Pirfenidone increases the epithelialization rate of skin graft donor sites

Mecott-Rivera, Gabriel A.; Aguilar-Baqueiro, Jorge Alejandro; Bracho, Stephano; Miranda-Maldonado, Ivette; Franco-Márquez, Rodolfo; Castro-Góvea, Yanko; Dorsey-Treviño, Edgar Gerardo; García-Pérez, Mauricio Manuel

doi:10.1016/j.burns.2018.07.007

Cited by 10 publications

(11 citation statements)

References 22 publications

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“…The animals were divided into four randomized groups: untreated group (WOT), control group using Kitoscell® (KC), CellPharma, CDMX, Mexico [ 9 ], and two experimental treated groups using 80 mg/mL and 160 mg/mL PB . The animals were anesthetized, the dorsal region was chemically shaved (Veet cream, Reckitt Benckiser, Slough, UK) and harvested, and four complete thickness excision surgeries of 1 cm 2 were performed [ 50 ].…”

Section: Methodsmentioning

confidence: 99%

“…It is used for the late remodeling phase of wound repair. Activities claimed by the pharmaceutical company also include the reduction of the inflammatory response, thereby controlling secondary edema and promoting a better blood supply [ 9 ]. Currently, no topically effective medication has been developed to accelerate the wound-healing process and/or prevent abnormal cicatrization.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

et al. 2022

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Wounds represent a medical problem that contributes importantly to patient morbidity and to healthcare costs in several pathologies. In Hidalgo, Mexico, the Bacopa procumbens plant has been traditionally used for wound-healing care for several generations; in vitro and in vivo experiments were designed to evaluate the effects of bioactive compounds obtained from a B. procumbens aqueous fraction and to determine the key pathways involved in wound regeneration. Bioactive compounds were characterized by HPLC/QTOF-MS, and proliferation, migration, adhesion, and differentiation studies were conducted on NIH/3T3 fibroblasts. Polyphenolic compounds from Bacopa procumbens (PB) regulated proliferation and cell adhesion; enhanced migration, reducing the artificial scratch area; and modulated cell differentiation. PB compounds were included in a hydrogel for topical administration in a rat excision wound model. Histological, histochemical, and mechanical analyses showed that PB treatment accelerates wound closure in at least 48 h and reduces inflammation, increasing cell proliferation and deposition and organization of collagen at earlier times. These changes resulted in the formation of a scar with better tensile properties. Immunohistochemistry and RT-PCR molecular analyses demonstrated that treatment induces (i) overexpression of transforming growth factor beta (TGF-β) and (ii) the phosphorylation of Smad2/3 and ERK1/2, suggesting the central role of some PB compounds to enhance wound healing, modulating TGF-β activation.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

et al. 2022

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“…The epithelial thickness was 98.21 ± 6 μm, compared to only 75.10 ± 60 μm in the control group (p = <0.05). 9 Whether this result was due to the pro-epithelializing effect of proper moisture control on wounds is unclear, but it does give evidence that pirfenidone is safe to use topically on wounds without the risk of excessive healing delays.…”

Section: Evidence Of Pirfenidone's Use In Dermatological Pathologiesmentioning

confidence: 99%

New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?

Cristodor¹,

Nechifor²,

Fotea³

et al. 2022

IJGM

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There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a similar mechanism of action, we also hypothesize that a similar medication, nintedanib, might have similar applications. We also propose that a liposomal technology may assist in the penetration of nintedanib and enhance its clinical effects.

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“…The animals were divided into four randomized groups: untreated group (WOT), control group using KitosCell®(KC), CellPharma [9], and two experimental Bacopa treated groups using 80 mg/ml and 160 mg/ml TAE. The animals were anesthetized, the dorsal region was chemically shaved (Veet cream, Reckitt Benckiser), harvested and four complete thickness excision surgeries of 1 cm2 were performed12.…”

Section: In Vivo Skin Wound Model 431 Animalsmentioning

confidence: 99%

“…It is used for the late remodeling phase of wound repair. Activities claim by the pharmaceutic company also includes the reduction of inflammatory response, thereby controlling secondary edema and promoting a better blood supply [9]. Nowadays, no topically effective medication has been developed to accelerate the wound healing process and/or to prevent abnormal cicatrization.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Polyphenolic Compounds from Bacopa Procumbens and Their Effects on Wound Healing Process

Martínez-Cuazitl¹,

Gómez-García²,

Hidalgo-Alegría³

et al. 2022

Preprint

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Wounds represents a medical problem that contribute importantly to patient morbidity and to the healthcare costs in several pathologies. In Hidalgo, Mexico, Bacopa procumbens plant has been traditionally used for wound healing care for several generations; in vitro and in vivo experiments were design to evaluate the effects of bioactive compounds obtained from B. procumbens aquoethanolic extract and to determine the key pathways involved in wound regeneration. Bioactive compounds were characterized by HPLC- QTOF-MS and proliferation, migration, adhesion, and differentiation studies were done on NIH/3T3 fibroblasts. Polyphenolic compounds from Bacopa procumbens (PB) regulated proliferation and cell adhesion; enhanced migration reducing the artificial scratch area; and modulated cell differentiation. PB compounds were included in a hydrogel for topical administration on rat excision wound model. Histological, histochemical and mechanical analysis showed that PB treatment accelerates wound closure in at least 48 h; reduce inflammation, increasing cell proliferation and deposition and organization of collagen in earlier times. These changes resulted in the formation of a scar with better tensile properties. Immunohistochemistry and RT-PCR molecular analyses demonstrated that treatment induces: i) overexpression of transforming growth factor beta (TGF-β); and ii) the phosphorylation of Smad 2/3 and ERK1/2, suggesting the central role of some PB to enhance wound healing, modulating TGF-β activation.

show abstract

Pirfenidone increases the epithelialization rate of skin graft donor sites

Cited by 10 publications

References 22 publications

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process

New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?

Characterization of Polyphenolic Compounds from Bacopa Procumbens and Their Effects on Wound Healing Process

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