Pistagremic Acid, a Novel Antimicrobial and Antioxidant Isolated from Pistacia integerrima

Uddin, Ghias; Latif, Abdul; Muhammad, Naveed

doi:10.1007/s10600-014-0875-2

Cited by 17 publications

(11 citation statements)

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“…It has also been reported to possess CNS depressant activity (Ansari., 1994a). The aim of current study was to isolated (PA) from Pistacia integerrima (Rauf et al, 2014a;Rauf et al, 2014b) and screen for multidrug resistance-reversal effects. …”

Section: Introductionmentioning

confidence: 99%

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Uddin¹,

Raza²,

Ahmad³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp.

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Section: Introductionmentioning

confidence: 99%

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Uddin¹,

Raza²,

Ahmad³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Structures of triterpenes are shown in Figure 6. -7-(4,4,10,13,14-pentamethyl-3-2,3,4,5,6,7,10,11,12,13,14,15,16, 17-tetradecahydro-1H-cyclopenta[a] phenanthr-en-17-yl)-oct-3-enoic acid Leishmanicidal, anticancer, antimicrobial, antioxidant, β-secretase inhibition, α-glucosidase inhibition (Uddin et al, 2011;Rauf, Uddin, Latif, & Muhammad, 2014;Rauf, A et al, 2015;Uddin et al, 2012b) Pistacienoic acid A - (Chauhan, Singh, & Agarwal, 2002) Pistacienoic acid B -…”

Section: Phenolicsmentioning

confidence: 99%

“…Pistagremic acid was isolated from the methanolic extract of the dried galls and subsequently identified using X‐ray crystallography (Uddin et al, 2011). Pistagremic acid showed significant pharmacological potential in various studies such as leishmanicidal, (Uddin et al, 2011; Uddin et al, 2012) anticancer, antimicrobial, (Rauf et al, 2014) β‐secretase inhibition (Rauf et al, 2015) and α‐glucosidase inhibition activities (Uddin, Rauf, Arfan, et al, 2012). Its structure is shown in Figure 2.…”

Section: Phytochemistrymentioning

confidence: 99%

“…This suggests the difference in nature of antimicrobial active constituents present in different fractions of P. integerrima bark extract (Rahman et al, 2011). On the other hand, 0.2 ml of pistagremic acid showed less zones of inhibition toward Straptodirimu, Kelbsiella pneumonia and B. stearothermophilus , that is, 20, 15 and 14 mm, respectively (Rauf et al, 2014). As essential oils P. integerrima showed a powerful antibacterial potential compared with its other compounds, it is suggested due to presence of essential oils.…”

Section: Pharmacology and Ethnopharmacologymentioning

confidence: 99%

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Ethnobotany, ethnopharmacology, phytochemistry, biological activities and toxicity of Pistacia chinensis subsp. integerrima: A comprehensive review

Almubayedh

Ahmad

Naqvi

et al. 2020

Phytotherapy Research

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Pistacia chinensis subsp. integerrima (J. L. Stewart ex Brandis) Rech. F. is a valuable medicinal plant used in south Asian communities for the treatment of asthma, diarrhea, diabetes, liver diseases, fever, pain and inflammation. This review critically evaluates the available information on P. integerrima's ethnobotany, ethnopharmacology, phytochemistry, pharmacology and toxicology. Electronic databases such as Google Scholar, PubMed, Springer Link, and so forth, books and theses were used to find relevant information about P. integerrima using keywords such as "Pistacia integerrima," "P. integerrima," "Ethnopharmacology," "Phytochemistry," "Traditional uses". A number of in vitro and in vivo pharmacological activities have been reported; however, the most promising and attractive activity observed was its role in Alzheimer, diabetes, convulsions, cancer, asthma, diabetes, diarrhea and as an immunomodulatory, analgesic and antiinflammatory. In addition, Pistagremic acid exerted anti-Alzheimer's activity based on a hitherto unknown mechanism through interference with the amyloidogenic pathway. Most of the pharmacological activities were linked with traditional uses. A range of compounds have been reported from P. integerrima extracts including triterpenes, volatile oils, flavonoids, fatty acids, phenolic, phytosterols, tannins and oligosaccharides as well as unknown triterpenes and flavonoids. Pistagremic acid, a novel triterpene, was attributed to most of the activities. in vivo toxicological studies in animal suggested a toxic dose of 1,500 mg kg −1 , for its methanolic extract. All reported pharmacological activities were carried out in vitro and a gap in research, that is, preclinical and clinical investigation exists. Its outstanding activity as an antiglycating agent is the most promising and a so far unique activity and needs further evaluation. In-depth research and clinical trials on human subjects in order to investigate P. integerrima pharmacological activity, clinical efficacy and safety are crucial next steps.

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“…and Bacillus stearothermophilus [34]. The fatty acids esters such as cyclopentane-tridecanoic acid, methyl ester, tartronic acid n-Hexadecanoic acid (p-ethoxyphenyl), diethyl ester, 7,10-octadecadenoic acid, methyl ester, heptadecanoic acid, 16-methyl methyl ester, and 9-Octadecenoic acid [Z]-, 2-hydroxyl-1-[hydroxymethyl], ethyl ester were isolated from petroleum ether extract of dried fruiting bodies of Pleurotus eous against Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumonia [35].…”

Section: Volumementioning

confidence: 99%

Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the <i>Psydrax dicoccos </i>(Gaertn) Teys. & Binn. Rubiaceae Family

Umaiyambigai

Saravanakumar

Raj

2017

IJPPE

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Abstract. The present study was aimed to antifungal activity and phytoconstituents of leaves from the Psydrax dicoccos Gaertn. The antifungal activity of methanol extract from the P. dicoccos against Candida albicans, C. krusei, C. guilliermondii, C. parapsilosis, C. tropicalis, C. glabrata, four dermatophytes viz., Trichophyton rubrum, T. mentagrophytes, Microsporum gypseum and Epidermophyton flocossum. The methanol extract of the leaves were subjected to Fourier transform infrared spectroscopy (FT-IR) and Gas Chromatography-Mass Spectroscopic (GC-MS) analysis. The mean zones of inhibition produced by the tested extract in disc diffusion assays against fungal strains were ranged from 7.3 to 15.5 mm. The MIC values were between 125 and 500 µg/ml while, the MFC values were between 250 and 1000 µg/ml. The highest mean zones of inhibition (15.5± 0.6 mm) was observed with methanol extract of P. dicoccos against C. albicans. The GC-MS analysis of P. dicoccos leaves showed the presence of cinnamic acid, 2H-1-Benzopyran-2-one,5,7-dimethoxy,(Z)6,(Z)9-Pentadecadien-1-ol, Benzofuran and n-Hexadecanoic acid as major compounds. Finally it can be concluded that the antifungal activity may be present in cinnamic acid, 2H-1-Benzopyran-2-one, 5, 7-, (Z) 6,(Z)9-Pentadecadien-1-ol, n-Hexadecanoic acid from the methanol extract from the P. dicoccos is highly valuable in medicinal usage and have fewer side effects.

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Pistagremic Acid, a Novel Antimicrobial and Antioxidant Isolated from Pistacia integerrima

Cited by 17 publications

References 4 publications

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Ethnobotany, ethnopharmacology, phytochemistry, biological activities and toxicity of Pistacia chinensis subsp. integerrima: A comprehensive review

Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the <i>Psydrax dicoccos </i>(Gaertn) Teys. & Binn. Rubiaceae Family

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Pistagremic Acid, a Novel Antimicrobial and Antioxidant Isolated from Pistacia integerrima

Cited by 17 publications

References 4 publications

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Ethnobotany, ethnopharmacology, phytochemistry, biological activities and toxicity of Pistacia chinensis subsp. integerrima: A comprehensive review

Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the <i>Psydrax dicoccos </i>(Gaertn) Teys. &amp; Binn. Rubiaceae Family

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Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the <i>Psydrax dicoccos </i>(Gaertn) Teys. & Binn. Rubiaceae Family