Piroxicam and naproxen in acute sports injuries

Lereim, Paul; Gabor, I

doi:10.1016/0002-9343(88)90477-9

Cited by 18 publications

(4 citation statements)

References 2 publications

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“…Many clinical studies have been performed over the past 3 decades as various NSAIDs have become available. 1,5,8,14,15,19 Unfortunately, the data from these studies are difficult to interpret because different injuries and injury sites were used, many of the investigations did not use a placebo control, the subjective criteria varied, and the objective findings were often minimal or absent. However, the conclusion of the majority of reports in the literature is that, in ligament injuries, NSAIDs do decrease pain and swelling, compared with placebo, and also allow for earlier return of function.…”

Section: Discussionmentioning

confidence: 99%

A Cyclooxygenase-2 Inhibitor Impairs Ligament Healing in the Rat

2001

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Celecoxib was the first of a new class of nonsteroidal antiinflammatory drugs, the cyclooxygenase-2 (COX-2) specific inhibitors, marketed as having the same antiinflammatory efficacy as other nonsteroidal antiinflammatory drugs without their increased risk of gastrointestinal ulceration. Among the widest uses of nonsteroidal antiinflammatory drugs is in the treatment of acute soft tissue injuries. Although the benefits of celecoxib have been shown when used for rheumatoid arthritis and osteoarthritis, we are unaware of any studies concerning its effect on soft tissues. We used the surgically incised medial collateral ligament of male Sprague-Dawley rats as an experimental model for acute ligament injuries to investigate the effects of celecoxib on ligament healing. Fifty rats underwent surgical transection of the right medial collateral ligament. Postoperatively, half were given celecoxib for the first 6 days of recovery, the other half were not. The animals were sacrificed 14 days after the operation, and both the injured and uninjured medial collateral ligaments were mechanically tested to failure in tension. Celecoxib-treated/injured ligaments were found to have a 32% lower load to failure than untreated/injured ligaments. The results of this study do not support use of cyclooxygenase-2 specific inhibitors in the treatment of ligament injuries.

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Section: Discussionmentioning

confidence: 99%

A Cyclooxygenase-2 Inhibitor Impairs Ligament Healing in the Rat

2001

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“…However, by the seventh treatment day, the only statistically significant differences were pain on palpation and muscle force. 26 Not all studies have favored the use of NSAIDs for soft tissue injuries. A small study of 30 soccer players with various sprains and strains compared 50 mg of indomethacin 3 times daily to a placebo.…”

Section: Management Of Acute Soft Tissue Injuriesmentioning

confidence: 99%

Management of Acute Soft Tissue Injuries

McGriff-Lee

2003

Journal of Pharmacy Practice

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Participation in sports-related activities increases the risk for acute injury to soft tissues. In adults, the sites most often affected include the ankle, knee, and wrist joint structures, along with the muscles of the back and extremities. The subsequent inflammatory response to tissue damage results in pain and swelling, which limits mobility. A thorough patient assessment is required for accurate diagnosis and provides a guide for appropriate treatment. Initial management is based on the principles of basic first aid: rest, ice, compression, and elevation. Pharmacological therapy can also be used to achieve pain relief and improve mobility. There are few well-controlled studies addressing the pharmacotherapy of acute soft tissue injury, but clinical experience with nonsteroidal anti-inflammatory drugs is extensive. Both traditional and nontraditional therapeutic approaches are discussed.

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“…8 It is also often used to relieve the migraine symptoms, 9 menstrual pain 10 or pain related to acute injuries. 11 Unfortunately, after oral administration of NPX many more or less severe side-effects are observed. The most frequent are those related to the gastrointestinal tract (GIT) and include stomach pain, dyspepsia, bleeding, ulceration, and vomiting.…”

Section: Introductionmentioning

confidence: 99%

Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior

et al. 2018

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Aims After oral administration, naproxen generates several side-effects related to stomach malfunction. Undoubtedly, the enteric dosage forms with naproxen can be considered as safer. Moreover, since it has been evidenced that development and growth of colorectal cancer is related to the presence of cyclooxygenase, naproxen is investigated in terms of the tumor prevention. The aim of the present work was to formulate and evaluate the properties of novel naproxen-loaded macrobeads, made on the basis of low-acyl gellan gum and its blends with carrageenans, guar gum, cellulose sulfate, and dextran sulfates. Method Seven formulations were prepared by ionotropic gelation. The morphology of the dried beads was evaluated by scanning electron microscopy. The next step focused on Raman spectroscopy and thermal analysis of naproxen, polymers, and the beads. Next, the swelling behavior was examined in three acceptor fluids at pH = 1.2; 4.5, and 7.4. The beads were evaluated regarding naproxen content and encapsulation efficiency. The last stage of the work concerned the drug release studies. Results Addition of any other polysaccharide than gellan resulted in flattening of the beads upon drying. Differential scanning calorimetry confirmed the crystalline form of naproxen. Raman spectra showed that no apparent interactions occurred. In the acidic environment, all the beads revealed the tendency to absorb water. The beads swelled to the greatest extent at pH = 4.5. Naproxen was released from the beads at a varied rate. At pH = 7.4, the most prolonged release was observed for the beads containing carrageenans. Conclusions We have proved that blending of gellan with various polysaccharides can change the pH-dependent properties of the beads loaded with naproxen. We believe that the information enclosed in the paper will be of particular importance regarding the development and characteristics of novel oral dosage forms based on natural polymers.

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Piroxicam and naproxen in acute sports injuries

Cited by 18 publications

References 2 publications

A Cyclooxygenase-2 Inhibitor Impairs Ligament Healing in the Rat

A Cyclooxygenase-2 Inhibitor Impairs Ligament Healing in the Rat

Management of Acute Soft Tissue Injuries

Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior

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