piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells

Cheng, Jia; Guo, Junming; Xiao, Bingxiu; Miao, Ying; Jiang, Zhen; Zhou, Hui; Li, Qingning

doi:10.1016/j.cca.2011.05.015

Cited by 287 publications

(273 citation statements)

References 24 publications

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“…PIWI family proteins have been shown to be aberrantly expressed and associated with poor prognosis in ovarian, colorectal, gastric, hepatocellular, esophageal, and pancreatic cancers (13)(14)(15)(16)(17)(18), and piRNA expression has been observed in bladder, colon, lung, cervical, breast, hepatocellular, and gastric cancers (19)(20)(21)(22)(23)(24). Our recent study also identified a genetic variant in a mature piRNA sequence that is associated with breast cancer risk (25).…”

Section: Introductionmentioning

confidence: 70%

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Jacobs

Qin

Lerro

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: PIWI-interacting RNAs (piRNAs), the largest class of noncoding RNAs in mammals, cooperate with PIWI proteins to safeguard the genome from insertional mutations during germline development. Although a growing number of studies have linked the PIWI-piRNA pathway to carcinogenesis, the role of piRNAs in glioma has not been explored.Methods: Utilizing directly measured and imputed genotypes from the GliomaScan genome-wide association study (1,840 cases and 2,401 controls), genetic variants in 1,428 piRNAs were analyzed for association with glioma risk. In vitro assays were performed to interrogate the functional impact of a top identified piRNA and its variant allele.Results: Variants in five piRNAs were considered to be associations of interest and four of these showed narrow clusters of enhanced association signals surrounding the index variant. Functional analyses of one of these piRNAs, piR-598, revealed that transfection of the wild-type piRNA impacted expression of

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Section: Introductionmentioning

confidence: 70%

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Jacobs

Qin

Lerro

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In HeLa cells, piRNAs, along with HILI protein, were found to play a role in LINE1 suppression (11). In gastric cancer tissue, piR-651 and piR-823 were found to be dysregulated (12,13). Specifically, the upregulation of piR-651 is associated with the clinical stage of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Although piRNAs have recently been shown to be present in somatic tissues and some human cancer cells, their functional significance is still not clear (8)(9)(10)(11). Recent studies have shown differential expression of piRNAs in gastric, liver and breast cancers (12,13). However, studies of piRNA expression in clear cell RCC (ccRCC) and its metastasis have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival

Gao

et al. 2015

Mol Med

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Piwi-interacting RNAs (piRNAs) are a distinct group of small noncoding RNAs (sncRNAs) that silence transposable genetic elements to protect genome integrity. Because of their limited expression in gonads and sequence diversity, piRNAs remain the most mysterious class of small RNAs. Studies have shown piRNAs are present in somatic cells and dysregulated in gastric, breast and liver cancers. By deep sequencing 24 frozen benign kidney and clear cell renal cell carcinoma (ccRCC) specimens and using the publically available piRNA database, we found 26,991 piRNAs present in human kidney tissue. Among 920 piRNAs that had at least two copies in one specimen, 19 were differentially expressed in benign kidney and ccRCC tissues, and 46 were associated with metastasis. Among the metastasis-related piRNAs, we found three piRNAs (piR-32051, piR-39894 and piR-43607) to be derived from the same piRNA cluster at chromosome 17. We confirmed the three selected piRNAs not to be miRNAs or miRNA-like sncRNAs. We further validated the aberrant expression of the three piRNAs in a 68-case formalin-fixed and paraffin-embedded (FFPE) ccRCC tissue cohort and showed the upregulation of the three piRNAs to be highly associated with ccRCC metastasis, late clinical stage and poor cancer-specific survival.

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“…These piRNAs function through the Piwi-Argonaute sub-family (AGO3, Aubergine and Piwi), leading to silencing of transposable elements. A link between piRNAs and cancer has been demonstrated in gastric cancers where two aberrantly expressed piRNAs, piRNA-651 and piRNA-823, were found in gastric tumour tissue versus paired normal tissue [95,96].…”

Section: Exosome-associated Rnamentioning

confidence: 99%

Exosome platform for diagnosis and monitoring of traumatic brain injury

Taylor

Gerçel-Taylor

2014

Phil. Trans. R. Soc. B

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We have previously demonstrated the release of membranous structures by cells into their extracellular environment, which are termed exosomes, microvesicles or extracellular vesicles depending on specific characteristics, including size, composition and biogenesis pathway. With activation, injury, stress, transformation or infection, cells express proteins and RNAs associated with the cellular responses to these events. The exosomes released by these cells can exhibit an array of proteins, lipids and nucleic acids linked to these physiologic events. This review focuses on exosomes associated with traumatic brain injury, which may be both diagnostic and a causative factor in the progression of the injury. Based on current data, exosomes play essential roles as conveyers of intercellular communication and mediators of many of the pathological conditions associated with development, progression and therapeutic failures and cellular stress in a variety of pathologic conditions. These extracellular vesicles express components responsible for angiogenesis promotion, stromal remodelling, signal pathway activation through growth factor/receptor transfer, chemoresistance, immunologic activation and genetic exchange. These circulating exosomes not only represent a central mediator of the pro-inflammatory microenvironment linked with secondary brain injury, but their presence in the peripheral circulation may serve as a surrogate for biopsies, enabling real-time diagnosis and monitoring of neurodegenerative progression.

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piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells

Cited by 287 publications

References 24 publications

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival

Exosome platform for diagnosis and monitoring of traumatic brain injury

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