Pitfalls in whole body MRI with diffusion weighted imaging performed on patients with lymphoma: What radiologists should know

Albano, Domenico; Grutta, Ludovico La; Grassedonio, Emanuele; Patti, Caterina; Lagalla, Roberto; Midiri, Massimo; Gallucci, M.

doi:10.1016/j.mri.2016.04.023

Cited by 49 publications

(34 citation statements)

References 50 publications

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“…Further, the mADC values of bone marrow of vertebral bodies adjacent to the tumor may be affected by hidden micrometastases or diffuse malignant infiltration: this could be not enough to visibly change marrow signal intensity but sufficient to alter the diffusivity of water molecules, thereby modifying the mADC values . Last, marrow cellularity is influenced by gender, inflammatory conditions, metabolic factors, and by marrow activation seen in some diseases such as lymphoma . At any rate, a nonnegligible overlap was seen among TB of the three categories, thus probably making this parameter also not helpful in a specific patient.…”

Section: Discussionmentioning

confidence: 99%

Solid bone tumors of the spine: Diagnostic performance of apparent diffusion coefficient measured using diffusion‐weighted MRI using histology as a reference standard

Pozzi

Albano

Messina

et al. 2017

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

Solid bone tumors of the spine: Diagnostic performance of apparent diffusion coefficient measured using diffusion‐weighted MRI using histology as a reference standard

Pozzi

Albano

Messina

et al. 2017

Magnetic Resonance Imaging

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“…WB-MRI enables avoiding radiation exposure and intravenous contrast agent administration, allowing the evaluation of all potential lymphomatous sites through morphological and functional sequences ( Figs. 1 and 2) [28]. Indeed, while CT provides only morphological information regarding nodal and extra-nodal locations of disease, diffusion-weighted imaging allows the random motion of water molecules in biological structures to be investigated and allows easy identification of hypercellular tissues like lymphoma [29].…”

Section: Imaging Monitoring and Wwmentioning

confidence: 99%

Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

et al. 2017

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The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by 'indolent' clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and CT. A major concern is radiation exposure due to regularly monitoring by conventional imaging procedures. Several studies have demonstrated the reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging. WB-MRI could be useful for active surveillance in iNHLs providing the suspect of disease progression that can be then confirmed by additional diagnostic procedures, including 18F-FDG-PET/CT. The directive 2013/59 by the European Union claims that if a radiation-free imaging technique allows obtaining the same diagnostic results, it should be invariably used.In this setting, WB-MRI may be considered a reasonable option in i-NHLs under WW, replacing imaging modalities that cause exposure to ionising radiations. This will help to reduce the cancer risk in i-NHL patients for whom chemo-/radiotherapy remain the usual treatment options following the usually long WW phase. The scientific community should raise the awareness of the risk of ionising radiations in i-NHLs and the emphasise the need for establishing the proper place of WB-MRI in lymphoma imaging. Key Points• Watchful waiting is a reasonable option in patients with indolent non-Hodgkin lymphomas.• Imaging is crucial to monitor patients with indolent nonHodgkin lymphomas.• CT and 18 F-FDG-PET/CT are commonly used, implying a substantial radiation exposure.• WB-MRI is highly reliable in lymphoma staging.• WB-MRI may be considered to monitor indolent nonHodgkin lymphomas under watchful waiting.

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“…The novelty of this case report is also that a rare caecal tumor was detected through unenhanced WB-MRI, which is a well-established technique for lymphoma staging (21)(22)(23) and response assessment to treatments (24,25) and that was applied in the follow-up of our patient. WB-MRI is an imaging procedure that enables a whole body examination with high potential for application in oncologic patients using diffusion-weighted imaging (26)(27)(28)(29). It also avoids radiation exposure in patients with high cancer risk like those with lymphoma and enables the detection of relevant incidental findings during the oncologic follow-up (30).…”

Section: Discussionmentioning

confidence: 99%

Caecal leiomyoma detected by whole-body MRI in a patient with Hodgkin lymphoma: first case report

Albano

Sinagra²,

Patti³

et al. 2017

GHIR

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Pitfalls in whole body MRI with diffusion weighted imaging performed on patients with lymphoma: What radiologists should know

Cited by 49 publications

References 50 publications

Solid bone tumors of the spine: Diagnostic performance of apparent diffusion coefficient measured using diffusion‐weighted MRI using histology as a reference standard

Solid bone tumors of the spine: Diagnostic performance of apparent diffusion coefficient measured using diffusion‐weighted MRI using histology as a reference standard

Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

Caecal leiomyoma detected by whole-body MRI in a patient with Hodgkin lymphoma: first case report

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