Piriform Cortex and Amygdala

Martı́nez-Garcı́a, Fernando; Novejarque, Amparo; Gutiérrez-Castellanos, Nicolás; Lanuza, Enrique

doi:10.1016/b978-0-12-369497-3.10006-8

Cited by 36 publications

(71 citation statements)

References 155 publications

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“…The data available in the literature correspond to studies mainly performed in rats describing the efferent projections of some structures that project to the Pir, in some of which projections to the CxA can be observed (see, for a review, Martínez-García et al, 2012; Olucha-Bordonau et al, 2015). One recent study in rats obtained restricted injections in the CxA (Pro-Sistiaga et al, 2007), but reported only the resulting labeling in the olfactory bulbs.…”

Section: Discussionmentioning

confidence: 77%

“…At the level of the PLCo the CxA is no longer present. Therefore, for most of its rostrocaudal extent, the CxA is interposed between the ACo (medially) and the rostral aspect of the posterior Pir (see Martínez-García et al, 2012). In this regard, it is worth to note that the Pir is divided into a rostral part (or prepiriform area, see Haberly and Price, 1978a,b) characterized by the presence of the lateral olfactory tract and a clear limit with the olfactory tubercle, and a caudal part where the lateral olfactory tract is not observable and there is no clear-cut boundary with the CxA.…”

Section: Resultsmentioning

confidence: 99%

“…The local histochemical detection of acetyl cholinesterase activity clearly showed that the CxA was different from the adjacent piriform cortex (Pir) and neighboring amygdaloid structures (Paxinos and Watson, 1982). The same neurochemical feature allows distinguishing the CxA in the mouse brain (Paxinos and Franklin, 2004; Martínez-García et al, 2012). In addition to the acetyl cholinesterase reactivity, the CxA also shows a denser dopaminergic innervation than its adjacent piriform and amygdalar formations, as revealed by the immunohistochemical detection of tyrosine hydroxylase (Martínez-García et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…In the mouse brain, it appears rostrally together with the anterior amygdaloid area, and extends caudally until the appearance of the posterolateral cortical amygdaloid nucleus (PLCo). Therefore, in most of its extent the CxA is interposed between the ventral Pir and the anterior cortical amygdaloid nucleus (ACo) (Paxinos and Franklin, 2004; Martínez-García et al, 2012). It is worth to note that the CxA does not correspond to the piriform-amygdalar area of the Allen Brain Atlas, which is more caudally located, at the levels of the PLCo.…”

Section: Introductionmentioning

confidence: 99%

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Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

et al. 2016

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The transitional zone between the ventral part of the piriform cortex and the anterior cortical nucleus of the amygdala, named the cortex-amygdala transition zone (CxA), shows two differential features that allow its identification as a particular structure. First, it receives dense cholinergic and dopaminergic innervations as compared to the adjacent piriform cortex and amygdala, and second, it receives projections from the main and accessory olfactory bulbs. In this work we have studied the pattern of afferent and efferent projections of the CxA, which are mainly unknown, by using the retrograde tracer Fluorogold and the anterograde tracer biotinylated dextranamine. The results show that the CxA receives a relatively restricted set of intratelencephalic connections, originated mainly by the olfactory system and basal forebrain, with minor afferents from the amygdala. The only relevant extratelencephalic afference originates in the ventral tegmental area (VTA). The efferent projections of the CxA reciprocate the inputs from the piriform cortex and olfactory amygdala. In addition, the CxA projects densely to the basolateral amygdaloid nucleus and the olfactory tubercle. The extratelencephalic projections of the CxA are very scarce, and target mainly hypothalamic structures. The pattern of connections of the CxA suggests that it is indeed a transitional area between the piriform cortex and the cortical amygdala. Double labeling with choline acetyltransferase indicates that the afferent projection from the basal forebrain is the origin of its distinctive cholinergic innervation, and double labeling with dopamine transporter shows that the projection from the VTA is the source of dopaminergic innervation. These connectivity and neurochemical features, together with the fact that it receives vomeronasal in addition to olfactory information, suggest that the CxA may be involved in processing olfactory information endowed with relevant biological meaning, such as odors related to reproductive or defensive behaviors.

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Section: Discussionmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

et al. 2016

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“…Robust reciprocal connections have been shown between the amygdala and hippocampus in the rat (Pitkänen et al, 2000). In the mouse, data are more limited, but it is generally believed that there are no major species differences (Martínez-García et al, 2012;Witter, 2012). The potential importance of connections between amygdala and hippocampus at regulating emotional behaviours was recently demonstrated in a mouse study where optogenetic inhibition of the amygdaloid input to ventral hippocampus decreased anxiety-like behaviour (Felix-Ortiz et al, 2013).…”

Section: Introductionmentioning

confidence: 96%

Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice

2014

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The Olfactory Amygdala in Amniotes: An Evo‐Devo Approach

Abellán

Desfilis

Medina

2013

The Anatomical Record

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In tetrapods, the medial amygdala is a forebrain center that integrates olfactory and/or vomeronasal signals with the endocrine and autonomic systems, playing a key role in different social behaviors. The vomeronasal system has undergone important changes during evolution, which may be behind some interspecies differences in chemosensorymediated social behavior. These evolutionary changes are associated with variations in vomeronasal-recipient brain structures, including the medial amygdala. Herein, we employed an evolutionary developmental biology approach for trying to understand the function and evolution of the medial amygdala. For that purpose, we reviewed published data on fate mapping in mouse, and the expression of orthologous developmental regulatory genes (Nkx2.1, Lhx6, Shh, Tbr1, Lhx9, Lhx5, Otp, and Pax6) in embryos of mouse, chicken, emydid turtles, and a pipid frog. We also analyzed novel data on Lhx9 and Otp in a lacertid lizard. Based on distinct Abbreviations used: AAv 5 anterior amygdala, ventral part; ACo 5 anterior cortical amygdalar area; AHN 5 anterior hypothalamic nucleus; AOB 5 accessory olfactory bulb; AON 5 anterior olfactory nucleus; APH 5 parahippocampal area (chicken); Arc 5 arcopallium (part of the pallial amygdala in chicken); AStr 5 amygdalo-striatal transition area; BAOT 5 bed nucleus of the accessory olfactory bulb; Bas 5 basal nucleus (Meynert); BC 5 basal amygdalar complex; BL 5 basolateral amygdalar nucleus; BLA 5 basolateral amygdalar nucleus, anterior part; BLV 5 basolateral amygdalar nucleus, ventral part; BM 5 basomedial amygdalar nucleus; BMA 5 basomedial amygdalar nucleus, anterior part; BSTia 5 bed nucleus of the stria terminalis, intraamygdaloid part; BSTM 5 bed nucleus of the stria terminalis, medial part; BSTM1 5 dorsolateral subnucleus of BSTM (chicken); BSTM2 5 ventromedial subnucleus of BSTM (chicken); CDL 5 dorsolateral corticoid area (chicken); Ce 5 central amygdala (central amygdalar nucleus); Co 5 cortical amygdalar area (chicken, comparable to ACo of mammals); CPu 5 caudate-putamen; CxA 5 cortico-amygdalar transition area; DC 5 dorsal cortex (reptile); DEn 5 dorsal endopiriform nucleus; EMT 5 prethalamic (or thalamic) eminence; Ent 5 entorhinal cortex; Gaba1 5 g-aminobutyric acid (GABA)-ergic cells; Glu1 5 glutamatergic cells; GP 5 globus pallidus; GPL 5 globus pallidus, lateral part; GPM 5 globus pallidus, medial part; Hb 5 basal hypothalamus; Hip 5 hippocampal formation, rostral olfacto-recipient part; I 5 intercalated cell groups of the amygdale; ic 5 internal capsule; IM 5 intercalated cell groups of the amygdala, main division; L 5 lateral amygdalar nucleus; LC 5 lateral cortex (reptile); LGE 5 lateral ganglionic eminence; LOT 5 nucleus of the lateral olfactory tract; LOT1 5 nucleus of the lateral olfactory tract, layer 1; MC 5 medial cortex (reptile); Me 5 medial amygdala in nonmammals; MeA 5 medial amygdala, anterior part; MeAV 5 medial amygdala, anteroventral part; MePD 5 medial amygdala, posterodorsal part; MePV 5 medial amygdala, posteroven...

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Piriform Cortex and Amygdala

Cited by 36 publications

References 155 publications

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice

The Olfactory Amygdala in Amniotes: An Evo‐Devo Approach

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