2023
DOI: 10.3389/fgene.2023.1129194
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piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids

Abstract: piRNAs function as genome defense mechanisms against transposable elements insertions within germ line cells. Recent studies have unraveled that piRNA pathways are not limited to germ cells as initially reckoned, but are instead also found in non-gonadal somatic contexts. Moreover, these pathways have also been reported in bacteria, mollusks and arthropods, associated with safeguard of genomes against transposable elements, regulation of gene expression and with direct consequences in axon regeneration and mem… Show more

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Cited by 4 publications
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“…The evidence of an ancestral piRNA machinery that developed into a more complex and sophisticated form in multicellular eukaryotes could be reflected in the existence of PIWI-like machinery in Trypanosomatids and Apicomplexa. According to Horjales et al, ancient PIWI proteins were widely expressed and served purposes apart from germline preservation [18].…”
Section: Introductionmentioning
confidence: 99%
“…The evidence of an ancestral piRNA machinery that developed into a more complex and sophisticated form in multicellular eukaryotes could be reflected in the existence of PIWI-like machinery in Trypanosomatids and Apicomplexa. According to Horjales et al, ancient PIWI proteins were widely expressed and served purposes apart from germline preservation [18].…”
Section: Introductionmentioning
confidence: 99%