Pituitary adenoma in adolescents: a biologically more aggressive disease?

Fisher, Barbara; Gaspar, L.; Stitt, L.; Noone, B E

doi:10.1148/radiology.192.3.8058963

Cited by 22 publications

(8 citation statements)

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“…These observations were confirmed by Fisher et al, who demonstrated a more aggressive course of the disease and rapid expansion of pituitary adenomas in patients under 20 years of age [17]. Identical conclusions were also reported by other authors, who observed a higher risk of Nelson's syndrome and a more aggressive course of the disease in children [18,19].…”

Section: Prace Oryginalnesupporting

confidence: 72%

Wyniki leczenia neurochirurgicznego gruczolaków kortykotropowych przysadki w zespole Nelsona — pułapki terapeutyczne

Zieliński

Witek

Maksymowicz

2015

Endokrynologia Polska

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Introduction: Nelson's syndrome (NS) is a rare clinical syndrome caused by an enlarging, aggressive corticotroph pituitary adenoma that can occur following bilateral adrenalectomy performed in the treatment of refractory Cushing's disease (CD). Such tumours respond poorly to currently available therapeutic options, which include surgery, radiotherapy, pharmacotherapy, and chemotherapy. They are a challenging problem in neurosurgical practice. The aim of this work was to evaluate the early and long-term results of microsurgery in a single surgeon's series of patients with NS.

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Section: Prace Oryginalnesupporting

confidence: 72%

Wyniki leczenia neurochirurgicznego gruczolaków kortykotropowych przysadki w zespole Nelsona — pułapki terapeutyczne

Zieliński

Witek

Maksymowicz

2015

Endokrynologia Polska

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“…In spite of the feasibility of gross total resection, recurrence rate is higher in pediatric populations [25,26,27]. We have 3 cases of subtotal resection in our series.…”

Section: Discussionmentioning

confidence: 97%

Transnasal Transsphenoidal Surgical Method in Pediatric Pituitary Adenomas

Taşkapılıoğlu¹,

Yılmazlar²,

Eren

et al. 2015

Pediatr Neurosurg

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Aim: To evaluate the clinical outcome in a 13-year consecutive series of children operated for pituitary adenomas with transnasal transsphenoidal surgery. Methods: All patients <18 years who were operated on at our center by transsphenoidal surgery for pediatric pituitary adenomas were included in the study. Clinical features, hormonal profile, radiology, surgical approach, results and complications were analyzed. Results: Eighteen patients (90%) had functional pituitary adenomas and 2 (10%) patients had nonfunctional pituitary adenoma. The most common type was prolactin-secreting adenoma (n = 12), followed by corticotropinoma (n = 4), growth hormone-secreting adenoma (n = 2), and nonfunctioning adenoma (n = 2). Prolactin-secreting adenomas in children occurred more commonly with suprasellar expansion than did other adenomas. Conclusion: Transsphenoidal surgery was effective for decompression of suprasellar extension and relieved the chiasmal compression immediately. Prolactin-secreting tumors required postoperative medical therapy for persistently elevated prolactin levels.

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“…Currently, the biological basis of pituitary adenomas presenting during childhood and adolescence is unclear. A study of 178 patients referred to a radiation center showed that adolescents with pituitary adenomas had larger tumor size and shorter time to tumor progression or recurrence than those of older adults 12 . In a report of 161 patients with Cushing disease from Massachusetts General Hospital (mostly adults) who were operated by the same neurosurgery team as in our study 13 , the recurrence rate was only 7%, suggesting that the high recurrence rate of Cushing disease in our pediatric series might reflect more aggressive biology of these tumors in children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Pituitary Adenomas in Children and Adolescents

Katavetin

Cheunsuchon²,

Swearingen

et al. 2010

Journal of Pediatric Endocrinology and Metabolism

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Clinical manifestations and outcomes of pituitary adenomas in children are not clearly defined. We retrospectively reviewed cases of pituitary adenomas in children 0-18 years treated at MassGeneral Hospital for Children over 15 years. Thirty-five patients were identified. Age at presentation was 7-18 years. Seventeen had prolactinomas, 3 had somatotropinomas, and 15 had Cushing disease. Thirteen prolactinoma patients were female and most commonly presented with oligomenorrhea (10/13) and galactorrhea (7/13). Nine were successfully treated medically. Two somatotropinoma patients presented with visual disturbances; the third was an incidental finding. Two were cured by transsphenoidal surgery (TSS). Thirteen Cushing disease patients were initially cured by TSS; six recurred after 3-6 years. Patients with or without recurrence did not differ for age, tumor-size and hormone levels. The high recurrence rate of Cushing disease in our series (46%) compared with adults treated surgically at this institution (7%) emphasizes the need for long-term follow-up.

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Pituitary adenoma in adolescents: a biologically more aggressive disease?

Abstract: Adolescents with pituitary adenoma who do not receive postoperative radiation should be followed up closely and undergo imaging at more frequent intervals than do adult patients.

Cited by 22 publications

References 0 publications

Wyniki leczenia neurochirurgicznego gruczolaków kortykotropowych przysadki w zespole Nelsona — pułapki terapeutyczne

Wyniki leczenia neurochirurgicznego gruczolaków kortykotropowych przysadki w zespole Nelsona — pułapki terapeutyczne

Transnasal Transsphenoidal Surgical Method in Pediatric Pituitary Adenomas

Pituitary Adenomas in Children and Adolescents

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