Pitted erythrocytes in splenectomized subjects with congenital spherocytosis and in subjects splenectomized for other reasons

Kvinesdal, Birgit; Jensen, Mogens Krogh

doi:10.1111/j.1600-0609.1986.tb01769.x

Cited by 5 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A crucial function of the spleen is the elimination of irregularly shaped erythrocytes and thrombocytes. As a result Howell-Jolly bodies and pitted erythrocytes can be detected in the peripheral blood of spleenless patients [53][54][55]. The capacity to eliminate cellular inclusions is known as the "pitting function" of the spleen and can be regarded as indirect evidence of recovered splenic tissue.…”

Section: Discussionmentioning

confidence: 99%

Late Results of Heterotopic Autotransplantation of Splenic Tissue into the Greater Omentum

Weber

Hanisch

1998

World j. surg.

View full text Add to dashboard Cite

There is still controversy about the beneficial effects of splenic autotransplantation. As a result, replantation of the spleen has almost been abandoned for surgical treatment of splenic injuries. To learn more about the long-term effects we have analyzed eight patients 9.2 +/- 1.2 years after autotransplantation of the spleen into the greater omentum. Splenic replants could be detected by scintigraphy in seven patients (87.5%). Splenic size, measured by single-photon emission computed tomography, varied between 19.344 and 471.705 units of volume (Uov). Two patients with the smallest replants had pathologic changes of leukocytes and lymphocyte subsets in 12 of 16 measurements (75%). These changes closely resembled a spleenless state and were similar to those in the patient with no detectable splenic autograft. In contrast, five patients with large splenic replants (49.192-471.705 UoV) revealed pathologic findings in only 2 of 40 measurements (5%). Based on an extensive review of the literature and our own results, it can be concluded that splenic autotransplantation into the greater omentum is superior to splenectomy but undoubtedly less effective than in situ preservation of the spleen. Therefore splenic replantation should still be considered, particularly in pediatric surgery, when in situ preservation of the spleen is not possible by other techniques.

show abstract

Section: Discussionmentioning

confidence: 99%

Late Results of Heterotopic Autotransplantation of Splenic Tissue into the Greater Omentum

Weber

Hanisch

1998

World j. surg.

View full text Add to dashboard Cite

show abstract

“…Although the percentage of pitted erythrocytes has been determined in different haemolytic states (4, 5, [9][10][11][12], the preferential localisation of pits in favour of a certain morphological population of RBCs has not been reported previously, while the preferential localisation of red cell vacuoles to old RBCs was shown by different approaches (13, 14). Thus the preferential localisation of vacuoles to pathologically shaped erythrocytes (acanthocytes, schizocytes and even elliptocytes) appears to be new morphological sign in hyposplenism with practical implications.…”

Section: Discussionmentioning

confidence: 99%

Preferential localisation of red cell vacuoles to pathologically shaped human red blood cells

Demeter

Magyar

Varga

et al. 1989

European J of Haematology

View full text Add to dashboard Cite

The percentage of pitted erythrocytes and Howell‐Jolly bodies in peripheral blood samples of 51 individuals following posttraumatic splenectomy and 20 patients splenectomized because of various haematological diseases differed significantly from each other (p < 0.001) and from that of healthy controls (p < 0.001). The percentage of pitted erythrocytes was significantly higher in pathologically shaped red blood cells (RBCs) (acanthocytes, schizocytes, elliptocytes) than in normal discoid shaped RBCs (p < 0.001). As the number of pits per RBC showed great individual variations, a scoring system for the evaluation of pitted RBCs is proposed.

show abstract

Pocked erythrocyte counts in patients with hereditary spherocytosis before and after splenectomy

Buchanan

Holtkamp

1987

American J Hematol

View full text Add to dashboard Cite

The pocked (pitted or vacuolated) erythrocyte count has become increasingly utilized as a simple inexpensive test of splenic reticuloendothelial function. Values are less than 2.0% in normal subjects and 20 to 70% following splenectomy. Because scant and conflicting data are available about pocked erythrocyte measurements in hemolytic anemias other than the hemoglobinopathies, we performed pocked erythrocyte counts in 27 patients with hereditary spherocytosis. Prior to splenectomy patients often had elevated values (mean 4.9%). This unexpected observation suggests that hemolytic anemia may result in congestion of the red pulp and/or induced mild splenic reticuloendothelial blockade. As expected, but contrary to a previous report, pocked erythrocyte values following splenectomy were markedly increased (mean 54.9%).

show abstract

Pitted erythrocytes in splenectomized subjects with congenital spherocytosis and in subjects splenectomized for other reasons

Cited by 5 publications

References 14 publications

Late Results of Heterotopic Autotransplantation of Splenic Tissue into the Greater Omentum

Late Results of Heterotopic Autotransplantation of Splenic Tissue into the Greater Omentum

Preferential localisation of red cell vacuoles to pathologically shaped human red blood cells

Pocked erythrocyte counts in patients with hereditary spherocytosis before and after splenectomy

Contact Info

Product

Resources

About