Piroxicam quantitation in human plasma by high-performance liquid chromatography with on- and off-line solid-phase extraction

Simultaneous determination of piroxicam, meloxicam and tenoxicam in human plasma by liquid chromatography with tandem mass spectrometry

“…Since the transdermal delivery avoids the gastrointestinal side effect and first-pass effect, many studies have been carried out in order to develop the percutaneous preparations of NSAIDs, including piroxicam and tenoxicam [1][2][3][4][5][6] number of high performance liquid chromatography (HPLC) methods with UV detection [7][8][9][10][11][12][13][14][15][16], amperometric detection [17] and tandem mass spectrometry (LC-MS/MS) [16,[18][19][20] were reported for the determination of piroxicam, meloxicam or tenoxicam in biological fluids; however, most of those methods presented insufficient sensitivity (limit of detection; 0.72-50 ng/ml), the use of large biological fluid volumes (0.25-1 ml plasma or urine) or chromatographic interferences. There was no LC-MS/MS method reported for the simultaneous determination of meloxicam, piroxicam and tenoxicam in biological samples.…”

Carbon ceramic electrode incorporated with zeolite ZSM-5 for determination of Piroxicam

“…Other side effects such as headache, dizziness, skin rashes, palpitations, edema, and tinnitus are less important and infrequent [29]. Several methods have been proposed involving either spectroscopic or chromatographic techniques for the determination of Piroxicam in pharmaceuticals and biological fluids [30][31][32][33]. However, most of those methods presented insufficient sensitivity owing to the use of large biological fluid volumes or chromatographic interferences.…”

Determination of piroxicam in pharmaceutical formulations and urine samples using europium-sensitized luminescence

“…Different methods have been employed for the determination of PX in pharmaceutical formulations and biological fluids. These include chromatography [3,4], spectrophotometry [5][6][7], voltammetry and native fluorescence [8,9]. The methods based on the native fluorescence of these compounds are not always sensitive and indirect methods involving complexation of the drug with cycodextrin [10,11] or lanthanide ions [12] have been investigated.…”