Pistacia lentiscus L. leaves extract and its major phenolic compounds reverse aluminium-induced neurotoxicity in mice

Azib, Lila; Debbache-Benaida, Nadjet; Costa, Grégory Da; Atmani-Kilani, Dina; Saidene, Naima; Ayouni, Karima; Richard, Tristan; Atmani, Djebbar

doi:10.1016/j.indcrop.2019.05.062

Cited by 39 publications

(29 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“….Previous studies reported that the plant leaves extracts constitute a rich source of natural polyphenols compounds with a high concentration of flavonoids and phenolics acids [15][16][17][18] and validated the virtues of the plant as antioxidant [15], anti diabetic [16]anti-inflammatory and anti-tumoral [17].In recent published study, we reported that leaves extracts of P.lentiscus L have a strong effect in aluminum induced neurotoxicity in mice [18].…”

Section: Introductionmentioning

confidence: 60%

“…Previous studies showed the presence of flavonoids, phenolic acids, and tannins in the leaves of P. lentiscus exhibiting anti-proliferative activity against solid cancers (breast, melanoma and colon) [17,18]. In order to evaluate the anti-proliferative activity of methanolic, ethanolic and acetonic leaves extracts of P. lentiscus in ovarian cancer cells, Cells viability assays were performed using two commercially available cell lines A2780 and SKOV3.…”

Section: Methanolic Extracts Of P Lentiscus (Mepl) Exhibit Cytotoxic Effect In Ovarian Cancer Cells: A2780 and Skov3mentioning

confidence: 99%

“…Super Natural II is a freely available web-based database of natural products (NPs) (http://bioinformatics.charite.de/supernatural) [24].It contains information on over 300.000 natural compounds regarding their chemical structures, and their known biological activities including known mechanism of action (MoA) and associated pathway information. We previously have been shown by HPLC and RMN that MEPL contains flavonoids like catechin, quercetin, myricetin, kaempferol and luteolin [18,25].Based on the database of Super Natural II, these flavonoids are natural active substances with anti-inflammatory properties.…”

Section: Identification Of Mechanism Of Action Using the Super Natural II Databasementioning

confidence: 99%

See 2 more Smart Citations

Pretreatment with methanolic extract of Pistacia lentiscus L. increases sensitivity to DNA damaging drugs in primary high-grade serous ovarian cancer cells

Charid

Kessler

Darb‐Esfahani

et al. 2020

European Journal of Integrative Medicine

Self Cite

View full text Add to dashboard Cite

Introduction: Ovarian cancer remains the most lethal gynecologic cancer in women. Despite achievements in surgical and systemic therapy, most patients develop platinum resistance. Thus, new strategies to increase or reverse the platinum sensitivity in ovarian cancer patients are urgently needed. In this study, we aimed to investigate the anti-cancer effect of the leaves of Pistacia lentiscus L medicinal plants used in Algerian traditional medicine on ovarian cancer cells in vitro.Methods: Four newly established primary cell lines derived from ascites of patients with highgrade serous and clear cell ovarian cancer were used to test the anti-cancer effect of the leaves of Pistacia lentiscus L. An experimental study was performed to study the therapeutic effects of the plant leaves substances in patient derived models. The anti-proliferative activity of ethanolic, acetonic and methanolic plant leaves extracts was measured by cell viability assays, and the apoptotic effect assessed using flow cytometry analysis. The impact on constitutive active oncogenic pathways and cytokine release in cell culture supernatant were monitored by Western blotting and ELISA, respectively.Results: Sequencing analysis confirmed the presence of mutations in several genes, such as TP53, RB1, PIK3C, which are commonly mutated in high-grade serous ovarian cancer. Obtained results indicated a cytotoxic effect of the methanolic extract of P.lentiscus L (MEPL) on primary cell line cultures, inhibiting PI3K/AKT and MAPK/ERK signaling pathways, and decreasing the release of IL6 and VEGF by the malignant cells. Moreover, treatment with MEPL enhanced the sensitivity to platinum-based chemotherapy in our primary cell lines of patients. Conclusion:Methanolic extract of P. lentiscus L might be a promising candidate for novel therapeutic approaches in combination with classic chemotherapy for patients with high-grade serous ovarian cancer.

show abstract

Section: Introductionmentioning

confidence: 60%

Section: Methanolic Extracts Of P Lentiscus (Mepl) Exhibit Cytotoxic Effect In Ovarian Cancer Cells: A2780 and Skov3mentioning

confidence: 99%

Section: Identification Of Mechanism Of Action Using the Super Natural II Databasementioning

confidence: 99%

See 1 more Smart Citation

Pretreatment with methanolic extract of Pistacia lentiscus L. increases sensitivity to DNA damaging drugs in primary high-grade serous ovarian cancer cells

Charid

Kessler

Darb‐Esfahani

et al. 2020

European Journal of Integrative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…A high proportion of polyunsaturated fatty acids (PUFAs) content, low levels of natural antioxidants, and high oxygen consumption are characteristic of brain membrane. These characteristics are especially sensitive to peroxide and ROS (Azib et al, 2019). The peroxidation of the brain membrane is one of the most important mechanisms.…”

Section: Methods Resultsmentioning

confidence: 99%

Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster)

Irnidayanti

Aprilyanti

2021

Berkala Penelitian Hayati

View full text Add to dashboard Cite

The toxicity of metal to living organisms, including human beings, was discovered a long time ago. In the present time, aluminum exposure is widely used for wrapping food to keep it taste and smell. However it will affect to human health security, specially the brain. This study aimed to investigate the changes of histological Structure on the cerebral cortex caused by aluminum chloride. The mice were injected intraperitoneally with AlCl3 200 mg per kg body weight, once every 3 days, totalizing 10 administrations. Control only was administration distilled water. Histological observations were carried out using the paraffin method. The results of this study show that aluminum chloride cause disorganization of the laminated cerebral cortex, vacuolization, karyolysis, congestion, and hemorrhage. The mice of one and two-months of age group were more susceptible to aluminum chloride than the mice of the three-months of age group. This research can apply for an assessment of the exposure risk to heavy metal. Increasing Al contamination can occur naturally or by anthropogenic activities. The accumulation of the heavy metal in the organism can occur by biomagnification, by which heavy metal is passed from one trophic level to the next within a food web. Therefore communities that live in urban areas potentially exposed to metals aluminum and should be more concerned related to understanding health risks. Further studies are needed to examine the

show abstract

“…The significant inhibition of acetylcholinesterase and related enzymes is responsible for the neuroprotective effect of P. terebinthus [80]. The leaf extract and its major phenolic compounds of P. lenticus reversed the aluminum-induced neurotoxic effect in mice [81]. The toxic effect of mercury on brain was regulated by the P. atlantica indicating the neuroprotective role [82].…”

Section: Neuroprotective Effectmentioning

confidence: 99%

Pharmacological Investigation of Genus Pistacia

Rauf¹,

Al-Awthan²,

Muhammad³

et al. 2022

Natural Medicinal Plants

View full text Add to dashboard Cite

Several plants in the genus Pistacia are used in the treatment of various pathogenic and non-pathogenic disorders. Especially important are the major species belonging to this genus such as Pistacia lentiscus, Pistacia atlantica, Pistacia vera, Pistacia terebinthus, and Pistacia khinjuk, among others; these have been reported for their potential benefits both in medical and commercial purposes. In addition, members of this genus exhibit numerous ethnomedicinal uses, such as analgesic, anti-inflammatory, anticancer, antimicrobial, antihypertension, antihyperlipidemic, antiviral, and antiasthma. In light of these potential uses, the present chapter aimed to collect and summarize the literature about all of this medicinal information. Accordingly, this chapter focuses on the pharmacological uses and benefits of the genus Pistacia, especially those related to health issues.

show abstract

Pistacia lentiscus L. leaves extract and its major phenolic compounds reverse aluminium-induced neurotoxicity in mice

Cited by 39 publications

References 49 publications

Pretreatment with methanolic extract of Pistacia lentiscus L. increases sensitivity to DNA damaging drugs in primary high-grade serous ovarian cancer cells

Pretreatment with methanolic extract of Pistacia lentiscus L. increases sensitivity to DNA damaging drugs in primary high-grade serous ovarian cancer cells

Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster)

Pharmacological Investigation of Genus Pistacia

Contact Info

Product

Resources

About