Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Lindér, Jan; Doorn, Jan van

doi:10.1044/1092-4388(2012/11-0333)

Cited by 18 publications

(13 citation statements)

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“…1 for an overview), has been proposed as a promising alternative target for DBS treatment for motor symptoms of PD, with one study suggesting greater improvement in gross motor symptoms with cZi stimulation than with stimulation of the STN (21). Furthermore, we have not found any positive effect in terms of improving the monopitch quality in speech due to cZi-DBS (10), and voice intensity may show a small reduction during cZi stimulation (9). Furthermore, we have not found any positive effect in terms of improving the monopitch quality in speech due to cZi-DBS (10), and voice intensity may show a small reduction during cZi stimulation (9).…”

Section: Introductionmentioning

confidence: 67%

“…However, the results have been more mixed in terms of speech. Affection of speech is common in the movement disorders for which DBS might be beneficial, but DBS is known to cause a variety of speech-related side effects in several neurological conditions (e.g., [6][7][8][9][10][11]. Specifically for STN-DBS treatment for patients with PD, while some studies have reported no effect (5,12) or only short-term positive effects (13,14), a majority of studies have reported a reduction in overall speech quality or intelligibility due to stimulation (e.g., [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Word-level intelligibility after caudal zona incerta stimulation for Parkinson's disease

et al. 2013

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Section: Introductionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Word-level intelligibility after caudal zona incerta stimulation for Parkinson's disease

et al. 2013

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“…Even though there are diverse pharmacological and surgical treatment options available to alleviate motor symptoms in PD, their effect on the dysarthria is limited and variable (7)(8)(9)(10)(11)(12)(13)(14). The leading treatment option for speech and voice symptoms in PD today is the LSVT LOUD V R Lee Silverman Voice Treatment (LSVT Global, Tucson, AZ) (15).…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of Lee Silverman Voice Treatment on daily voice use in Parkinson’s disease as measured with a portable voice accumulator

Gustafsson

Södersten

Ternström

et al. 2018

Logopedics Phoniatrics Vocology

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This study examines the effects of an intensive voice treatment focusing on increasing voice intensity, LSVT LOUD Lee Silverman Voice Treatment, on voice use in daily life in a participant with Parkinson's disease, using a portable voice accumulator, the VoxLog. A secondary aim was to compare voice use between the participant and a matched healthy control. Participants were an individual with Parkinson's disease and his healthy monozygotic twin. Voice use was registered with the VoxLog during 9 weeks for the individual with Parkinson's disease and 2 weeks for the control. This included baseline registrations for both participants, 4 weeks during LSVT LOUD for the individual with Parkinson's disease and 1 week after treatment for both participants. For the participant with Parkinson's disease, follow-up registrations at 3, 6, and 12 months post-treatment were made. The individual with Parkinson's disease increased voice intensity during registrations in daily life with 4.1 dB post-treatment and 1.4 dB at 1-year follow-up compared to before treatment. When monitored during laboratory recordings an increase of 5.6 dB was seen post-treatment and 3.8 dB at 1-year follow-up. Changes in voice intensity were interpreted as a treatment effect as no significant correlations between changes in voice intensity and background noise were found for the individual with Parkinson's disease. The increase in voice intensity in a laboratory setting was comparable to findings previously reported following LSVT LOUD. The increase registered using ambulatory monitoring in daily life was lower but still reflecting a clinically relevant change.

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“…It is associated with minimal morbidity and is effective also for PD patients that have ceased to respond L-dopa (Levodopa) treatment (Breit et al 2004). DBS has generally been found to improve gross motor functioning as well as patients' quality of life (Daniels et al 2011), but has also been shown a potential for causing a variety of speech-related side effects in several neurological conditions (e.g., Blomstedt et al 2011b;Karlsson et al 2011Karlsson et al , 2013Karlsson et al , 2014Lundgren et al 2011;Fytagoridis et al 2012Fytagoridis et al , 2013. For patients with PD, traditional targets include the STN (subthalamic nucleus) (Benabid 2003) and the GPi (globus pallidus pars interna) (Rodriguez-Oroz et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Speech intelligibility in Parkinson's disease patients with zona incerta deep brain stimulation

et al. 2015

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ObjectivesTo investigate the effects of l‐dopa (Levodopa) and cZi‐DBS (deep brain stimulation in caudal zona incerta) on spontaneous speech intelligibility in patients with PD (Parkinson's disease).Materials and MethodsSpontaneous utterances were extracted from anechoic recordings from 11 patients with PD preoperatively (off and on l‐dopa medication) and 6 and 12 months post bilateral cZi‐DBS operation (off and on stimulation, with simultaneous l‐dopa medication). Background noise with an amplitude corresponding to a clinical setting was added to the recordings. Intelligibility was assessed through a transcription task performed by 41 listeners in a randomized and blinded procedure.ResultsA group‐level worsening in spontaneous speech intelligibility was observed on cZi stimulation compared to off 6 months postoperatively (8 adverse, 1 positive, 2 no change). Twelve months postoperatively, adverse effects of cZi‐DBS were not frequently observed (2 positive, 3 adverse, 6 no change). l‐dopa administered preoperatively as part of the evaluation for DBS operation provided the overall best treatment outcome (1 adverse, 4 positive, 6 no change).Conclusions cZi‐DBS was shown to have smaller negative effects when evaluated from spontaneous speech compared to speech effects reported previously. The previously reported reduction in word‐level intelligibility 12 months postoperatively was not transferred to spontaneous speech for most patients. Reduced intelligibility due to cZi stimulation was much more prominent 6 months postoperatively than at 12 months.

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Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

Cited by 18 publications

References 54 publications

Word-level intelligibility after caudal zona incerta stimulation for Parkinson's disease

Word-level intelligibility after caudal zona incerta stimulation for Parkinson's disease

Long-term effects of Lee Silverman Voice Treatment on daily voice use in Parkinson’s disease as measured with a portable voice accumulator

Speech intelligibility in Parkinson's disease patients with zona incerta deep brain stimulation

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