Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

Kotańska, Magdalena; Mika, Kamil; Sałaciak, Kinga; Wheeler, Lee; Sapa, Jacek; Kieć‐Kononowicz, Katarzyna; Pytka, Karolina

doi:10.1016/j.pbb.2020.172974

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…The great majority of animal models of depression produce a depressive‐like phenotype either by exposure to stressors or by direct administration of CORT 27–29 . We have created an animal model of depression using CORT that has been shown to be effective in previous studies 30 . Glucocorticoid treatment for 7 days has been shown to cause cognitive deficits in mice but not depressive‐like behaviour.…”

Section: Discussionmentioning

confidence: 99%

“…[27][28][29] We have created an animal model of depression using CORT that has been shown to be effective in previous studies. 30 Glucocorticoid treatment for 7 days has been shown to cause cognitive deficits in mice but not depressive-like behaviour. However, treatment for over 14 days has been shown to cause all of these behavioural deficits, including cognitive deficits and depressive-like behaviour.…”

Section: The Effect Of Cur On Mitochondrial Distribution and Mitophag...mentioning

confidence: 99%

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Curcumin relieves corticosterone‐induced behaviour deficits via PGC‐1α‐mediated mitochondrial biogenesis and mitophagy

Zhang

Guo

et al. 2022

Clinical and Translational Dis

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Curcumin (CUR), an FDA‐approved natural product, has been found to be clinically effective in treating depression. However, the underlying mechanism remains elusive. PGC‐1α is a key factor in regulating mitochondrial health and depression. This study randomly divided C57BL/6 mice or cultured hippocampal neurons into four groups: CON, CORT, CORT + CUR and CORT + CUR + SR18292. The present study demonstrated that CUR was effective in suppressing CORT‐induced depressive‐like behaviour, as well as improving anxiety‐like behaviour and cognitive function. CUR was found to be effective in preventing oxidative stress induced by corticosterone (CORT), as evidenced by the restoration of Nrf2, NQO‐1, HO‐1, GCLC, SOD‐1 and DHE levels in cells. CUR inhibited the CORT‐induced perinuclear accumulation of mitochondria in vitro. Furthermore, CUR promoted mitochondrial biogenesis, potentially reversing the effect of CORT on NRF1, TFAM, PGC‐1α and the relative MT‐CO1/SDH‐A ratio. Lastly, the treatment of CUR normalized the CORT‐hindered mitophagy by upregulating the protein level of NIX, Beclin‐1, PINK1, Parkin and LC3II/LC3I, and enhancing the relative mt‐Keima signal. The protective effect of CUR was entirely negated by SR18292. CUR could regulate oxidative stress, mitochondrial biogenesis and mitophagy via PGC‐1α to achieve an anti‐depressive‐like function. This study would contribute to a greater understanding of how CUR alleviates depressive symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: The Effect Of Cur On Mitochondrial Distribution and Mitophag...mentioning

confidence: 99%

Curcumin relieves corticosterone‐induced behaviour deficits via PGC‐1α‐mediated mitochondrial biogenesis and mitophagy

Zhang

Guo

et al. 2022

Clinical and Translational Dis

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TRPA1 participation in behavioral impairment induced by chronic corticosterone administration

et al. 2022

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CircSYNDIG1 ameliorates stress-induced abnormal behaviors by suppressing miR-344-5p in mice

Wang¹,

Song²,

Du³

et al. 2023

Brain Research Bulletin

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Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

Cited by 5 publications

References 38 publications

Curcumin relieves corticosterone‐induced behaviour deficits via PGC‐1α‐mediated mitochondrial biogenesis and mitophagy

Curcumin relieves corticosterone‐induced behaviour deficits via PGC‐1α‐mediated mitochondrial biogenesis and mitophagy

TRPA1 participation in behavioral impairment induced by chronic corticosterone administration

CircSYNDIG1 ameliorates stress-induced abnormal behaviors by suppressing miR-344-5p in mice

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