOL Simulations

Hernandez-Montelongo,

Salazar-Araya,

Mas-Hernández

et al. 2024

Pharmaceutics

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Breast cancer ranks among the most commonly diagnosed cancers worldwide and bears the highest mortality rate. As an integral component of cancer treatment, mastectomy entails the complete removal of the affected breast. Typically, breast reconstruction, involving the use of silicone implants (augmentation mammaplasty), is employed to address the aftermath of mastectomy. To mitigate postoperative risks associated with mammaplasty, such as capsular contracture or bacterial infections, the functionalization of breast implants with coatings of cyclodextrin polymers as drug delivery systems represents an excellent alternative. In this context, our work focuses on the application of a mathematical model for simulating drug release from breast implants coated with cyclodextrin polymers. The proposed model considers a unidirectional diffusion process following Fick’s second law, which was solved using the orthogonal collocation method, a numerical technique employed to approximate solutions for ordinary and partial differential equations. We conducted simulations to obtain release profiles for three therapeutic molecules: pirfenidone, used for preventing capsular contracture; rose Bengal, an anticancer agent; and the antimicrobial peptide KR-12. Furthermore, we calculated the diffusion profiles of these drugs through the cyclodextrin polymers, determining parameters related to diffusivity, solute solid–liquid partition coefficients, and the Sherwood number. Finally, integrating these parameters in COMSOL multiphysics simulations, the unidirectional diffusion mathematical model was validated.

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Section: Materials and Methodsmentioning

confidence: 99%

Unraveling Drug Delivery from Cyclodextrin Polymer-Coated Breast Implants: Integrating a Unidirectional Diffusion Mathematical Model with COMSOL Simulations

Hernandez-Montelongo,

Salazar-Araya,

Mas-Hernández

et al. 2024

Pharmaceutics

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show abstract

“…However, there is interest in developing a formulation for local administration (personal communication with FibroGen Inc research team), and precedence already exists for this strategy with other systemically administered antifibrotic pharmacotherapies, such as pirfenidone. 58 We anticipate the dosing would be significantly lower than what is being used for current systemic therapy in clinical applications. Second, the timing of Pamrevlumab treatment would need to be determined.…”

Section: A Role For Pamrevlumab In Dupuytren Disease?mentioning

confidence: 99%