Pitot-Rohr-Katheter für die fortlaufende Messung der Koronar- und Nierendurchblutung im Tierexperiment

Hensel, Isabell; Bretschneider, H. J.

doi:10.1007/bf02135205

Cited by 42 publications

(4 citation statements)

References 53 publications

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“…The rate of increase (LV dP/dt) was obtained by differentiating the left ventricular pressure signal using a Statham SP 1400 amplifier and an RC differentiating circuit. Myocardial blood flow (CBF) was measured continuously by the pressure difference technique as described by Hensel and Bretschneider (1970). The reference pressure catheter was inserted into the right external jugular vein; its tip was advanced into the coronary sinus and fixed in position with a fluid-filled cuff.…”

Section: Methodsmentioning

confidence: 99%

Antagonism of Morphine With Naloxone in Dogs: Cardiovascular Effects With Special Reference to the Coronary Circulation

Patschke

Eberlein

Heß

et al. 1977

British Journal of Anaesthesia

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The cardiovascular effects of naloxone 15 microgram/kg following morphine 2.0 mg/kg were studied in closed-chest dogs during light nitrous oxide-halothane anaesthesia. The bolus injection of naloxone caused an increase in heart rate (73%), cardiac output (20%) and mean arterial pressure (20%). Total peripheral resistance was unaffected. LV dP/dt max and LV dP/dt max/IP increased by 25% and 14% respectively, but positive inotropic effects could not be shown when load data, heart rate and the decrease in left ventricular ejection fraction (22%) were taken into consideration. The cardiovascular stimulation resulted in an increase in myocardial oxygen demand (66%) which was met by an increase in coronary blood flow (59%). The data suggest that the antagonism of narcotics with high doses of naloxone may impair the myocardial oxygen supply in patients suffering from coronary insufficiency. It is concluded that naloxone should be titrated for each patient to ensure adequate reversal of respiratory depression and to avoid circulatory stress.

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Section: Methodsmentioning

confidence: 99%

Antagonism of Morphine With Naloxone in Dogs: Cardiovascular Effects With Special Reference to the Coronary Circulation

Patschke

Eberlein

Heß

et al. 1977

British Journal of Anaesthesia

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“…Bretschneider, Hensel, Hellige u. a. haben langjährige Erfahrungen mit Nieren-und Koronardurchblutungsmessungen [4]. Die Blutgäsmassenspektrometrie dient der Inertgaskonzentrationsbestimmung für Organdurchblutungsmessungen und zu Stoffwechselgasregistrierungen.…”

Section: Introductionunclassified

Arterielle und koronarvenöse Blutgasanalysen mit einem Druckdifferenzkatheter - Arterial and Coronary Venous Blood Gas Analysis with a Pressure Difference Catheter

Beste¹

1985

Biomedizinische Technik/Biomedical Engineering

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Schlüsselwörter: Koronardurchblutung, statische und dynamische Drucke Für die parallele arterielle und venöse Blutgasanalyse wurde ein neues Doppel-Quadrupol-Massenspektrometer konstruiert. Die Blutentnahme erfolgt dabei z. B. aus der A. femoralis oder dem Sinus coronarius mit Spezialkathetern. Die Koronardurchblutung wird entweder aus der Druckdifferenz zwischen dem Gesamtdruck und dem statischen Druck oder mit Hilfe verschiedener Inertgaskonzentrationen bestimmt. Mit dem konstruierten Doppelmassenspektrometer wurden auch Aufzeichnungen von kontinuierlichen Massenspektren durchgeführt, so daß Stoffwechseluntersuchungen möglich sind.Key-words: Coronary blood flow, static and dynamic pressures For parallel arterial and venous blood gas analysis, a new double quadrupole mass spectrometer has been designed. The blood is taken, for example, from the femoral artery or the coronary sinus with special catheters. The coronary blood flow was determined either by the difference between the total pressure and the static pressure or, with the aid of various inert gas concentrations. With double mass spectrometer mass spectra were also continously recorded, indicating that metabolic investigations are possible.

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“…. Myocardial blood flow with a differential pressure catheter positioned in the coronary sinus (17). 8.…”

mentioning

confidence: 99%

The DPTI/STTI Ratio as an Estimate of the Myocardial Oxygen Supply/Demand Ratio

Baller¹,

Ensink²,

Sigmund-Duchanova³

et al. 1979

Thorac cardiovasc Surg

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The DPTI/STTI ratio is applied to man, both in health and disease, for estimating the myocardial oxygen supply/ demand ratio. The physiological concept and the divergent values reported for the critical DPTI/STTI ratio led us to examine this index unter maximal variations of oxygen supply and demand. 247 steady states in 15 intact dogs with patent coronary arteries, including 89 points at maximal coronary vasodilatation were analyzed. Coronary blood flow was measured directly. Oxygen supply and demand were varied by use of an intra-aortic balloon catheter, hypo-and hypervolemia, inotropic stimulation, beta adrenergic blockade, cardiac pacing, hemodilution and Persantin® (dipyridamol). Adequate myocardial oxygen supply was evaluated by precordial ECG and cardiac performance. Our studies demonstrate that DPTI bears only a poor relationship to myocardial blood flow at maximal coronary vasodilatation (r = 0.60). The result for the STTI as an estimate of myocardial oxygen demand is even poorer (r = 0.53). A number of our values were far below the reported critical DPTI/STTI ratios without occurrence of subendocardial ischemia, depressed cardiac function or myocardial edema. Therefore, great caution is necessary if the DPTI/STTI ratio is applied in the treatment of patients with heart disease.

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Pitot-Rohr-Katheter für die fortlaufende Messung der Koronar- und Nierendurchblutung im Tierexperiment

Cited by 42 publications

References 53 publications

Antagonism of Morphine With Naloxone in Dogs: Cardiovascular Effects With Special Reference to the Coronary Circulation

Antagonism of Morphine With Naloxone in Dogs: Cardiovascular Effects With Special Reference to the Coronary Circulation

Arterielle und koronarvenöse Blutgasanalysen mit einem Druckdifferenzkatheter - Arterial and Coronary Venous Blood Gas Analysis with a Pressure Difference Catheter

The DPTI/STTI Ratio as an Estimate of the Myocardial Oxygen Supply/Demand Ratio

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