Pituitary Adenoma Associated with Intraventricular Meningioma: Case Report

Abstract

Although rare, the association of intracranial meningiomas and pituitary adenomas has been reported. Intraventricular meningiomas are unusual, and meningiomas located in the fourth ventricle are even more so. We report a patient who harbored a prolactin-secreting pituitary adenoma and a fourth ventricle meningioma who was treated with surgical resection of the latter and medical treatment for the former. To our knowledge, this is the first report of such an unusual association.

Coexisting intracranial tumors with pituitary adenomas: Genetic association or coincidence?

“…Meningiomas form 15−25% of all intracranial neoplasms and have an annual incidence of 6/ 100,000. [1,2] Pituitary adenomas (PA) are reported to co-occur with various grades of glial neoplasms, gliomatosis cerebri, schwannomas, medulloblastomas, and meningiomas. [1][2][3][4][5][6][7] The coexisting pituitary tumor varied from clinically silent lesions to functioning adenomas like prolactinomas and growth hormone (GH)-and thyrotropin (TSH)-secreting tumors.…”

“…[1,2] Pituitary adenomas (PA) are reported to co-occur with various grades of glial neoplasms, gliomatosis cerebri, schwannomas, medulloblastomas, and meningiomas. [1][2][3][4][5][6][7] The coexisting pituitary tumor varied from clinically silent lesions to functioning adenomas like prolactinomas and growth hormone (GH)-and thyrotropin (TSH)-secreting tumors. [1,2,[4][5][6]8] We evaluated the possible tumor induction factors and previously described genetic abnormalities which could link the two unrelated pathologies.…”

Coexisting Pituitary Adenoma and Suprasellar Meningioma: A Coincidence or Causation Effect? Report of Two Cases and Review of Literature

“…The pathogenesis of coexistence of different lesions in the sella and suprasellar region has not been elucidated. Concurrent adjacent double tumors in other locations of central nervous system (CNS) are even more implying the effect of unknown oncogenic factors (7). In this communication, we do not intend to report collision 'intrasellar' pathologies (12)(13)(14) but two cases of concomitant brain tumors (CCBT) are reported.…”

“…The coexistence of PA and another type of brain tumor is a very rare clinical scenario (4,5). The type of PAs reported in such series varied from, clinically silent lesions "non-functional" to functioning adenomas such as prolactinomas and growth hormone (GH)-and thyrotropin (TSH)-secreting tumors (1,4,(6)(7)(8)(9). In cases of PA concurrent with meningioma, GH-secreting adenoma is the most predominant (9)(10)(11).…”

Prolactinoma associated with an ependymoma in the fourth ventricle: A case report and review of the literature

“…However, numerous reports have described incidences of pituitary adenoma concomitant with other types of cranial cavity tumor, such as meningioma (2)(3)(4), medulloblastoma (5), neurinoma (6), craniopharyngioma (7), astrocytoma (8) and glioma (9). While the etiology and underlying mechanisms for the development of these tumors remain unclear, it has been proposed that genomic and endocrine disorders, as well as radiation therapy and embryogenesis, may be important factors (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The majority of pituitary adenomas concomitant with other cranial tumors are diagnosed by MRI or CT, current treatment strategies include the simultaneous or staged resection (12).…”