Pitressin-resistant hyposthenuria in chronic renal disease

Holliday, Malcolm A.; Egan, Thomas J.; Morris, Curtis R.; Jarrah, Azmi S.; Harrah, Jean

doi:10.1016/0002-9343(67)90266-5

Cited by 39 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(c) The ability to dilute the urine, also dependent upon transport of NaCl by the ascending limb of the loop of Henle, persists long after the concentrating defect becomes overtly manifest (4). (d) The existing evidence either for or against a change in responsiveness to ADH is inconclusive (5,6). (e) Finally, no compelling data either support or contradict the thesis that a medullary washout results from increased medullary plasma flow in chronic renal insufficiency (7).…”

mentioning

confidence: 99%

See 1 more Smart Citation

A study of the intrarenal recycling of urea in the rat with chronic experimental pyelonephritis.

Gilbert¹,

Weber²,

Turchin³

et al. 1976

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The concentrating ability of the kidney was studied by clearance and micropuncture techniques and tissue slice analyses in normal rats with two intact kidneys (intact controls), normal rats with a solitary kidney (uninephrectomized controls), and uremic rats with a single pyelonephritic kidney. Urinary osmolality after water deprivation for 24 h and administration of antidiuretic hormone was 2,501+217 and 2,874±392 mosmollkg H20 in intact and uninephrectomized control rats, respectively, and 929±130 mosmol'kg H20 in pyelonephritic rats (P < 0.001 compared to each control group). Fractional water reabsorption and concentrating ability were significantly decreased in the pyelonephritic group, and, to achieve an equivalent fractional excretion of urea, a greater fractional excretion of water was required in the pyelonephritic rats than in the control rats.Whole animal glomerular filtration rate was 1.57 +0.19 ml/min and 1.39±0.18 ml/min in intact and in uninephrectomized controls, respectively, and 0.30 +0.07 ml/min in pyelonephritic rats (P < 0.001 compared to each control group). Single nephron glomerular filtration rate was 35.6±3.8 nl/min in intact control rats and was significantly increased (P < 0.05) in both uninephrectomized (88.0±10.8 nl/min) and pyelonephritic rats (71.5± 14.4 nl/min).

show abstract

mentioning

confidence: 99%

“…(a) TCH2O/GFR would be reduced and may even become negative ifisotonicity were not achieved by the time the tubular fluid reaches the ducts of Bellini, as in vasopressin-resistant hyposthenuria (5,6).…”

mentioning

confidence: 99%

A study of the intrarenal recycling of urea in the rat with chronic experimental pyelonephritis.

Gilbert¹,

Weber²,

Turchin³

et al. 1976

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Experimenits were conducted at 37°C at a transtubular osmo- Assays for adenylate cyclase on isolated cortical collecting tubules Adenylate cyclase activity in isolate(d nephron segmiienits was determined by a modification of the method of Imbert et al 2 NaCI was the solute tused to genierate the osmotic gradient. 0NaC1= 1 in the normal rabbit CCT (18).…”

Section: Perfusioni Of Cortical Collecting Tubulesmentioning

confidence: 99%

“…Among the several mechanisms proposed to explain the urinary concentrating defect of uremia is an impaired responsiveness of the kidney to vasopressin (1,2). The evidence supporting this proposed mechanism is indirect and has been derived from clearance-type studies in man.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, certain features of endstage renal disease suggest that some aspect of the uremic state per se rather than a series of separate defects, each specific for a different disease state, may account for the failure of the uremic patient to produce urine which is maximally concentrated in response to an appropriate stimulus. A large variety of renal diseases unrelated etiologically and vastly different anatomically are characterized by a urinary concentrating defect (1)(2)(3)(4)(5). Among these, disruption of the inner medullary structures (6,7) or local alterations in medtul- as an explanation for the concentrating defect.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation