Pitfalls with anti-neutrophil cytoplasmic antibodies (ANCA)

Clerck, Luc S. De; Offel, J.F. Van; Smolders, W. A.; Empsten, F. A.; Bridts, Chris H.; Bourgeois, N; Marck, E. Van; Timmermans, U.; Stevens, W.J.

doi:10.1007/bf02032106

Cited by 27 publications

(11 citation statements)

References 13 publications

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“…Invasive amoebiasis is the only infection that has been reported to be associated with PR3-ANCA to date (143). These and other reports of autoantibodies causing cytoplasmic fluorescence on ethanol-fixed neutrophils from patients with infection (144)(145)(146) show the importance of excluding infectious processes before initiating immunosuppressive therapy.…”

Section: Diseases Associated With Anca and Their Target Antigensmentioning

confidence: 95%

Antineutrophil cytoplasmic antibodies

Hoffman

Specks

1998

Arthritis & Rheumatism

378

148

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Section: Diseases Associated With Anca and Their Target Antigensmentioning

confidence: 95%

Antineutrophil cytoplasmic antibodies

Hoffman

Specks

1998

Arthritis & Rheumatism

378

148

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“…These cases suggest that chronic suppurative pulmonary infection induces systemic angitis 15 . There is also a reported case of lung tuberculosis combined with ANCA‐positive vasculitis 16 . In that patient, although open lung biopsy showed that the pulmonary infarction was due to angitis, the sputum cultures became positive for Mycobacterium tuberculosis .…”

Section: Discussionmentioning

confidence: 95%

A case of pulmonary arteritis with stenosis of the main pulmonary arteries with positive myeloperoxidase‐antineutrophil cytoplasmic autoantibodies

Nakayama¹,

Uchida²,

Sim³

et al. 2000

Respirology

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A 53-year-old woman was referred to our hospital with the main symptoms of productive cough, fever and exertional dyspnoea. Chest X-ray revealed enlargement of the left hilar shadow and cavitary infiltration in the right upper lobe. 99mTechnetium-macroaggregated albumin (99mTc-MAA) perfusion scintigram showed complete hypoperfusion through the entire right lung. A pulmonary angiogram revealed stenotic lesions in the right and left main pulmonary arteries. Right cardiac catheterization showed an elevated right ventricular systolic pressure. There was no evidence of systemic arterial lesions nor vasculitis. The patient was positive for myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibodies (ANCA) (168 EU). The Mycobacterium avium complex sputum culture was positive. The pulmonary stenotic lesions were surgically resected. The resected pulmonary arterial lesions were pathologically diagnosed as non-specific vasculitis. The cavitary lesion disappeared 6 months after the surgery. Two years after the surgery, although the MPO-ANCA level had decreased to 12 EU, stenosis of the pulmonary arteries reappeared. It is suggested that the patient became positive for MPO-ANCA in association with the Mycobacterium avium complex infection, and that the presence of MPO-ANCA may not be related to the development of pulmonary stenosis of the main pulmonary arteries.

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“…Several reports have described positive cANCA testing in patients with infections when immunosuppressive therapy could have been detrimental [11,12,13].…”

Section: Discussionmentioning

confidence: 97%

Influenza A-associated bronchiolitis obliterans organizing pneumonia mimicking Wegener's granulomatosis

Staud

Ramos

2001

Rheumatol Int

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We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic antibodies (cANCA). The results of an open-lung biopsy were consistent with BOOP. Although BOOP has previously been described as one of the pulmonary manifestations of WG, other more specific histologic features of WG such as capillaritis or necrotizing vasculitis were lacking. Because influenza A virus was cultured from the patient's lung tissue, final assessment of the illness focused on this as the etiologic agent triggering the pulmonary syndrome. The presence of ANCA was considered to be nonspecific. The patient's condition improved with appropriate therapy for BOOP.

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Pitfalls with anti-neutrophil cytoplasmic antibodies (ANCA)

Cited by 27 publications

References 13 publications

Antineutrophil cytoplasmic antibodies

Antineutrophil cytoplasmic antibodies

A case of pulmonary arteritis with stenosis of the main pulmonary arteries with positive myeloperoxidase‐antineutrophil cytoplasmic autoantibodies

Influenza A-associated bronchiolitis obliterans organizing pneumonia mimicking Wegener's granulomatosis

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