Pituicytoma: Report of three cases with review of literature

Chakraborti, Shrijeet; Mahadevan, Anita; Govindan, Aparna; Sridhar, K; Mohan, Nilesh; Satish, I.R.; Rudrappa, Satish; Mangshetty, S.; Shankar, S K

doi:10.1016/j.prp.2012.10.006

Cited by 35 publications

(43 citation statements)

References 37 publications

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“…However, slightly elevated serum corticotropin levels were found in 1 patient, 4 and symptomatic corticotropin hypersecretion, resolved by removing a pituicytoma, has been recently described in another 24-year-old man. 3 Differently from these cases, in our patient there was a coexistence of asymptomatic pituicytoma and corticotropin-secreting adenoma. The former should be considered incidentally discovered, because the girl manifested only symptoms of CD obviously persisting after the surgical removal of the pituicytoma.…”

Section: Discussioncontrasting

confidence: 50%

“…1 To date, approximatively only 75 cases have been reported. 3,7 The most frequent symptoms of pituicytoma are visual impairment and headache. Patients can also present endocrine disturbances, such as hyperprolactinemia, hypogonadotropic hypogonadism, or hypopituitarism.…”

Section: Discussionmentioning

confidence: 99%

“…8 Uncommon in adults, it is extremely rare in childhood, with just 4 cases described so far, in children of age between 7 and 17 years. 3,5 All these children presented with visual impairment and headache, whereas short stature, as a possible sign of endocrine disturbance, was reported only in 1. 5 It is well known that pituicytoma is not a secreting tumor and that the endocrine symptoms, related to its presence, are due to the loss of pituitary function, caused by mass effect, rather than to pituitary hyperfunction.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, a total of 75 cases of pituicytoma have been reported and, among them, only 1 occurred in association with Cushing's disease (CD) 2 and 2 with not clearly defined hypercortisolism. 3,4 Only 4 pediatric patients 5 with pituicytoma have been described so far. We report the first case of a 7-year-old girl with pituicytoma in association with corticotropin secreting adenoma.…”

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Pituicytoma and Cushing’s Disease in a 7-Year-Old Girl: A Mere Coincidence?

Cambiaso¹,

Amodio

Procaccini³

et al. 2015

Pediatrics

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Pituicytoma is a tumor extremely rare in childhood, with only 4 cases reported in literature. It is thought to arise from the specialized glial elements called "pituicytes." The association of pituicytoma and Cushing's disease (CD) has been described only once so far, in an adult patient. A 7-year-old girl was referred for clinical signs of hypercortisolism, and a diagnosis of CD was made. MRI revealed 2 pathologic areas in the pituitary gland. The patient underwent surgery, with microscopic transsphenoidal approach, and a well-circumscribed area of pathologic tissue was identified and removed. Surprisingly, histologic and immunohistochemical study provided unequivocal evidence of pituicytoma. No pituitary adenoma could be identified. For persistent hypercortisolism, the patient necessitated transsphenoidal endoscopic reintervention and 2 other lesions were removed. By immunohistological examination, these lesions were confirmed to be corticotropin-secreting adenoma. Unfortunately, there was no postoperative decrease in corticotropin and cortisol levels, and the patient underwent bilateral laparoscopic adrenalectomy. Considering that we report a second case of association of pituicytoma and corticotropin-secreting adenoma, that CD is infrequent, and pituicytoma is extremely rare in childhood, the coexistence of these 2 tumors should not be considered a mere coincidence. To date, there is no conclusive evidence about the origin of these different subtypes of pituitary tumors. This case supports the hypothesis that these tumors share a common progenitor cell, which could be the folliculostellate cell.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Pituicytoma and Cushing’s Disease in a 7-Year-Old Girl: A Mere Coincidence?

Cambiaso¹,

Amodio

Procaccini³

et al. 2015

Pediatrics

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“…The most common symptoms of pituicytoma were vision and visual field disorders (44 cases, 56.4%), headaches (34 cases, 43.6%), hypopituitarism (17 cases, 21.8%), hyposexuality (16 cases, 20.5%), sexual dysfunction (7 cases, 9.0%), menstrual disorder (7 cases, 9.0%), dizziness (6 cases, 7.7%), diabetes insipidus (3 cases, 3.8%) (10-12), epilepsy (3 cases, 3.8%) (13)(14)(15), gynecomastia (3 cases, 3.8%) (10,16,17) and spontaneous tumor hemorrhage (1 case, 1.3%) (18). There were also sporadic cases that presented with nausea (6), vomiting (9) or edema (9). In one case the pituicytoma was incidentally revealed at autopsy (19).…”

Section: Discussionmentioning

confidence: 99%

Pituicytoma: A report of three cases and literature review

Yang

Liu

et al. 2016

Oncology Letters

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Abstract. Pituicytoma is a rare tumor of the sellar and suprasellar regions, arising from the pituicytes, which are specialized glial cells in the neurohypophysis and infundibulum. Due to its rarity, ambiguity persists over the diagnosis, management and prognosis of pituicytoma. The current study presents a case series of three patients, each with a histopathological diagnosis of pituicytoma. A summary of the clinical manifestations, radiological characteristics, histopathological features, treatment strategies and prognoses are presented. In addition, 78 cases of pituicytoma, identified in a search of the published literature in Pubmed, are profiled. Pituicytoma typically presents with dysfunction of the optic nerve and pituitary. The radiological characteristics are nonspecific; diagnosis is typically made on the basis of histopathological results. The tumor is slow growing and benign and is amenable to surgical treatment by gross total resection; subsequent tumor recurrence is rare. A definitive assessment of prognosis requires an extended follow-up in a larger cohort.

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